Feto-Maternal Interaction of Antibody and Antigen Transfer, Immunity and Allergy Development

Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function

“…It has been shown recently that peripheral blood dendritic cell TLR-9 suppression can be induced by IgE activation. 22 Whether 23 or not 24 maternal IgE can cross the placenta has been debated, but IgE produced in the neonate, through cross reactivity with maternally derived allergens, 24,25 has been demonstrated and thus could explain the observed decreased TLR-9 expression in our high-risk infants. However, this might be unlikely because there were no differences between circulating total CB IgE levels in the 2 groups (Table I).…”

Role of maternally derived immunity in fish

“…Maternal immunity transmission is defined as the transfer of immune factors by an immunocompetent female to an immunologically naive neonate transplacentally or through colostrum, milk or yolk [1] and the detailed mechanism of immunity transmission and utilization have been established in different vertebrates [6][7][8][9]87,88]. The phenomenon of maternal immunity transfer is not restricted to vertebrates only.…”

Serum IgG Responses and Seroconversion Patterns to Cryptosporidium gp15 among Children in a Birth Cohort in South India

“…Although studies examining pairs of maternal and cord blood samples have found good correlation in the antibody levels between them (14,50,60), the transfer of antibodies could be influenced by factors like prematurity and gestational age (31). Data on cord blood samples might provide more robust estimates.…”