Fetal growth retardation associated with inadequate haemodilution in otherwise uncomplicated pregnancy

Koller, O; Sagen, Norvald; Ulstein, Magnar; Vaula, Dag

doi:10.3109/00016347909154904

Cited by 52 publications

(28 citation statements)

References 18 publications

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“…In addition, failure of plasma volume expansion (or high Hgb) was associated with increased risk of fetal growth restriction. [30][31][32][33] Therefore, the plasma volume expansion and consequent "anemia" are associated with fewer low-birth-weight and preterm-birth deliveries.…”

Section: Discussionmentioning

confidence: 99%

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Xiong¹,

Buekens²,

Alexander³

et al. 2000

Amer J Perinatol

158

114

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To determine the relationship between maternal anemia [hemoglobin (Hgb) < 10-11 g/dL] and various birth outcomes, a meta-analysis was conducted based on published literature identified by MEDLINE and manual search from 1966 through 1999. Odds ratios (OR) from selected studies were pooled according to the gestational age at anemia diagnosis. The meta-analysis shows that maternal anemia during early pregnancy was associated with slightly increased preterm birth [pooled adjusted OR (aOR): 1.32, 95% confidence interval (CI): 1.01-1.74], and nonstatistically significant increased low birth weight [pooled aOR: 1.39 (0.70-2.74)], and was not associated with fetal growth restriction [pooled aOR: 1.01 (0.73-1.38)]. However, there was a nonstatistically significant inverse relationship between anemia during late pregnancy and preterm birth [pooled aOR: 0.92 (0.54-1.84)] and low birth weight [pooled aOR: 0.80 (0.64-1.00)]. Anemia was not statistically significantly associated with hypertensive disorders of pregnancy regardless of stage of pregnancy [pooled OR: 0.80 (0.53-1.20)]. The relationship between anemia and perinatal mortality was inconclusive. A few studies indicated that severe maternal anemia (Hgb < 8-8.5 g/dL) was associated with increased risk of poor outcomes. We conclude that early pregnancy anemia is associated with slightly increased risk of preterm birth. The trend toward an inverse association of anemia determined during late pregnancy with preterm birth and low birth weight may reflect the benefit of plasma volume expansion.

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Section: Discussionmentioning

confidence: 99%

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Xiong¹,

Buekens²,

Alexander³

et al. 2000

Amer J Perinatol

158

114

View full text Add to dashboard Cite

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“…Maternal anemia has long been considered a risk factor for poor pregnancy outcome [1][2][3]. In addition, elevated hemoglobin levels have also emerged as being predictive of intrauterine growth restriction (IUGR) [1,[3][4][5][6][7][8]. An inverse association between elevated second-or third-trimester hemoglobin levels and fetal weight has been established in a general cohort of women in multiple studies [1,[3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Maternal hemoglobin concentration and its association with birth weight in newborns of mothers with preeclampsia

Amburgey¹,

Ing²,

Badger

et al. 2009

DJMF

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OBJECTIVE Maternal hemoglobin concentration is inversely related to newborn size presumably through plasma volume constriction. We sought to determine whether birth weight would show an inverse relationship to hemoglobin concentration in a group of infants whose mothers had preeclampsia, where plasma volume constriction is common. METHODS Electronic and paper chart review identified 142 nulliparous women with preeclampsia (excluding HELLP syndrome). Birth weight percentile was determined based on cross-sectional hybrid growth curves. Maximal third trimester maternal hemoglobin concentrations were obtained and standardized to z-scores based on gestational age matched normative data. Birth weight percentile was examined as a function of hemoglobin z-score using appropriate statistics. RESULTS Average gestational age at delivery was 35.9±1.9 weeks. Mean birth weight percentile for infants of preeclamptic mothers was 34±32. Mean hemoglobin z-score for mothers with preeclampsia was 0.3±1.5, significantly higher than a control population (p = 0.04). Maternal hemoglobin z-score was inversely associated with birth weight percentile (r = − 0.18, P = 0.03). CONCLUSION Maternal hemoglobin concentrations are significantly elevated prior to delivery in women with preeclampsia. There is a statistically significant inverse correlation of maternal hemoglobin concentration to birth weight percentile.

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“…11 Few of the studies have also shown that increase in the Hb beyond a certain level could in fact have a negative outcome. 12 Objective of present study was to find association between maternal anaemia and neonatal complications and to find long term morbidity and mortality of babies born to anaemic mothers. …”

Section: Introductionmentioning

confidence: 99%

Effect of anemia on pregnancy outcome: a prospective study at tertiary care hospital

Upadhyay

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Iron deficiency anaemia during pregnancy leads to preterm birth, low birth weight and small-for-gestational age babies and increases incidence of postpartum haemorrhage (PPH) and the reason for the incidence of PPH is higher in India compared with the rest of the world. The objective of this study was to find association between maternal anaemia and neonatal complications and to find long term morbidity and mortality of babies born to anaemic mothers.Methods: It is a prospective study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore during October 2009 to October 2011. All subjects were analyzed in full details and haemoglobin estimation done during 1st visit, at 30th week and 36th week of gestation.Results: Study observed moderate anaemia observed in almost 53.0% cases followed by mild (29.5%) and severe (17.5%) respectively. Risk factors present in 58.0% cases and maternal complications in puerperium observed in 14.5% cases. High incidence of adverse foetal outcome in the form of preterm (20%), IUGR (28%), NICU admission (25.5%) and IUD (3%) seen in present study. Study found association between space between pregnancy, LSCS and fetal outcome with severity of anaemia. Ensuring maternal iron sufficiency during gestation is the most cost-effective method of preventing perinatal iron deficiency and related morbidities.Conclusions: Iron supplementation during pregnancy in iron deficient mothers improves iron status during pregnancy and postpartum period, thus providing some protection against iron deficiency in the subsequent pregnancy. Proper antenatal care is the basic requirement for prevention, early detection and treatment of anaemia.

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Fetal growth retardation associated with inadequate haemodilution in otherwise uncomplicated pregnancy

Cited by 52 publications

References 18 publications

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Maternal hemoglobin concentration and its association with birth weight in newborns of mothers with preeclampsia

Effect of anemia on pregnancy outcome: a prospective study at tertiary care hospital

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