Fetal valproate syndrome as an experimental model of autism

Малышев, А. В.; Abbasova, Kenul; Averina, Olga A.; Solovieva, L. N.; Gedzun, V.; Gulyaev, Mikhail V.; Дубынин, В. А.

doi:10.3103/s0096392515030074

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…However, changes have also been found in the brains of female autistic patients [17]. Animals prenatally exposed to VPA show similar effects to humans with autism [18]. Some of these changes are: hyperconnectivity and hyperplasticity in the frontal cortex [19], a decrease in the number and size of the amygdala neurons [20] [21], a reduction in the number of Purkinje cells in cerebellum [22] [23], an increase in the volume of caudate one [24], and a series of changes in the hippocampus [25] [26] such as reduction in the size of CA4 cells and the dendritic branching of the CA1 and CA4 cells [27].…”

Section: Introductionmentioning

confidence: 78%

Differential Effects of Valproic Acid on Immobility Responses and Locomotor Activity in Female and Male Rats

Morales-Dionisio¹,

Cruz²,

Franco-Colín³

et al. 2017

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Valproic acid (VPA) is used in the treatment of epilepsy and behavioral disorders. However, the exposure to VPA during pregnancy increases the risk of having offspring with autism spectrum disorder (ASD). Reports indicate that men are more likely to suffer ASD than women who were exposed to VPA prenatally. Few studies have related the sex differences and behavioral changes in the ASD rat model. Our aim was to determinate whether male and female Wistar rats whose mothers were exposed to either VPA (600 mg/kg; animal model for ASD) or saline (0.9%) i.p. at 12.5 day of gestation, have different effects on immobility induce by clamping (IC), dorsal immobility (DI), catalepsy, locomotor activity, stereotypes, and analgesia (tail flick). For this purpose, we made four groups (n = 8). Group: A) saline male rats, B) saline female rats, C) VPA male rats and D) VPA female rats. At 35 (prepubertal age), 56 (postpubertal age) and 180 days, we tested the behaviors previously mentioned. Finding that VPA has the same effect on IC, catalepsy, and analgesia in male and female rats, the time of these tests was increased. However, VPA only has an effect on DI in males but not in female rats. On the contrary, there is hyperactivity and an increase of stereotypes in female but not in male rats. Thereby, VPA has an effect on the three immobility responses tested (IC, DI and catalepsy), locomotor activity and analgesia but in a differential way on DI, stereotypes and locomotor activity between male and female rats.

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Section: Introductionmentioning

confidence: 78%

Differential Effects of Valproic Acid on Immobility Responses and Locomotor Activity in Female and Male Rats

Morales-Dionisio¹,

Cruz²,

Franco-Colín³

et al. 2017

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“…In series 2 rat pups (pnd 6) from each litter were treated with either saline or valproic acid injections (Sigma Aldrich, USA) dosed at 150 mg/kg intraperitoneally (“Control” and “VPA” group respectively) once each day for 1 week (pnds 6–12). VPA-induced model of ASD was selected as it is the most common model of induction of autism-like behaviors in rodents [33, 34]. On pnd 12 rat pups were acclimated to the gas exposure apparatus for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

et al. 2019

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BackgroundXenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluation of this gas for treatment of CNS pathologies, including psychoemotional disorders. The aim of this study was to assess the behavioral effects of acute inhalation of subanesthetic concentrations of Xe and to study the outcomes of Xe exposure in valproic acid (VPA)-induced rodent model of autism.MethodsWe have conducted two series of experiments with a battery of behavioral tests aimed to evaluate locomotion, anxiety- and depression-like behavior, and social behavior in healthy, VPA-treated and Xe-exposed young rats.ResultsWe have shown that in healthy animals Xe exposure resulted in acute and delayed decrease of exploratory motivation, partial decrease in risk-taking and depressive-like behavior as well as improved sensorimotor integration during the negative geotaxis test. Acute inhalations of Xe in VPA-exposed animals led to improvement in social behavior, decrease in exploratory motivation, and normalization of behavior in forced-swim test.ConclusionBehavioral modulatory effects of Xe are probably related to its generalized action on excitatory/inhibitory balance within the CNS. Our data suggest that subanesthetic short-term exposures to Xe have beneficial effect on several behavioral modalities and deserves further investigation.

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Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models

Gedzun

Khukhareva

Sarycheva

et al. 2023

Neurosci Behav Physi

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Fetal valproate syndrome as an experimental model of autism

Cited by 4 publications

References 23 publications

Differential Effects of Valproic Acid on Immobility Responses and Locomotor Activity in Female and Male Rats

Differential Effects of Valproic Acid on Immobility Responses and Locomotor Activity in Female and Male Rats

Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models

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