Fetal fibronectin as a predictor of term labor: A literature review

Kiss, Herbert; Ahner, Regine; Hohlagschwandtner, Maria; Leitich, Harald; Husslein, Peter

doi:10.1080/j.1600-0412.2000.079001003.x

Cited by 28 publications

(6 citation statements)

References 16 publications

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“…FFN may be released into cervicovaginal secretions through mechanical and infection‐mediated damage to the foetal membranes or placenta prior to birth . Elevated FFN levels in cervical fluids indicate an increased likelihood of delivery; thus, they are a predictor of term and preterm birth . Unlike in experimental animals such as sheep and small rodents, in human pregnancy blood levels of progesterone increase rather than decrease during labour.…”

Section: Introductionmentioning

confidence: 99%

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Expression of CPPED1 in human trophoblasts is associated with timing of term birth

Haapalainen

Karjalainen

Daddali

et al. 2017

J Cellular Molecular Medi

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Understanding of timing of human parturition is incomplete. Therefore, we carried out proteomic analyses of full‐term placentas from uncomplicated pregnancies to identify protein signatures associated with the onset of spontaneous delivery. We found quantitative associations of 10 proteins with spontaneous term birth, evident either in the basal or in the chorionic plates or in both. Additional 18 proteins were associated according to the location within placenta indicating local variations in protein amounts. Calcineurin‐like phosphoesterase domain‐containing 1 (CPPED1), a phosphatase previously suggested dephosphorylating AKT1/PKB, was one of the identified proteins. qRT‐PCR revealed the mRNA level of CPPED1 was higher in elective caesarean deliveries than in spontaneous births, while immunohistochemistry showed CPPED1 in cytotrophoblasts, syncytiotrophoblasts and extravillous trophoblasts. Noteworthy, phosphorylation status of AKT1 did not differ between placentas from elective caesarean and spontaneous deliveries. Additionally, analyses of samples from infants indicated that single‐nucleotide polymorphisms rs11643593 and rs8048866 of CPPED1 were associated with duration of term pregnancy. Finally, post‐transcriptional silencing of CPPED1 in cultured HTR8/SVneo cells by siRNAs affected gene expression in pathways associated with inflammation and blood vessel development. We postulate that functions regulated by CPPED1 in trophoblasts at choriodecidual interphase have a role in the induction of term labour, but it may be independent of AKT1.

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Section: Introductionmentioning

confidence: 99%

“…Several proteomic studies have reported biomarkers of term and preterm births . Over a hundred biomarkers of spontaneous preterm birth have been identified for various types of biochemical pathways .…”

Section: Introductionmentioning

confidence: 99%

Expression of CPPED1 in human trophoblasts is associated with timing of term birth

Haapalainen

Karjalainen

Daddali

et al. 2017

J Cellular Molecular Medi

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“…11 A review of eight reports concluded that a positive fFN was associated with significantly shorter delivery intervals than when a negative fFN result is obtained. 12 A positive fFN can aid management by predicting the onset of spontaneous labor within days, so that the patient can be counseled to wait. On the contrary, a negative fFN with a poor bishop's score can defer an induction in the absence of an emergent indication.…”

Section: Fetal Fibronectinmentioning

confidence: 99%

Induction of Labor

Dhawle¹

2012

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…Maternal immunomodulation in particular is vital to the tolerance of antigens of paternal origin [1][2][3][4]. Increased corticotrophin-releasing hormone in maternal plasma and secretion of fetal fibronectin into cervicovaginal fluids are indicators of delivery [5,6]. However, the timing of human labor, particularly the changes at the molecular level resulting in labor, are not currently understood.…”

Section: Introductionmentioning

confidence: 99%

CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery

et al. 2020

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MicroRNAs (miRNAs) are important regulators of gene expression, and their expression is associated with many physiological conditions. Here, we investigated potential associations between expression levels of miRNAs in human placenta and the onset of spontaneous term birth. Using RNA sequencing, we identified 54 miRNAs differentially expressed during spontaneous term labor compared to elective term births. Expression levels of 23 miRNAs were upregulated, whereas 31 were downregulated at least 1.5-fold. The upregulated miRNA miR-371a-5p putatively targets CPPED1, expression of which decreases during spontaneous birth. We used a luciferase reporter-based assay to test whether a miR-371a-5p mimic affected translation when it bound to the 3 0 untranslated region of CPPED1. In this setting, the miR-371a-5p mimic resulted in lower luciferase activity, which suggests that miR-371a-5p regulates levels of CPPED1. In conclusion, inversely correlated levels of miR-371a-5p and CPPED1 suggest a role for both in spontaneous delivery.

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Fetal fibronectin as a predictor of term labor: A literature review

Abstract: Determining the presence of FFN in cervicovaginal secretions promises to provide an indicator relating to the prediction of term labor, as well as to the prediction of successful labor induction.

Cited by 28 publications

References 16 publications

Expression of CPPED1 in human trophoblasts is associated with timing of term birth

Expression of CPPED1 in human trophoblasts is associated with timing of term birth

Induction of Labor

CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery

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