Fetal limb soft tissue assessment for prediction of birth weight and umbilical cord blood analytes in gestational diabetes

Garcia-Flores, Jose; Cruceyra, Mireia; Cañamares, Marina; Garicano, Ainhoa; Nieto, Olga; López, A; Dorronsoro, Izaskun; Tamarit, I.; Cuesta, Ricardo Sáinz de la

doi:10.1002/pd.4669

Cited by 5 publications

(4 citation statements)

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“…This relationship is not exactly a 2:1 ratio due to compression of the tissue by the caliper, and may have contributed to the weak correlations in our analysis. Fetal thigh and arm circumferences and volumes utilising both two‐ and three‐dimensional ultrasound techniques have shown the most promising results, improving the predictive value of both macrosomia and infant birthweight in women with obesity and diabetes . There is a clear need for prospective studies with robust methodology, consistency in fetal and neonatal measurement and large sample sizes to further delineate the predictive value of fetal and neonatal adiposity.…”

Section: Discussionmentioning

confidence: 99%

In overweight and obese women, fetal ultrasound biometry accurately predicts newborn measures

O’Brien

Louise

Deussen

et al. 2019

Aust NZ J Obst Gynaeco

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Introduction The aim of this study was to evaluate the association between fetal ultrasound and newborn biometry and adiposity measures in the setting of maternal obesity. Material and Methods The study population involved 845 overweight or obese pregnant women, who participated in the Standard Care Group of the LIMIT randomised trial (ACTRN12607000161426, 9/03/2007). At 36 weeks gestation, fetal biometry, estimated fetal weight (EFW) and adiposity measures including mid‐thigh fat mass (MTFM), subscapular fat mass (SSFM), and abdominal fat mass (AFM) were undertaken using ultrasound. Neonatal anthropometric measurements obtained after birth included birthweight, head circumference (HC), abdominal circumference (AC) and skinfold thickness measurements (SFTM) of the subscapular region and abdomen. Results At 36 weeks gestation, every 1 g increase in EFW was associated with a 0.94 g increase in birthweight (95% CI 0.88–0.99; P < 0.001). For every 1 mm increase in the fetal ultrasound measure, there was a 0.69 mm increase in birth HC (95% CI 0.63–0.75, P < 0.001) and 0.69 mm increase in birth AC (95% CI 0.60–0.79, P < 0.001). Subscapular fat mass in the fetus and the newborn (0.29 mm, 95% CI 0.20–0.39, P < 0.001) were moderately associated, but AFM measurements were not (0.06 mm, −0.03 to 0.15, P = 0.203). There is no evidence that these relationships differed by maternal body mass index. Conclusion In women who are overweight or obese, fetal ultrasound accurately predicts neonatal HC and AC along with birthweight.

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Section: Discussionmentioning

confidence: 99%

In overweight and obese women, fetal ultrasound biometry accurately predicts newborn measures

O’Brien

Louise

Deussen

et al. 2019

Aust NZ J Obst Gynaeco

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“…Three-dimensional volumes from the fetal upper limb (arm) and lower limb (thigh) were obtained as described previously. 10 The fractional limb volumes were calculated using the 4D View software based on the central 50% of the diaphysis length. The crosssectional area was outlined in the middle sectional plane of the diaphysis.…”

Section: Methodsmentioning

confidence: 99%

“…Previous works have related the glycemic maternal control in gestational diabetes to diverse fetal changes, as increased fat tissue deposits in fetal limbs or increased fetal liver size . There are no studies yet examining the influence of maternal hyperglycemia on the ultrasonographic features of the fetal adrenal gland.…”

mentioning

confidence: 99%

“…[2][3][4] Other studies have demonstrated profound changes in the function and the morphology of the fetal adrenal gland in altered nutritional states-primarily undernutrition and/or intrauterine growth restriction in human and animal models. [5][6][7][8][9] Previous works have related the glycemic maternal control in gestational diabetes to diverse fetal changes, as increased fat tissue deposits in fetal limbs 10 or increased fetal liver size. 11 There are no studies yet examining the influence of maternal hyperglycemia on the ultrasonographic features of the fetal adrenal gland.…”

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confidence: 99%

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