Fetal fat measurement by magnetic resonance imaging

Deans, Heather; Smith, Francis W.; Lloyd, Dorothy Jordan; Law, A.N.R.; Sutherland, H. W.

doi:10.1259/0007-1285-62-739-603

Cited by 33 publications

(18 citation statements)

References 8 publications

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“…Previous MRI studies by Deans et al (20) of fetal fat content at 40 wk gestation in utero have found similar body fat content to that in the present study (17.2%, cf. 16.6%) (20). However, the authors did not appear to differentiate between internal and subcutaneous AT.…”

Section: Discussionmentioning

confidence: 83%

“…Furthermore, whole-body MRI gives an unbiased measurement of the fat content, both internal and subcutaneous, for a large range of body shapes and sizes (19). To date there has been limited application of MRI to the study of AT content in neonates (20,21). Deans et al (20) measured body fat content of human fetuses in utero at 40 wk gestation and showed significant differences in fat content between infants from healthy women and those with gestational diabetes.…”

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confidence: 99%

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Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants

Harrington

Thomas²,

Modi

et al. 2002

Lipids

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The role of body fat content and distribution in infants is becoming an area of increasing interest, especially as perception of its function appears to be rapidly evolving. Although a number of methods are available to estimate body fat content in adults, many are of limited use in infants, especially in the context of regional distribution and internal depots. In this study we developed and implemented a whole-body magnetic resonance imaging (MRI)-based protocol that allows fast and reproducible measurements of adipose tissue content in newborn infants, with an intra-observer variability of <2.4% and an inter-observed variability of <7%. The percentage total body fat for this cohort of infants ranged from 13.3-22.6% (mean and standard deviation: 16.6 +/- 2.9%), which agrees closely with published data. Subcutaneous fat accounted for just over 89% of the total body fat, whereas internal fat corresponded to almost 11%, most of which was nonabdominal fat. There were no gender differences in total or regional body fat content. These results show that whole-body MRI can be readily applied to the study of adipose tissue content and distribution in newborn infants. Furthermore, its noninvasive nature makes it an ideal method for longitudinal and interventional studies in newborn infants.

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Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants

Harrington

Thomas²,

Modi

et al. 2002

Lipids

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“…It is possible that MRI will allow for a more reliable means of assessing amniotic fluid volume. Information regarding fetal fat (111), functional evaluation of the placenta (112,113), and placental volume assessments will likely be used in combination with other data to better distinguish between the constitutionally small but appropriately grown fetus and the fetus at risk due to placental insufficiency.…”

Section: Mr Volumetrymentioning

confidence: 99%

Obstetric MRI

Levine

2006

Magnetic Resonance Imaging

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Ultrasound is the imaging modality of choice for pregnant patients. However, MRI is increasingly utilized in patients in whom the sonographic diagnosis is unclear. These include maternal conditions unique to pregnancy such as ectopic pregnancy, placenta accreta, and uterine dehiscence. MRI is also being increasingly utilized in the assessment of abdominopelvic pain in pregnancy, in particular in assessment for appendicitis. Fetal MRI is performed to assess central nervous system (CNS) abnormalities and patients who are considering fetal surgery for conditions such as neural tube defects, congenital diaphragmatic hernia, and masses that obstruct the airway. In the future, functional MRI and fetal volumetry may provide additional information that can aid in our care of complicated pregnancies.

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“…30 Using imaging we could understand the origin of the significant relationship between visceral adipose tissue and adverse health and also explain the influence of ethnic and gender differences in adipose tissue distribution. 18 MRI for pediatric body composition measurement is relatively new and the lack of radiation exposure associated with its use makes it more applicable than CT. On the other hand, MRI is to our knowledge the only method in vivo used to study fetal body composition 31 and it could help to understand the physiological and pathological condition in the newborn. The reproducibility of MRI for subcutaneous adipose tissue in the infant is between 2.4 and 4.0% and approximately 17% for visceral adipose tissue.…”

Section: Imagingmentioning

confidence: 99%

Adipose tissue and metabolic effects: new insight into measurements

2005

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BACKGROUND: Epidemiologic evidence supports the theory that the relation between obesity and disease risk begins early in life, and those risk factors for disease track, or remain at a similar level, with advancing age, growth, and development. The fat tissue, once considered as a depot for energy substrate, is a metabolically active tissue. The fat cells produce agents that regulate a host of physiological processes directly related to carbohydrate and fat metabolism and the development of cardiovascular disease and type 2 diabetes. AIM: To discuss fat tissue, and fat distribution in relation to body composition measurements, with particular emphasis on imaging techniques (ie, dual energy X-ray absorptiometry (DXA), computed tomography (CT), and magnetic resonance imaging (MRI)) and its relationship with metabolic and cardiovascular heath variables mediated by the metabolic characteristics of the adipose tissue. DISCUSSION: In sum, the medical and physiological health complications of childhood obesity are well documented. Imaging methods are considered the most accurate means available for in vivo quantification at the tissue-organ level and the methods of choice for calibration of field methods designed to measure adipose tissue.

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Fetal fat measurement by magnetic resonance imaging

Cited by 33 publications

References 8 publications

Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants

Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants

Obstetric MRI

Adipose tissue and metabolic effects: new insight into measurements

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