Fetal skeletal size and growth are relevant biometric markers in Vitamin D deficient mothers: A North East India prospective cohort study

Sarma, Debajit; Saikia, Uma Kaimal; Das, Darvin V

doi:10.4103/ijem.ijem_652_17

Cited by 12 publications

(7 citation statements)

References 22 publications

(33 reference statements)

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“…The results of the study by Abalos E. et al and Abdel-Aleem H. et al also in agreement with current study where they reported Open Journal of Obstetrics and Gynecology calcium supplementation has no effect on fetal birth weight [51] [52]. Thoughfew studies have shown calcium intake during pregnancy has a positive effect on the fetal birth weight [53] [54]. The study results also showed significant negative correlation between Proteinuria and fetal birth weight (r = −0.514, p < 0.001).…”

Section: Discussionsupporting

confidence: 90%

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Gadde¹,

Doddaiah²,

Rangappa³

2018

OJOG

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Preeclampsia is a pregnancy complication; early identification with increased risk is one of the key goals in obstetrics. In a nested case control study, serum uric acid and calcium measured in first and second trimesters of pregnancy were correlated with Xanthine oxidase (XO) activity, mean arterial pressure (MAP) and fetal birth weight. The mean ± SD of uric acid (2.01 ± 0.85, 4.8 ± 1.93), calcium (10.88 ± 1.97, 9.72 ± 2.04), MAP (84.32 ± 6.71, 78.40 ± 8.53) and XO activity (11.96 ± 1.91, 14.05 ± 3.09) of the study group (n=86) were observed in the first and second trimesters respectively. First trimester normotensive group (n=79) and preeclampsia cases (n = 7), showed a mean ± SD of uric acid (1.93 ± 0.80, 2.9 ± 0.88), Calcium (10.92 ± 1.9, 10.6 ± 1.72), MAP (84.19 ± 6.75, 85.71 ± 6.58) XO activity (11.82 ± 1.83, 13.57 ± 2.21). In the second trimester, normotensive group and preeclampsia cases showed a mean ± SD uric acid (4.6 ± 1.75, 7.3 ± 2.19), Calcium (9.4 ± 1.85, 12.9 ± 1.04), MAP (76.41 ± 5.41, 100.95 ± 2.52) and XO activity (13.37 ± 1.93, 21.70 ± 3.50). Statistical analysis revealed a non-significant positive correlation in first trimester between uric acid and MAP (r = +0.116, p = 0.288), negative correlations between uric acid and fetal birth weight (r = −0.118, 0.279) and between calcium and MAP (r = −0.288, p = 0.007). In the second trimester, significant positive correlations were observed between uric acid (r = +0.246, p = 0.022), calcium (r = +0.326, p = 0.007) with MAP along with a significant negative correlation between uric acid (r = −0.641, p = 0.000), calcium (r = −0.316, p = 0.003), Proteinuria (r = −0.514, p = 0.000) with fetal birth weight. The screening of first and second trimesters XO activity, uric acid, calcium and MAP during pregnancy is beneficial in identifying women likely to develop

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Section: Discussionsupporting

confidence: 90%

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Gadde¹,

Doddaiah²,

Rangappa³

2018

OJOG

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“…However, when analysis was restricted to Europeans only, associations attenuated for some of the outcomes. Similarly, in their study Sarma et al [ 44 ], assessing maternal Vit-D levels of 250 pregnancies during third trimester in India, found that fetal femur length at 34 weeks, as well as birth length, were significantly shorter in mothers with low Vit-D serum levels, while no significant differences were found regarding fetal birth weight and head circumference.…”

Section: Resultsmentioning

confidence: 85%

“…Given that Vit-D is either synthesized by human skin cells or obtained through diet, its levels may also reflect a crude measure of maternal nutritional status. For example, populations of low socioeconomic status residing in developing countries seem to have high Vit-D deficiency rates, as multiple studies report [ 37 , 44 , 86 , 88 ]. Furthermore, maternal hyperphagia or sub-optimal nutrition during gestation can also influence fetal growth and neonatal anthropometric indices, as well as fat deposition in offspring irrespectively of maternal Vit-D status [ 107 ].…”

Section: Resultsmentioning

confidence: 99%

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

Dimas

Politi

Bargiota

et al. 2022

IJMS

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Fetal exposure in adverse environmental factors during intrauterine life can lead to various biological adjustments, affecting not only in utero development of the conceptus, but also its later metabolic and endocrine wellbeing. During human gestation, maternal bone turnover increases, as reflected by molecules involved in bone metabolism, such as vitamin D, osteocalcin, sclerostin, sRANKL, and osteoprotegerin; however, recent studies support their emerging role in endocrine functions and glucose homeostasis regulation. Herein, we sought to systematically review current knowledge on the effects of aforementioned maternal bone biomarkers during pregnancy on fetal intrauterine growth and metabolism, neonatal anthropometric measures at birth, as well as on future endocrine and metabolic wellbeing of the offspring. A growing body of literature converges on the view that maternal bone turnover is likely implicated in fetal growth, and at least to some extent, in neonatal and childhood body composition and metabolic wellbeing. Maternal sclerostin and sRANKL are positively linked with fetal abdominal circumference and subcutaneous fat deposition, contributing to greater birthweights. Vitamin D deficiency correlates with lower birthweights, while research is still needed on intrauterine fetal metabolism, as well as on vitamin D dosing supplementation during pregnancy, to diminish the risks of low birthweight or SGA neonates in high-risk populations.

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“…Approximately 25e30 g of calcium are transferred to the fetal skeleton by the end of pregnancy, most of which is transferred during the last trimester [42]. The 3 possible calcium sources that may supply the mother with the necessary calcium to support fetal growth include increased intestinal absorption from the diet, increased renal conservation, and increased bone mobilization [43]. It has been estimated that the fetus accumulates up to 250 mg/d calcium during the third trimester.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D in pregnancy and after 15 days of delivery along with neonatal

Mehrotra

Sandhu

Nautiyal

2019

Clinical Nutrition Experimental

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Background &aims: India, where sunshine is abundant throughout the year, the extent of VD deficiency have been reported ranging from 50% to 86.5% for neonatal and young infants, which is still huge. The high prevalence of VD deficiency during pregnancy is increasingly recognized, especially in women, following customs like a veil. Uttarakhand located at the foothills of Himalayas is the totally socio-culturally diverse state with higher population density in the plain region like Dehradun, India. Methods: To understand the differences in VD status we evaluated 25 (OH) D levels in three trimesters of pregnancy and at birth in neonatal serum and cord blood along with 15 days of life born within our hospital along with mother respectively. Results: The study demonstrated a high prevalence of VD levels at the time of pregnancy. The studied reflects a deficiency of serum VD in the first trimester 18 ± 6 ng/ml, while in second and third trimester VD levels were more 38 ± 3 and 41 ± 4 ng/ml respectively as compared to first. There was a significant difference in VD status due to the presence of supplementation in both cord blood and in neonatal serum. There are many traditional factors which contributed to the observation of the high occurrence of VD deficiency in this study. Identifying VD deficiency at pregnancy time and after birth should be essential for the growth of public policy for anticipation and supplementation. Conclusions: The study demonstrated a high prevalence of VD status with significant differences due to the existence of supplementation. There are many traditional factors which contributed to the observation of the high occurrence of VD deficiency in this study. Identifying VD deficiency at pregnancy time and after birth

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Fetal skeletal size and growth are relevant biometric markers in Vitamin D deficient mothers: A North East India prospective cohort study

Cited by 12 publications

References 22 publications

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

Association of vitamin D in pregnancy and after 15 days of delivery along with neonatal

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