Fetal fibronectin in the cervical secretion predicts accurately the onset of labor at term

Luton, Dominique; Gadrey, Jean; Sibony, Olivier; Braig, Suzanne; Benzakine, Y; Oury, Jean‐François; Porquet, Dominique; Blot, Philippe

doi:10.1016/s0301-2115(97)00109-7

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…The fFN predicts term labor within 2 to 7 days of sampling with a wide range of sensitivity, specificity, PPV, and NPV, 5,17,[37][38][39][40][41] while IL-1b predicts term labor within 7 days of sampling with 76% sensitivity, 55% specificity, 50% PPV, and 79% NPV. 17 Although the predictive properties of IL-1 and IL-1ra in this current study (either individually or in combination) cannot be directly compared with these previous fFN and IL-1b studies due to different sample-to-delivery time frames and study populations, we believe the combination of the 3 biomarkers (Il-1a, IL-1b, and IL-1ra) to predict spontaneous labor compares favorably to fFN with improved PPV.…”

Section: Discussionmentioning

confidence: 99%

The Interplay of the Interleukin 1 System in Pregnancy and Labor

et al. 2013

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This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the cervicovaginal fluid (CVF) beyond 24 weeks gestation including women in spontaneous term labor. Two cohorts of women were recruited at 24 to 35 weeks' gestation (n ¼ 65) and in late pregnancy (>36 weeks' gestation; n ¼ 88). The CVF was serially collected either every 4 weeks between 24 and 35 weeks' gestation (n ¼ 123 samples) or weekly during late pregnancy (n ¼ 240 samples). The IL-1 and IL-1ra were quantitated by enzyme-linked immunosorbent assay, and the effect of vaginal microflora and unprotected sexual intercourse were also investigated. The IL-1b and IL-1ra remain unaltered between 24 and 35 weeks' gestation. At late pregnancy, IL-1a and b concentrations peak at 4 to 14 days prior to labor onset, while IL-1ra decreases with approaching spontaneous term labor (P < .05, 2-way analysis of variance). The IL-1 and IL-1ra were significantly correlated (P < .001, Pearson r). A combined biomarker model of IL-1a, IL-1b, and IL-1ra can predict term labor with 86% sensitivity and 92% specificity. This study indicates a shifting inflammatory balance in the gestational tissues prior to labor onset.

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Section: Discussionmentioning

confidence: 99%

The Interplay of the Interleukin 1 System in Pregnancy and Labor

et al. 2013

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“…From five studies included, 480 patients could be extracted (6)(7)(8)(9)(10). All cases included were singleton term pregnancies ±37 gestational weeks of pregnancy.…”

Section: Predicting the Onset Of Term Labor And Deliverymentioning

confidence: 99%

Fetal fibronectin as a predictor of term labor: A literature review

Kiss

Ahner²,

Hohlagschwandtner³

et al. 2000

Acta Obstet Gynecol Scand

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“…Ahner et al [3] et Luton et al [20] obtiennent leurs résultats pour une prédiction de l'accouchement dans les 48 heures. Dans le groupe des patientes sélectionnées par Garite et al [5], deux tiers (108/160) avaient une FFN positive.…”

Section: Discussionunclassified