Cancer in pregnancy

Botha, Matthys H.; Rajaram, Shalini; Karunaratne, Kanishka

doi:10.1002/ijgo.12621

Cited by 57 publications

(51 citation statements)

References 43 publications

(97 reference statements)

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“…All women who were delivered before 34 weeks were given Betamethasone to improve lung maturity in the neonate. 3 IA -Iodine ablation, 4 TOP -Termination of pregnancy, 5 LSCS -Lower segment caesarean section, 6 CT -Chemotherapy, 7 RT -Radiotherapy, 8 CNS -Central nervous system, 9 GIT -Gastrointestinal tract, 10 LTF -Lost to follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…These chemotherapeutic agents are recommended to be used in the second and third trimesters and Taxane group drugs are better avoided but could be given depending on the disease status after the first trimester. 3 In this study majority of women with breast cancer were allowed to continue pregnancy as it is seen that treatment delays due to pregnancy did not have an adverse effect on the outcome of breast cancer and studies have not shown that terminating a pregnancy improves a woman's prognosis. 7 Central nervous system malignancies during pregnancy is again rare.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy outcomes in non-gynecological and non-hematological cancers: a retrospective cohort

Kumari

Yenuberi

Rathore

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Of all the cancers in women, about 10% manifest in the reproductive age group. These can be broadly classified as gynaecological cancers and non-gynaecological cancers; Among the non-gynaecological cancers besides haematological cancer, breast, thyroid, colon, bone and CNS are seen rarely. Clinical acumen in diagnosis and management of these rare cancers that appear during pregnancy or before pregnancy are difficult due to insufficient guidelines and rarity of the conditions.Methods: A retrospective analysis of rare cancers during a period of 10 years in this hospital was performed. Data concerning the gestational age at delivery, birth weight, mode of delivery and complications and the management of the cancers during the pregnancy were collected.Results: Among the 41 women with these rare non-gynecological, non-hematological cancers, 13 pregnancies were in women with prior history of cancers and 28 pregnancies were with current history of cancer. Majority of these cases with prior history were thyroid cancers who had uneventful pregnancies and delivered normally. Among pregnancies with current history of cancer, breast, CNS, GIT, and head and neck were the cancers with 5-6 cancers in each category. About 50% of these cancers were delivered early between 31-35 weeks to facilitate optimal treatment. Cancers with guarded prognosis diagnosed before 20 weeks had a termination of pregnancy.Conclusions: Cancers during pregnancies are rare and their care must be individualized.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in non-gynecological and non-hematological cancers: a retrospective cohort

Kumari

Yenuberi

Rathore

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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“…18 Preventive cervical cerclage can be used to prevent premature delivery and surgical bleeding. 19 The treatment of stage I A2-I B1 cervical cancer before 22-25 weeks of gestation 1. For stage I A2-I B1 cervical cancer, when lymph node not involved and tumor diameter less than 2 cm, if was noted that only less than 1% of the patients had parametrial extension.…”

Section: Treatment Of Stage I A1 Cervical Cancer 22-25 Weeks Of Pregnmentioning

confidence: 99%

“…A retrospective study found that women with cervical conization (>1 cm) had a higher risk of premature birth and low birth weight than women who did not undergo cervical conization . Preventive cervical cerclage can be used to prevent premature delivery and surgical bleeding …”

Section: Introductionmentioning

confidence: 99%

“… For stage I A2‐I B1 cervical cancer, when lymph node not involved and tumor diameter less than 2 cm, if was noted that only less than 1% of the patients had parametrial extension. Therefore, conization of cervix or simple cervical resection can be carried out; or the pregnancy can be allowed to progress and treatment postponed until fetal maturity. Simple cervical resection is a less complex operation, referring to the removal of tumor 1 cm above the tumor boundary .…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and treatment of cervical cancer in pregnant women

Beharee

Shi

et al. 2019

Cancer Medicine

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In recent years, the incidence of gynecological malignant tumors during pregnancy has increased, mainly due to the increased number of old age pregnancy. The most common gynecological malignant tumors in pregnancy are cervical cancer, accounting for 71.6%, followed by ovarian malignant tumors, accounting for 7.0%. The incidence of cervical cancer in pregnancy is itself not very high, and the symptoms are easily confused with other diseases in pregnancy. During pregnancy, gynecological examination is limited, and therefore, the rate of misdiagnosis is higher. The treatment of cervical cancer during pregnancy is related to many factors, such as tumor size, pathological type, period of gestation, lymph node involvement, and patients' willingness to maintain pregnancy. As a reason of these factors, it is difficult to determine the optimal treatment. This article reviews the research progress on the diagnosis and treatment principles of cervical cancer in pregnancy, in order to strike a balance between effective treatment of tumors and protection of fetal health, and avoid delays in treatment and preterm delivery.

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Development and validation of the low‐cost pregnant female physical phantom for fetal dosimetry in MV photon radiotherapy

Kopačin,

Brkić,

Ivković

et al. 2023

J Applied Clin Med Phys

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BackgroundMonte Carlo (MC) simulations or measurements in anthropomorphic phantoms are recommended for estimating fetal dose in pregnant patients in radiotherapy. Among the many existing phantoms, there is no commercially available physical phantom representing the entire pregnant woman.PurposeIn this study, the development of a low‐cost, physical pregnant female phantom was demonstrated using commercially available materials. This phantom is based on the previously published computational phantom.MethodsThree tissue substitution materials (soft tissue, lung and bone tissue substitution) were developed. To verify Tena's substitution tissue materials, their radiation properties were assessed and compared to ICRP and ICRU materials using MC simulations in MV radiotherapy beams. Validation of the physical phantom was performed by comparing fetal doses obtained by measurements in the phantom with fetal doses obtained by MC simulations in computational phantom, during an MV photon breast radiotherapy treatment.ResultsMaterials used for building Tena phantom are matched to ICRU materials using physical density, radiation absorption properties and effective atomic number. MC simulations showed that percentage depth doses of Tena and ICRU material comply within 5% for soft and lung tissue, up to 25 cm depth. In the bone tissue, the discrepancy is higher, but again within 5% up to the depth of 5 cm. When the phantom was used for fetal dose measurements in MV photon breast radiotherapy, measured fetal doses complied with fetal doses calculated using MC simulation within 15%.ConclusionsPhysical anthropomorphic phantom of pregnant patient can be manufactured using commercial materials and with low expenses. The files needed for 3D printing are now freely available. This enables further studies and comparison of numerical and physical experiments in diagnostic radiology or radiotherapy.

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Cancer in pregnancy

Cited by 57 publications

References 43 publications

Pregnancy outcomes in non-gynecological and non-hematological cancers: a retrospective cohort

Pregnancy outcomes in non-gynecological and non-hematological cancers: a retrospective cohort

Diagnosis and treatment of cervical cancer in pregnant women

Development and validation of the low‐cost pregnant female physical phantom for fetal dosimetry in MV photon radiotherapy

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