Peripheral blood mononuclear cell microchimerism in Turkish female patients with systemic sclerosis

Şahin, Ali; Özkan, Tülin; Türkçapar, Nuran; Küçükşahin, Orhan; Köksoy, Elif Berna; Özturk, Gülşah; Erten, Şükran; Sunguroğlu, Asuman; Turgay, Murat; Kınıklı, Gülay

doi:10.3109/14397595.2013.854052

Cited by 5 publications

(3 citation statements)

References 34 publications

(84 reference statements)

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“…QuestionnaireNo significant relationship was found for either birth order or family size with SSc. SSc patients were more likely to be multiparous than controls (OR = 1.8; 95% CI: 1.1, 2.98)Şahin et al 2013 Turkey [64] Case–control. 80 female SSc patients and 40 healthy female controlsMicrochimerism and parity.…”

Section: Resultsmentioning

confidence: 99%

“…The possible effects of microchimerism as a risk factor for SSc were investigated in eight of the articles included in this review [12, 47, 48, 53, 59, 61, 63, 64]. Five of these articles reported microchimerism as being more common in SSc patients than in controls and found a positive relationship between SSc and a history of pregnancy (especially a history of having had a son) [47, 48, 53, 59, 64]. The other three studies failed to show a relationship and argued against microchimerism as a risk factor [12, 61, 63].…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for the development of systemic sclerosis: a systematic review of the literature

Abbot

Bossingham

Proudman

et al. 2018

Rheumatology Advances in Practice

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Objectives Although numerous studies have investigated the roles of various genetic, epigenetic and environmental factors that may impact its aetiology, SSc is still regarded as an idiopathic disease. Given that there is significant heterogeneity in what has been proposed to influence the development of SSc, this systematic review was conducted to assess the impacts of different factors on the aetiology of scleroderma. Methods The search was performed in the PubMed, CINAHL and SCOPUS databases on 17 May 2017. Any study that made explicit reference to scleroderma or SSc that had information about the risk factors or epidemiology of the disease was included. The extracted outcome variables were prevalence, gender preponderance, geographical distribution, family history and various proposed environmental risk factors. Results One thousand five hundred and seventy-four articles were screened for eligibility. Thirty-four articles were eligible for the systematic literature review. Conclusion Age between 45 and 64 years, female sex, positive family history and exposure to silica were found to be risk factors. There were conflicting findings regarding the impact of exposure to organic solvents and microchimerism. No relationship between infectious agents, alcohol consumption or cigarette smoking and the development of SSc was identified.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Risk factors for the development of systemic sclerosis: a systematic review of the literature

Abbot

Bossingham

Proudman

et al. 2018

Rheumatology Advances in Practice

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“…In their study on the association of Mc with clinical subsets of scleroderma, Sahin et al concluded that Mc can shorten the elapsed time of disease development in scleroderma patients; however, it was determined to have no association with clinical presentations of the disease [9]. On the other hand, another investigation into the effects of number of parities and gender of children on the epidemiology and pathogenesis of scleroderma detected no sig-doi: 10.22631/rr.2019.69997.1061…”

Section: Introductionmentioning

confidence: 99%

The Effect of Microchimerism on Frequency and Severity of Organ Involve- ment in Iranian Scleroderma Patients

et al. 2019

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Microchimerism is defined as the presence of non-self and circulating cells in a host. The current study aimed to assess the effect of microchimerism on scleroderma major organ involvements. This cross-sectional study was conducted on 56 scleroderma patients registered in a tertiary rheumatology center of Shiraz University of Medical Sciences. Information on the patients' demographics and disease complications was gathered through a review of medical records. Skin score was applied to better assess skin thickening. High Resolution CT-scan as well as pulmonary function test (PFT) results were also used to investigate pulmonary involvement in patients. Y chromosome serum levels were measured using Phenol Chloroform Extraction protocol and following real-time PCR. Fifty-six scleroderma patients with a mean age of 46±10 years were recruited in this study (58.9% with diffuse scleroderma and 41.07% with limited scleroderma). Other than skin thickening, the most common clinical presentation among the patients was interestitial lung disease (67.8%). No significant difference was found between Y chromosome levels of patients with either lung, cardiac, renal, or gastrointestinal involvement and those who did not have these complications. Y chromosome serum levels based on the results of PFT were also shown to have no significant difference. Moreover, no association was demonstrated between serum Y chromosome and skin score. The serum level of chromosome Y has no impact on the severity and frequency of major organ involvement in Iranian scleroderma patients.

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Autoimmune Disease

Lambert¹

2018

Chimerism

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Peripheral blood mononuclear cell microchimerism in Turkish female patients with systemic sclerosis

Cited by 5 publications

References 34 publications

Risk factors for the development of systemic sclerosis: a systematic review of the literature

Risk factors for the development of systemic sclerosis: a systematic review of the literature

The Effect of Microchimerism on Frequency and Severity of Organ Involve- ment in Iranian Scleroderma Patients

Autoimmune Disease

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