Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D

Walker, Gillian E.; Follenzi, Antonia; Bruscaggin, Valentina; Manfredi, Marcello; Bellone, Simonetta; Marengo, Emílio; Maiuri, Luigi; Prodam, Flavia; Bona, Gianni

doi:10.1016/j.jsbmb.2018.04.009

Cited by 6 publications

(4 citation statements)

References 79 publications

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“…In humans, plasma fetuin B levels are increased in obese individuals with hepatic steatosis (36) and T2D, and associated positively with intrahepatic triglyceride and insulin resistance (36, 58). However, the mechanism underlying its role in these pathogeneses remains unclear.…”

Section: Fetuin Bmentioning

confidence: 99%

Cytokines and Abnormal Glucose and Lipid Metabolism

et al. 2019

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Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role linking to the induction of metabolic dysfunction. The mechanisms involved are not fully understood, but are associated with lipid accumulation in organs and tissues, especially in the adipose and liver tissue, changes in energy metabolism, and inflammatory signals derived from various cell types, including immune cells. In this review, we describe the roles of certain cytokines in the regulation of metabolism and inter-organ signaling in regard to the pathophysiological aspects. Given the disease-related changes in circulating levels of relevant cytokines, these factors may serve as biomarkers for the early detection of metabolic disorders. Moreover, based on preclinical studies, certain cytokines that can induce improvements in glucose and lipid metabolism and immune response may emerge as novel targets of broader and more efficacious treatments and prevention of metabolic disease.

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Section: Fetuin Bmentioning

confidence: 99%

Cytokines and Abnormal Glucose and Lipid Metabolism

et al. 2019

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“…Recently, several epidemiological and experimental studies have indicated that VD supplementation is effective in reducing body weight, body-mass index, and fat mass and is associated with decreased levels of low-density lipoprotein cholesterol (32,33). In this study, we investigated whether the effects of maternal VD status during pregnancy and lactation had a long lasting adverse effect on the progress of obesity in the male offspring.…”

Section: Discussionmentioning

confidence: 99%

Maternal vitamin D deficiency increases the risk of obesity in male mice offspring by affecting the immune response

Liu³

et al. 2020

Preprint

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Recently, many epidemiological and animal studies have indicated 29 that obesity have their origin in the early stages of life including the inappropriate 30 balance of some nutrients, the objective of this study is to determine the risk of obesity 31 in male mice offspring as a consequence of maternal VD deficiency-mediated 32 disordering of the immune response. Four-week-old C57BL/6J female mice were fed 33 VD-deficient or normal reproductive diets during pregnancy and lactation. Their male 34 offspring were weighted and euthanized after being fed control and high-fat diets (HFD) 35 for 16 weeks starting at the weaning. The serum was collected for biochemical analyses. 36 Epididymal (eWAT) and inguinal (iWAT) white adipose tissues were excised for 37 histological examination, immunohistochemistry, gene expressions of inflammatory 38 factors, and for determining the proportions of immune cells by flow cytometry. 39Insufficient maternal VD intake exacerbated the development of obesity both in 40 non-obese and obese male offspring as evidenced by larger adipose cells and 41 abnormal glucose and lipid metabolisms. Also, the expression of proinflammatory 42 cytokine genes was increased and that of anti-inflammatory cytokines was decreased 43 in maternal VD-deficient groups in the eWAT and/or iWAT. This was accompanied by 44 higher levels of TNF-α or/and INF-γ, and lower levels of IL-4 and IL-10. Insufficient 45 maternal VD intake was also observed to induce a shift in the profiles of immune cells 46 in the eWAT and/or iWAT, resulting in increased percentages of M1 macrophage, 47 ATDCs, and CD4 + and CD8 + T cells, but caused a significant decrease in the 48 percentage of M2 macrophages, both in non-obese and obese male offspring. All these 49 3 changes in the immune cell profile were more obvious in the eWAT than in the iWAT. 50These results indicated that insufficient maternal VD intake promoted the development 51 of obesity in male offspring by modulating the immune cell populations and causing a 52 polarization in the adipose depots. 53Importance Evidence in this study has indicated that insufficient maternal VD 54 intake promotes the development of obesity in the male offspring by modulating the 55 recruitment of immune cell populations and their polarization as well as the 56 expression and secretion of proinflammatory adipokines in the adipose depots in a 57 weight-independent manner, which is more obvious in eWAT than that in the iWAT. 58 Introduction 60 The prevalence of overweight and obesity has reached epidemic proportions 61 throughout the world, and is associated with increased morbidity and mortality, 62 contributing to the burden of chronic diseases (1-3). However, the mechanisms 63 underlying obesity remain unclear. There is, therefore, an urgent need for effective 64 intervention strategies. During the past decade, the state of chronic low-grade systemic 65 inflammation caused by inflation of adipose tissue macrophages (ATMs), followed by 66 increased production of pro-inflammatory cytokine...

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“…In a 2DGE-based study, vitamin D deficient children are reported to have diminished serum abundances of adiponectin (ADIPOQ) [189]. In a separate 2DGE-based study, the same group reports fetuin-b (FETUB) to be elevated in the plasma of obese vitamin D deficient children compared with their vitamin D sufficient counterparts [190]. However the authors do not directly identify FETUB and rely on comparison of their findings to those of another study [191].…”

Section: Vitamin Dmentioning

confidence: 99%

Systemic vitamin intake impacting tissue proteomes

Jeong

Vacanti

2020

Nutr Metab (Lond)

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The kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze them. These enzymes are controlled via a myriad of mechanisms including inhibition/activation by metabolites, compartmentalization, thermodynamics, and nutrient sensing-based transcriptional or post-translational regulation; all of which are influenced as a network by the activities of metabolic enzymes and have downstream potential to exert direct or indirect control over protein abundances. Considering many of these enzymes are active only when one or more vitamin cofactors are present; the availability of vitamin cofactors likely yields a systems-influence over tissue proteomes. Furthermore, vitamins may influence protein abundances as nuclear receptor agonists, antioxidants, substrates for post-translational modifications, molecular signal transducers, and regulators of electrolyte homeostasis. Herein, studies of vitamin intake are explored for their contribution to unraveling vitamin influence over protein expression. As a body of work, these studies establish vitamin intake as a regulator of protein abundance; with the most powerful demonstrations reporting regulation of proteins directly related to the vitamin of interest. However, as a whole, the field has not kept pace with advances in proteomic platforms and analytical methodologies, and has not moved to validate mechanisms of regulation or potential for clinical application.

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Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D

Abstract: Graphical Abstract

Cited by 6 publications

References 79 publications

Cytokines and Abnormal Glucose and Lipid Metabolism

Cytokines and Abnormal Glucose and Lipid Metabolism

Maternal vitamin D deficiency increases the risk of obesity in male mice offspring by affecting the immune response

Systemic vitamin intake impacting tissue proteomes

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