Fetal exposure to aflatoxins in the United Arab Emirates

Abdulrazzaq, Yousef M.; Osman, Nawal; Aliyu, Ibrahim

doi:10.1179/027249302125000094

Cited by 79 publications

(56 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies in the Gambia and Kenya found significant association between aflatoxin exposure and wasting (Okoth and Ohingo 2004). Four studies (Abdulrazzaq et al 2002;Abdulrazzaq et al 2004;Abulu et al 1998;Turner et al 2007) reported a negative correlation between birth weight and aflatoxin levels; two studies found this relationship only when the sex of the infant was female (Jonsyn et al 1995a;Vries et al 1989).…”

Section: Cgiar Agricultural Research On Food Safety and Aflatoxinsmentioning

confidence: 95%

International agricultural research to reduce food risks: case studies on aflatoxins

et al. 2015

View full text Add to dashboard Cite

Despite massive expansion of human and livestock populations, fuelled by agricultural innovations, nearly one billion people are hungry and 2 billion are sickened each year from the food they eat. Agricultural and food systems are intimately connected to health outcomes, but health policy and programs often stop at the clinic door. A consensus is growing that the disconnection between agriculture, health and nutrition is at least partly responsible for the disease burden associated with food and farming. Mycotoxins produced by fungi are one of the most serious food safety problems affecting staple crops (especially maize and groundnuts).Aflatoxins, the best studied of these mycotoxins, cause around 90,000 cases of liver cancer each year and are strongly associated with stunting and immune suppression in children. Mycotoxins also cause major economic disruptions through their impacts on trade and livestock production. In this paper we use the case of fungal toxins to explore how agricultural research can produce innovations, understand incentives and enable institutions to improve, simultaneously, food safety, food accessibility for poor consumers and access to markets for smallholder farmers, thus making the case for research investors to support research into agricultural approaches for enhancing food safety in value chains. We first discuss the evolution of food safety research within the CGIAR. Then we show how taking an epidemiological and economic perspective on aflatoxin research connects health and nutrition outcomes. Finally, we present three case studies illustrating the traditional strengths of CGIAR research: breeding better varieties and developing new technologies.

show abstract

Section: Cgiar Agricultural Research On Food Safety and Aflatoxinsmentioning

confidence: 95%

International agricultural research to reduce food risks: case studies on aflatoxins

et al. 2015

View full text Add to dashboard Cite

show abstract

“…1 Dietary exposure to aflatoxins has liver by microsomal oxidase to reactive AFB 1 (8,9-epoxide) that is covalently linked to DNA, inducing mutation of the p53 gene at codon 249 (p53 mt 249), a critical factor in the development of hepatocarcinoma. [5][6][7][8] Aflatoxins also cross the placenta and high concentrations have been found in cord blood, 3,9 thereby affecting the fetus and newborn. It has been reported to be a risk factor for jaundice in the newborn.…”

Section: Introductionmentioning

confidence: 99%

Morbidity in neonates of mothers who have ingested aflatoxins

Abdulrazzaq

Osman

Yousif

et al. 2004

Annals of Tropical Paediatrics

Self Cite

View full text Add to dashboard Cite

This study was undertaken to assess whether aflatoxin M(1) concentrations in newborn infants correlated with those of their mothers and to determine whether the presence of aflatoxin M(1) in cord blood was associated with an increase in morbidity in the newborn. There was a strong correlation (r =0.797, p <0.0001) between mothers' and cord blood levels of aflatoxin. There was also a strong negative correlation between aflatoxin levels and birthweight (r =-0.565, p <0.001) but there was no association between aflatoxin M(1) concentration in maternal or cord blood and rates of jaundice or infection.

show abstract

“…The presence of aflatoxin resulted in lower birth weights. The high rate of detection of aflatoxins confirms that a significant number of infants are exposed to these toxins which reflects maternal ingestion of aflatoxin-containing food (Abdulrazzaq, Osman, & Ibrahim, 2002). The association between low birth weight and the diseases in the adult life is a point threatening the infant and child health (Donma & Donma, 2003a).…”

Section: Phytoestrogensmentioning

confidence: 94%