Stem Cell Therapy in the Treatment of Neurological Diseases

Abstract

Before a half century, regeneration of neurons has been admitted as an impossible event. Thus, neurodegenerative disorders (e.g. Parkinson's disease, Alzheimer's disease, multiple sclerosis), vascular events (e.g. stroke) and traumatic diseases (e.g. spinal cord injury) have been admitted as incurable diseases. Afterward, tissue reparative and regenerative potential of stem cell researches for these disorders drew attention of the scientist to replacement therapy. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment methods is cell transplantation. For this purpose many types of stem cells such as mononuclear stem cells, mesenchymal stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for these neurologic disorders. In this article, we reviewed stem cell treatment modalities for neurological disorders in the light of current literature.

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

“…Stem cell-based therapy is a promising, safe, and effective therapeutic strategy for several neurodegenerative diseases, including AD (Kocaoglu et al 2014;Chang et al 2014;Wernig et al 2008). Stem cellbased-approach is still under development but rapid achievements indicate its therapeutic potential for reversing AD-associated neurodegeneration, as well as, improving cellular and structural functions (Lee et al 2015;Kwak et al 2018).…”

“…Therefore, regenerative therapy, using stem cells, could be regarded as a promising and safe approach for regeneration of altered or lost cellular functions (Kocaoglu et al 2014). Although the underlying mechanisms of stem cell-based therapy need more clarification, there are several preclinical studies demonstrated encouraging results (Kwak et al 2018).…”