Fetal growth restriction: Case definition &amp; guidelines for data collection, analysis, and presentation of immunization safety data

Easter, Sarah Rae; Eckert, Linda O.; Boghossian, Nansi S.; Spencer, Rebecca; Oteng‐Ntim, Eugene; Ioannou, Christos; Patwardhan, Manasi; Harrison, Margo S.; Khalil, Asma; Gravett, Michael G.; Goldenberg, Robert L.; McKelvey, Alastair; Gupta, Manish; Pool, Vitali; Robson, Stephen C.; Joshi, Jyoti; Kochhar, Sonali; McElrath, Tom

doi:10.1016/j.vaccine.2017.01.042

Cited by 26 publications

(25 citation statements)

References 68 publications

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“…All the participants were followed-up till their discharge and various data were recorded. Adverse fetal outcomes included fetal growth restriction (FGR) (Easter et al, 2017), perinatal asphyxia (Silveira and Procianoy, 2015), stillbirth (Blencowe et al, 2016), and so on. Adverse maternal outcomes were defined as placenta abruption (Elsasser et al, 2010), disseminated intravascular coagulation (DIC) (Wada et al, 2013), eclampsia (American College of Obstetricians and Gynecologists and Task Force on Hypertension in Pregnancy, 2013), hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome (American College of Obstetricians and Gynecologists and Task Force on Hypertension in Pregnancy, 2013), and so on.…”

Section: Groupingmentioning

confidence: 99%

Long Non-coding RNA Gas5 Is Associated With Preeclampsia and Regulates Biological Behaviors of Trophoblast via MicroRNA-21

Zheng

Hou

et al. 2020

Front. Genet.

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Preeclampsia is a lethal pregnancy specific hypertensive disorder involving multisystem. Despite extensive studies to investigate the causes of preeclampsia, the pathogenesis still remains largely unknown. Long non-coding RNAs (lncRNAs) are a diverse class of non-translated RNAs which play a crucial part in various biological phenomena. Although lncRNA Growth Arrest-Specific 5 (GAS5) aberrantly expressed in multiple cancer tissues and is implicated in multiple biological processes of tumor cells, little is known about its role in preeclampsia. In this study, 40 patients with preeclampsia and 32 gestational age matched normotension pregnant women were recruited. Using quantitative real-time polymerase chain reaction (qRT-PCR), we found higher expression of GAS5 in placenta of preclamsia affected women. The level of GAS5 existed strongly in correlation with Thrombin Time indicating coagulation function and other clinical parameters by Pearson correlation analysis. Then we constructed the GAS5 lentivirus expression vectors and transfected into human trophoblast cell lines HTR-8/SVneo and JEG-3. Using in vitro cell culture studies, we found an inhibited effect of GAS5 on proliferative ability, migratory ability and invasive ability however; no effect on apoptosis was detected. Further mechanistic analysis found that GAS5 modulated microRNA-21 (miR-21) in an opposite variation tendency by qRT-PCR and rescue experiment. In addition, inhibition of GAS5 promoted the activation of PI3K/AKT signaling pathway and its downstream proteins covering MMP-9 and TP53 as evident from our qRT-PCR and western blot analyses. Thus, we suggested that GAS5 might involve in pregnancy with preeclampsia by influencing the biological functions of trophoblast cells through the regulation of miR-21 and activation of PI3K/AKT signaling pathway and its downstream targets, which may contribute to reveal the nature of preeclampsia.

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Section: Groupingmentioning

confidence: 99%

Long Non-coding RNA Gas5 Is Associated With Preeclampsia and Regulates Biological Behaviors of Trophoblast via MicroRNA-21

Zheng

Hou

et al. 2020

Front. Genet.

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“…Intrauterine Growth Restriction IUGR fetuses do not grow according to their genetic growth potential, which can be caused by impaired placentation including utero-placental vascular insufficiency [7,87]. When over a third of the fetal villous vasculature is abnormal, the Doppler resistance indices indicate an increase in impedance to flow and resistance in the umbilical artery [88].…”

Section: Impact Of Pregnancy Complications On Early Cardiac Remodelingmentioning

confidence: 99%

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

Tan

Lewandowski²

2019

Fetal Diagn Ther

173

123

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Formation of the human heart involves complex biological signals, interactions, specification of myocardial progenitor cells, and heart tube looping. To facilitate survival in the hypoxemic intrauterine environment, the fetus possesses structural, physiological, and functional cardiovascular adaptations that are fundamentally different from the neonate. At birth, upon separation from the placental circulation, the neonatal cardiovascular system takes over responsibility of vital processes for survival. The transition from the fetal to neonatal circulation is considered to be a period of intricate physiological, anatomical, and biochemical changes in the cardiovascular system. With a successful cardiopulmonary transition to the extrauterine environment, the fetal shunts are functionally modified or eliminated, enabling independent life. Investigations using medical imaging tools such as ultrasound and magnetic resonance imaging have helped to define normal and abnormal patterns of cardiac remodeling both in utero and ex utero. This has not only allowed for a better understanding of how congenital cardiac malforma-tions alter the hemodynamic transition to the extrauterine environment but also how other more common complications during pregnancy including intrauterine growth restriction, preeclampsia, and preterm delivery adversely affect offspring cardiac remodeling during this early transitional period. This review article describes key cardiac progenitors involved in embryonic heart development; the cellular, physiological, and anatomical changes during the transition from fetal to neonatal circulation; as well as the unique impact that different pregnancy complications have on cardiac remodeling.

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“…Small for gestational age (SGA) represents birthweight less than two standard deviations below the mean or birth weight under the10 th percentile on population-specificnomograms for a specified gestational age [2]. Both entities are clearly defined, but sometimes these two terms are used interchangeably [3]. IUGR is diagnosed prenatally based on the ultrasound measurement of fetal bi-ometry under the 10 th centile for the gestational age with associated umbilical artery and/or middle cerebral artery colour Doppler abnormalities [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Both entities are clearly defined, but sometimes these two terms are used interchangeably [3]. IUGR is diagnosed prenatally based on the ultrasound measurement of fetal bi-ometry under the 10 th centile for the gestational age with associated umbilical artery and/or middle cerebral artery colour Doppler abnormalities [3,4].…”

Section: Introductionmentioning

confidence: 99%

Cardiac left heart morphology and function in newborns with intrauterine growth restriction: relevance for long-term assessment

et al. 2019

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Aim: To asses the cardiac morphology and functional changes specific for newborns from intrauterine growth restriction (IUGR) pregnancies.Material and method: A cohort of IUGR infants were evaluated by serial echocardiographies at delivery and at the first and six months follow-ups. IUGR newborn delivery status was compared to that of newborns in the control group according to gestational age (AGA).Results: Left heart measurements were significantly lower in IUGR newborns compared to AGA babies. Left ventricular size increased at follow-up inthe IUGR group (p<0.05). Systolic dysfunction (the myocardial performance index (MPI)> 0.47) was identified in 40% of the neonates in the IUGR group (16/40), respectively 4.76% in the control group. IUGR neonates had a significantly increased proportion of systolic malfunction (p=0.004).Conclusion: IUGR patients had reduced left ventricle dimensions compared to AGA babies. The MPI stands out as a marker of leftheart function in newborns. Systolic dysfunction was a hallmark of the cardiac adaptation in IUGR neonates.

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Fetal growth restriction: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Cited by 26 publications

References 68 publications

Long Non-coding RNA Gas5 Is Associated With Preeclampsia and Regulates Biological Behaviors of Trophoblast via MicroRNA-21

Long Non-coding RNA Gas5 Is Associated With Preeclampsia and Regulates Biological Behaviors of Trophoblast via MicroRNA-21

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

Cardiac left heart morphology and function in newborns with intrauterine growth restriction: relevance for long-term assessment

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