Fetal Leukocytes in the Maternal Circulation After Delivery

Peripheral blood mononuclear cell microchimerism in Turkish female patients with systemic sclerosis

“…The mean age of the women at their first birth was 26.21 ± 3.8 (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) years in the control group, 24.92 ± 5.1 years in the dcSSc patient group and 24.11 ± 3.8 (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) years in the lcSSc patient group. There was no significant difference with respect to the age (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) in the dcSSc patients and 10 (4-24) in the lcSSc patients, which was a significant difference (p \ 0.05).…”

Gender differences in stem cell population are induced by pregnancy

“…Detection of cells of fetal and placental origin in maternal blood during and after pregnancy has been well documented over the past decades [1]. For example, trophoblast-like cells and Y chromosome-carrying fetal leukocytes were regularly detected in maternal blood after delivery [1,2]. Male progenitor cells (CD34+ and CD34+ CD38+ cells) have been detected in maternal circulation for several decades after pregnancy as reported by Bianchi et al [3,4].…”

Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients

“…During pregnancy, a bidirectional cell transfer, from mother to child and vice versa, may result in persisting fetal cells in the mother (fetal microchimerism), which are detectable as long as three decades after birth. 8,9 Hence, we hypothesized that (i) fetal microchimerism (FM) has a role in hHSCT and that (ii) FM may be influenced by the killer immunoglobulin-like receptors (KIRs) pattern on maternal natural killer (NK) cells and KIR ligands on the child's cells. CD56 bright NK cells make up~70% of the lymphocytes in the decidua during the first trimester of pregnancy and represent the major cell subset interacting with cells of the developing fetus.…”