Feto-maternal outcomes of pregnancy complicated by ovarian malignant germ cell tumor: a systematic review of literature

Kodama, Michiko; Grubbs, Brendan H.; Blake, Erin A.; Cahoon, Sigita S.; Murakami, Ryusuke; Kimura, Tadashi; Matsuo, Koji

doi:10.1016/j.ejogrb.2014.07.047

Cited by 39 publications

(39 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…51 Additionally, in the aforementioned study of treatment of malignant germ cell tumors, half of patients underwent chemotherapy, 76.9% of which was cisplatin with bleomycin. 52 Recurrence occurred in 6.9%, and overall five-year survival was 80.1%. Intrauterine growth restriction occurred in 22.8% of cases, without a significantly increased risk associated with intrauterine chemotherapy exposure.…”

Section: Ovarian Masses and Cancer In Pregnancymentioning

confidence: 97%

See 1 more Smart Citation

Gynecologic Malignancies in Pregnancy: Balancing Fetal Risks With Oncologic Safety

Cordeiro¹,

Gemignani²

2017

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

Importance Cancer occurs in 0.05 to 0.1% of all pregnancies.1,2 Despite literature reporting good oncologic and fetal outcomes in women treated for cancer during pregnancy, as many as 44% of gynecologists would offer termination, and 37% would not administer chemotherapy or radiotherapy in pregnancy.1 Objectives To summarize current recommendations for the treatment of cervical and ovarian cancers in pregnancy. To review updates on existing knowledge regarding the safety of surgical and chemotherapeutic treatments in pregnancy, including both oncologic and fetal outcomes. Evidence Acquisition A detailed literature review was performed on PubMed. Results The treatment of gynecologic malignancies during pregnancy mirrors that outside of pregnancy, with a balance between maternal versus fetal health. Fertility-sparing surgery can be offered to stage IA2 and low-risk IB1 cervical, stage I epithelial ovarian, germ cell ovarian or sex-cord stromal ovarian tumors.1,9 Delayed treatment can be offered for stage IB1 cervical cancer.1,3 Neoadjuvant and/or adjuvant chemotherapy can be given for advanced gynecologic cancers with good disease-free survival without significant adverse neonatal outcomes.29–31,41,47,48 Conclusions A multidisciplinary approach and improved education of providers regarding the surgical and chemotherapeutic treatments in pregnancy is needed in order to fully inform patients regarding treatment options. Further research is needed to determine the safety of diagnostic and therapeutic procedures used in the non-pregnant woman in women who are pregnant. Relevance This article reviews and supports treatment of gynecologic cancer during pregnancy, calls for additional study and long-term follow-up, and justifies improved education of patients and providers regarding treatment options.

show abstract

Section: Ovarian Masses and Cancer In Pregnancymentioning

confidence: 97%

“…Intrauterine growth restriction occurred in 22.8% of cases, without a significantly increased risk associated with intrauterine chemotherapy exposure. 52 …”

Section: Ovarian Masses and Cancer In Pregnancymentioning

confidence: 99%

Gynecologic Malignancies in Pregnancy: Balancing Fetal Risks With Oncologic Safety

Cordeiro¹,

Gemignani²

2017

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

show abstract

“…The majority of tumors present as Stage I, with a mean age of 25.8 years and 31.6 years in germ cell tumors and invasive epithelial cancers, and mean size of 18 and 12 cm, respectively. 31,32 Transvaginal and abdominal ultrasound have high sensitivity and specificity in the diagnosis of ovarian masses. However, MRI has the best diagnostic accuracy in the diagnosis of ovarian malignancy in pregnancy.…”

Section: Ovarian Cancermentioning

confidence: 99%

Cancer in pregnancy

Botha

Rajaram

Karunaratne

2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

The incidence of cancer in pregnancy is increasing. The most frequent malignancies include breast and cervical cancers. Diagnosis may be complicated by late presentation. Imaging during pregnancy should consider risks to the fetus. Diagnostic work‐up, including tumor markers, can be influenced by the physiology of pregnancy. Treatment of cancer can often be safely administered with good maternal and fetal outcomes. Chemotherapy, radiotherapy, and surgery must be adapted to the pregnancy state. Counselling and emotional support are an essential part of management.

show abstract

“…The results of a recent study indicated that advanced-stage GCT-complicated pregnancies were an independent prognosticator of decreased maternal survival (12). The timing of oncological intervention and delivery both significantly impacted on the outcomes both of foetal and maternal survival.…”

Section: Gctsmentioning

confidence: 99%