Fetal neural tissue and stem cell grafts may induce regenerative plasticity in damaged mammalian brain

Ourednik, Jitka; Ourednik, Václav; Snyder, Evan Y.

doi:10.1016/s1566-2772(02)00009-9

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are classified as embryonic and adult according to their origin. Since the first embryonic stem cell growth in culture medium in 1998, experimental studies and investigations related to stem cell treatment have been conducted on many neurological degenerative disorders mainly spinal cord injuries, cerebral infarct, Parkinson disease, AD (83)(84)(85)(86)(87)(88)(89)(90)(91). Mainly two stem cell types are used: pluripotent stem cell/induced pluripotent stem cell originated from embryonic stem cell, and adult stem cells (neuronal stem cells, hematopoietic stem cells, mesenchymal stem cells).…”

Section: Discussionmentioning

confidence: 99%

Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Can¹,

Barlas²

2019

BMB

View full text Add to dashboard Cite

It is known that the acetylcholinergic afferents of the neocortex from subcortical areas participate in learning and memory. Autopsy studies in cases of Alzheimer's disease (AD) have shown that most of the neurons of nucleus basalis magnocellularis (NBM) are atrophic or decreased in number. In this study, we searched for whether or not it was possible to improve the impaired learning and memory functions with foetal neural tissue transplantation in an experimental model of AD. Method: A total of thirty seven young adult male Wistar albino rats were served as experimental subjects. NBM on the right side was destroyed by the injection of kainic acid stereotactically so as to make a model of AD. The grafts were obtained from 14-16 day foetuses of the same genus. After the tissue with cholinergic neurons dissected from ventral forebrain and tissue with non-cholinergic neurons dissected from telencephalic vesicle, cell suspensions were prepared and injected stereotactically to the ipsilateral frontal cortex. Spatial learning and memory functions were tested by Morris' water maze tasks. Results: Spatial learning and memory functions in rats were impaired by unilateral lesions of nucleus basalis magnocellularis. The impairment observed during the early period partially improved by the time. It was observed that this amelioration was accelerated with both cholinergic and non-cholinergic foetal neural tissue implantation. Amaç: Subkortikal alanlardan neokortekse uzanan asetilkolinerjik nöronların öğrenme ve bellek süreçlerinde rol aldığı bilinmektedir. Alzheimer hastalığında (AH) yapılan otopsi incelemeleri bazal magnoselüler çekirdekteki nöronlarda atrofi veya azalma olduğunu göstermiştir. Bu çalışmada deneysel AH modelinde bozuk öğrenme ve bellek fonksiyonlarının, fötal nöral doku transplantasyonu ile düzelmesinin mümkün olup olmadığı araştırıldı. Yöntem: Deneysel çalışmada 37 adet Wistar albino cinsi genç erişkin erkek sıçan kullanıldı. AH modeli sağ bazal magnoselüler çekirdeğe stereotaktik yöntemle verilen, nörotoksik bir ajan olan kainik asit ile oluşturuldu. Greftler aynı cins sıçanların 14-16 günlük fetuslarından alındı. Kolinerjik nöronları içeren doku ventral ön beyinden, non-kolinerjik nöronların olduğu doku ise telensefalik vezikülden elde edilerek, hücre süspansiyonu haline getirildi ve stereotaktik yöntemle ipsilateral frontal kortekse implante edildi. Hacimsel öğrenme ve bellek fonksiyonları Morris'in "water maze" testi ile değerlendirildi. Bulgular: Tek taraflı bazal magnoselüler nükleus lezyonları ile sıçanlarda hacimsel öğrenme ve bellek fonksiyonları bozuldu. Erken dönemde bozulan bu fonksiyonlar geç dönemde kısmen düzeldi. Hem kolinerjik hem de non-kolinerjik fötal doku implantasyonu ile bu düzelmenin hızlandığı saptandı.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Can¹,

Barlas²

2019

BMB

View full text Add to dashboard Cite

show abstract

“…Until todays, in human, dopaminergic cell transplantation was performed more than 300 cases in Parkinson's disease. The implants adapted with tissue and their continued viability has been proven with PET-scan and clinical improvement [41,42]. Embryonic stem cells (ESCs) also had been source for cell replacement therapy in PD.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Stem Cell Therapy in the Treatment of Neurological Diseases

Kocaoğlu¹,

Korucu²,

Civlan³

et al. 2014

rain Disord Ther

View full text Add to dashboard Cite

Before a half century, regeneration of neurons has been admitted as an impossible event. Thus, neurodegenerative disorders (e.g. Parkinson's disease, Alzheimer's disease, multiple sclerosis), vascular events (e.g. stroke) and traumatic diseases (e.g. spinal cord injury) have been admitted as incurable diseases. Afterward, tissue reparative and regenerative potential of stem cell researches for these disorders drew attention of the scientist to replacement therapy. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment methods is cell transplantation. For this purpose many types of stem cells such as mononuclear stem cells, mesenchymal stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for these neurologic disorders. In this article, we reviewed stem cell treatment modalities for neurological disorders in the light of current literature.

show abstract

Fetal neural tissue and stem cell grafts may induce regenerative plasticity in damaged mammalian brain

Cited by 2 publications

References 18 publications

Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Improvement of Spatial Learning and Memory Impairments by Fetal Neural Tissue Transplantation in Experimental Rat Model of Alzheimer’s Disease

Stem Cell Therapy in the Treatment of Neurological Diseases

Contact Info

Product

Resources

About