Fetal Growth and the Adrenocortical Response to Psychological Stress

Jones, Alexander; Godfrey, Keith M.; Wood, Peter; Osmond, Clive; Goulden, Peter; Phillips, David I. W.

doi:10.1210/jc.2005-2077

Cited by 159 publications

(116 citation statements)

References 12 publications

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“…This finding confirms the reliability of salivary cortisol measurements shown before in premature infants (15) and older children (16). We did not find the inverse relation between birth weight and cortisol levels as shown in other studies in children (7,17).…”

Section: Articles De Jong Et Alcontrasting

confidence: 53%

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

2015

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Section: Articles De Jong Et Alcontrasting

confidence: 53%

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

2015

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“…Although reports contradict and the direction of causality is unknown, the prevailing thought is that low birth weight predicts high cortisol output. 36,37 However, the discrepancy could be explained by the method used. High cortisol levels over longer periods of time differ from momentary cortisol concentrations or levels of response to specific stressors, as were used in earlier studies, maybe reflecting the continuous load of stress.…”

Section: Discussionmentioning

confidence: 99%

Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair

Karlén¹,

Frostell²,

Theodorsson³

et al. 2013

Pediatrics

119

112

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WHAT'S KNOWN ON THIS SUBJECT: Stress affects health of children, potentially persisting as a trajectory into adulthood. Earlier biological markers assess only momentary stress, making it difficult to investigate stress over longer periods of time. Cortisol in hair is a new biomarker of prolonged stress. WHAT THIS STUDY ADDS:Mother and child hair cortisol association suggests a heritable part or maternal calibration. Cortisol output gradually stabilizes, has a stable trait, and is positively correlated to birth weight. Hair cortisol is a promising noninvasive biomarker of prolonged stress, especially applicable for children. abstract OBJECTIVE: To investigate cortisol concentrations in hair as biomarker of prolonged stress in young children and their mothers and the relation to perinatal and sociodemographic factors.METHODS: Prospective cohort study of 100 All Babies In Southeast Sweden study participants with repeated measures at 1, 3, 5, and 8 years and their mothers during pregnancy. Prolonged stress levels were assessed through cortisol in hair. A questionnaire covered perinatal and sociodemographic factors during the child' s first year of life. RESULTS:Maternal hair cortisol during the second and third trimester and child hair cortisol at year 1 and 3 correlated. Child cortisol in hair levels decreased over time and correlated to each succeeding age, between years 1 and 3 (r = 0.30, P = .002), 3 and 5 (r = 0.39, P , .001), and 5 and 8 (r = 0.44, P , .001). Repeated measures gave a significant linear association over time (P , .001). There was an association between high levels of hair cortisol and birth weight (b = .224, P = .020), nonappropriate size for gestational age (b = .231, P = .017), and living in an apartment compared with a house (b = .200, P = .049). In addition, we found high levels of cortisol in hair related to other factors associated with psychosocial stress exposure. CONCLUSIONS:Correlation between hair cortisol levels in mothers and their children suggests a heritable trait or maternal calibration of the child' s hypothalamic-pituitary-adrenocortical axis. Cortisol output gradually stabilizes and seems to have a stable trait. Cortisol concentration in hair has the potential to become a biomarker of prolonged stress, especially applicable as a noninvasive method when studying how stress influences children' s health. Pediatrics 2013;132:e1333-e1340

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“…BuskeKirschbaum et al (2007) and Quesada et al (2014) also included moderately preterm children (gestational age between 32nd and 36th week) while the present study only included very preterm children. Though speculative, it is possible that there is a negative relationship between birth weight(/gestational age) and HPA axis activity above a certain level of birth weight(/gestational age) --as it was for instance found for boys with a birth weight between 2600g-4200g (Jones et al, 2006) --while this relationship becomes inverted below this level of birth weight(/gestational age), such that in children below a birth weight of around 2000g(/32nd gestational week) there is a positive relationship between birth weight(/gestational age) and HPA axis activity indicating down-regulation of the HPA axis with increasing degree of prematurity. As there were no children born moderately preterm in the current study we could not test this assumption.…”

Section: Differences In Salivary and Hair Glucocorticoids Between Vermentioning

confidence: 97%

Salivary and hair glucocorticoids and sleep in very preterm children during school age

Maurer

Perkinson-Gloor

Stalder

et al. 2016

Psychoneuroendocrinology

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Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30 min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall postawakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration.The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible downregulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.

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Fetal Growth and the Adrenocortical Response to Psychological Stress

Cited by 159 publications

References 12 publications

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair

Salivary and hair glucocorticoids and sleep in very preterm children during school age

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