Fetomortalidade Tardia: Estudo Coorte de dez anos

Robalo, Raquel; Pedroso, Célia; Amaral, Njila; Soares, Carla

doi:10.20344/amp.4011

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…The impact of placental abnormalities on the aetiology of stillbirth is indisputable, as supported by observations of placental pathology in several clinical conditions linked to increased stillbirth rates, including FGR, pre-eclampsia, and placental abruption [13]. Interestingly, stillbirth demonstrates a strong association with FGR, exhibiting a considerable overlap in risk factors and potential causes between stillbirth and FGR [14,15]. Identified causes of stillbirth encompass conditions affecting the mother and/or the foetus, such as maternal hypertension, foetal-maternal haemorrhage, congenital anomalies, infections, and umbilical cord abnormalities [14,16].…”

Section: Of 17mentioning

confidence: 91%

“…Interestingly, stillbirth demonstrates a strong association with FGR, exhibiting a considerable overlap in risk factors and potential causes between stillbirth and FGR [14,15]. Identified causes of stillbirth encompass conditions affecting the mother and/or the foetus, such as maternal hypertension, foetal-maternal haemorrhage, congenital anomalies, infections, and umbilical cord abnormalities [14,16].…”

Section: Of 17mentioning

confidence: 99%

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Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths

Vasconcelos,

Moustakas,

Branco

et al. 2024

IJMS

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The trophoblast cells are responsible for the transfer of nutrients between the mother and the foetus and play a major role in placental endocrine function by producing and releasing large amounts of hormones and growth factors. Syncytiotrophoblast cells (STB), formed by the fusion of mononuclear cytotrophoblasts (CTB), constitute the interface between the foetus and the mother and are essential for all of these functions. We performed transcriptome analysis of human placental samples from two control groups—live births (LB), and stillbirths (SB) with a clinically recognised cause—and from our study group, idiopathic stillbirths (iSB). We identified 1172 DEGs in iSB, when comparing with the LB group; however, when we compared iSB with the SB group, only 15 and 12 genes were down- and upregulated in iSB, respectively. An assessment of these DEGs identified 15 commonly downregulated genes in iSB. Among these, several syncytiotrophoblast markers, like genes from the PSG and CSH families, as well as ALPP, KISS1, and CRH, were significantly downregulated in placental samples from iSB. The transcriptome analysis revealed underlying differences at a molecular level involving the syncytiotrophoblast. This suggests that defects in the syncytial layer may underlie unexplained stillbirths, therefore offering insights to improve clinical obstetrics practice.

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Section: Of 17mentioning

confidence: 91%

Section: Of 17mentioning

confidence: 99%

Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths

Vasconcelos,

Moustakas,

Branco

et al. 2024

IJMS

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Investigation of stillbirths in Brazil: A systematic scoping review of the causes and related reporting processes in the past decade

Souza

Brasileiro

Ong

et al. 2022

Intl J Gynecology & Obste

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Background Recognizing the causes of stillbirths and their associated conditions is essential to reduce its occurrence. Objective To describe information on stillbirths in Brazil during the past decade. Search strategy A literature search was performed from January 2010 to December 2020. Selection criteria Original observational studies and clinical trials. Data collection and analysis Data were manually extracted to a spreadsheet and descriptive analysis was performed. Results A total of 55 studies were included; 40 studies (72.2%) used the official data stored by national public health systems. Most articles aimed to estimate the rate and trends of stillbirth (60%) or their causes (55.4%). Among the 16 articles addressing the causes of death, 10 (62.5%) used the International Classification of Diseases; most of the articles only specified the main cause of death. Intrauterine hypoxia was the main cause reported (ranging from 14.3% to 54.9%). Conclusion Having a national system based on compulsory notification of stillbirths may not be sufficient to provide quality information on occurrence and, especially, causes of death. Further improvements of the attribution and registration of causes of deaths and the implementation of educational actions for improving reporting systems are advisable. Finally, expanding the investigation of contributing factors associated with stillbirths would create an opportunity for further development of prevention strategies in low‐ and middle‐income countries such as Brazil.

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Factors associated with late fetal mortality

Hidalgo-Lópezosa

Cobo-Cuenca

Carmona‐Torres

et al. 2018

Arch Gynecol Obstet

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The rate of late fetal mortality in Spain has not decreased and has remained at the same level as in 2010. This result is related to prematurity, low birth weight, macrosomia and sociodemographic factors, such as low maternal preparation, mothers of African origin, age ≥ 35 years and mothers who are single. It is necessary to improve the quality and accessibility of prenatal care and the early detection of risk factors.

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Fetomortalidade Tardia: Estudo Coorte de dez anos

Cited by 7 publications

References 10 publications

Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths

Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths

Investigation of stillbirths in Brazil: A systematic scoping review of the causes and related reporting processes in the past decade

Factors associated with late fetal mortality

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