Cardiac left heart morphology and function in newborns with intrauterine growth restriction: relevance for long-term assessment

Zaharie, Gabriela; Hășmășanu, Monica; Blaga, Ligia; Matyas, Melinda; Mureşan, Daniel; Bolboacă, Sorana D.

doi:10.11152/mu-1667

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…We found shorter length of the left ventricle both in Early-FGR compared to Non-FGR and Early-FGR compared with Late-FGR, which is in accordance with other studies [14,31]. Several studies support our ndings that both term and premature FGR neonates had smaller diameter of the left ventricle [14,[31][32][33]. Most studies have examined mainly the left ventricle, while Patey et al [14] also studied the right ventricle in their term FGR group.…”

Section: Discussionsupporting

confidence: 91%

“…Cohen et al [35] found no difference in left ventricle wall thickness on day one when adjusting for body surface area, and Ciccone et al [37] found that the differences in diameter in interventricular septum and left ventricular posterior wall disappeared when normalized for body surface area in both term and premature Non-FGR neonates. Some studies report thinner ventricle septum in FGR [32,33], whereas others report opposite ndings [13,31]. Differences in study design and inclusion criteria might explain these differences.…”

Section: Discussionmentioning

confidence: 97%

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Cardiac morphology in neonates with fetal growth restriction

et al. 2022

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Objective: Assess effects of fetal growth restriction (FGR) on cardiac modelling in premature and term neonates.Study design: Prospective echocardiographic cohort study comparing FGR neonates (n=21) and controls (n=41) with normal prenatal growth and circulation.Results: Unadjusted for gestational age, birth weight, sex and twin/singleton, Late-FGR neonates had smaller hearts than controls, with globular left ventricles and symmetrical right ventricles. Adjusted estimates showed smaller left ventricles and similarly sized right ventricles, with symmetrical left and right ventricles. Early-FGR (compared with Late-FGR) had smaller hearts and globular left ventricles in unadjusted estimates, but after adjustment, sizes and shapes were similar.Conclusion: FGR had signi cant impact on cardiac modelling, both unadjusted and when adjusted for gestational age, birth weight, sex and twin/singleton. The adjustments, however, re ned the results notably and represents more speci c the effects of FGR, thus underscoring the importance of adjustments in such studies.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Cardiac morphology in neonates with fetal growth restriction

et al. 2022

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“…As expected, in those with cerebral haemorrhage, brain oxygenation was lower. Brain injury in premature infants appears as a complex association of primary diseases and secondary maturational and trophic disturbances, rather than as the result of a single agent [ 22 , 23 , 24 , 25 ]. Previously, relationships between the severity of GMHIVH or PVHI and cerebral oxygenation were found [ 22 , 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of the Cerebral Fractional Tissue Oxygen Extraction (cFTOE) and the Cerebral Oxygen Saturation (crSaO2) with Perinatal Factors in Preterm Neonates: A Single Centre Study

Matyas

Iancu

Hășmășanu

et al. 2022

JCM

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(1) Background: Near-infrared spectroscopy (NIRS) is a non-invasive, easily performed method of monitoring brain oxygenation. The regional cerebral oxygen saturation (crSaO2) and the cerebral fractional tissue oxygen extraction (cFTOE) evaluated by NIRS provide more accurate information on brain oxygenation than the blood oxygen saturation. We investigated the effect of perinatal factors on cerebral oxygenation of preterm newborns. (2) Methods: We conducted a longitudinal study with 48 preterm newborns <34 weeks of gestation who underwent NIRS registration during the first 72 h of life. crSaO2 was measured and cFTOE was calculated foreach patient. (3) Results: One-way ANOVA showed no significant main effect of IVH severity on crSaO2 and cFTOE (p > 0.05); there was a tendency toward statistical significance concerning the difference between the means of crSaO2 (p = 0.083) and cFTOE (p = 0.098). Patients with intraventricular haemorrhage (IVH) had a lower mean of crSaO2 and a higher mean of cFTOE (59.67 ± 10.37% vs. 64.92 ± 10.16% for crSaO2; 0.37 ± 0.11 vs. 0.32 ± 0.11 for cFTOE) compared to those with no IVH. Significantly lower values of crSaO2 and higher values of cFTOE were found in neonates receiving inotropic treatment (p < 0.0001). Episodes of apnoea also proved to influence the cerebral oxygen saturation of the study group (p = 0.0026). No significant association between the maternal hypertension treatment and the cerebral oxygenation of preterms was found. (4) Conclusions: This study showed a decreased cerebral oxygen saturation of preterms with IVH, inotrope support and apnoea episodes.

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“…While the use of 3D imaging and color Doppler in fetal cerebral and cardiac evaluation is already well established [ 9 ], a rather recent application in fetal ultrasound diagnosis brings promising new input for assessment of surgical approach in ovarian cysts larger than 5 cm [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Fetal Ovarian Cysts: Prenatal Diagnosis Using Ultrasound and MRI, Management and Postnatal Outcome—Our Centers Experience

et al. 2021

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The present study provides our clinical experience regarding the imaging diagnosis, management and postnatal outcome of neonates prenatally suspected of having developed ovarian cysts. This multicenter observational study included patients diagnosed prenatally with fetal ovarian cysts and follow-up in the postnatal period. Descriptive statistics were used to render the information regarding the prenatal imaging aspect of the fetal pelvic masses using ultrasound and/or MRI, prenatal surveillance and postnatal neonate’s immediate outcome, indications leading to surgery and pathologic aspect. The inclusion criteria were fulfilled by 21 patients. The mean gestational age at the time of initial diagnosis was 31.28 weeks of gestation (WG). Only five out of 21 cysts regressed completely during pregnancy without postnatal complications. In addition, 11 out of 21 infant’s required surgical treatment in the first two weeks after birth, mainly for ovarian torsion. Five out of 21 neonates were referred to postnatal follow-up clinically and by ultrasound, but three out of five cases required emergency surgical treatment for acute complications. Ultrasound plays a major role in the diagnostic of fetal ovarian cyst. From our experience, MRI does not bring supplementary data or change the management. Spontaneous resolution of fetal ovarian cysts is to be expected but the ovarian mass could lead to serious complications, if resolution does not occur in due time.

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Cardiac left heart morphology and function in newborns with intrauterine growth restriction: relevance for long-term assessment

Cited by 12 publications

References 32 publications

Cardiac morphology in neonates with fetal growth restriction

Cardiac morphology in neonates with fetal growth restriction

Association Analysis of the Cerebral Fractional Tissue Oxygen Extraction (cFTOE) and the Cerebral Oxygen Saturation (crSaO2) with Perinatal Factors in Preterm Neonates: A Single Centre Study

Fetal Ovarian Cysts: Prenatal Diagnosis Using Ultrasound and MRI, Management and Postnatal Outcome—Our Centers Experience

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