Morbidity in neonates of mothers who have ingested aflatoxins

Abdulrazzaq, Yousef M.; Osman, Nawal; Yousif, Zuheir M.; Trad, Omar

doi:10.1179/027249304225013420

Cited by 65 publications

(46 citation statements)

References 34 publications

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“…Regarding the relation between aflatoxin B1 level in studied children and their mothers, a significant positive correlation was demonstrated between them which might be explained by exposure to maternal aflatoxin during fetal life as supported by the findings of Abdulrazzaq et al [22] who found a strong correlation (p <0.0001) between mothers' and cord blood levels of aflatoxin. Another possibility is that these children share the same type of foods with their mothers which might be the source of aflatoxin for both of them.…”

Section: Discussionsupporting

confidence: 78%

Aflatoxin B1 Level in Relation to Child’s Feeding and Growth

et al. 2011

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Section: Discussionsupporting

confidence: 78%

Aflatoxin B1 Level in Relation to Child’s Feeding and Growth

et al. 2011

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“…The aflatoxin -albumin adduct level of the infant at 16 weeks significantly negatively correlated (P, 0·05) with infant growth (52) . These studies are further supported by data in additional epidemiological studies (117,118) .…”

Section: Aflatoxin Biomarker Levels Are Associated With Growth Falteringsupporting

confidence: 73%

The role of biomarkers in evaluating human health concerns from fungal contaminants in food

et al. 2012

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Mycotoxins are toxic secondary metabolites that globally contaminate an estimated 25 % of cereal crops and thus exposure is frequent in many populations. Aflatoxins, fumonisins and deoxynivalenol are amongst those mycotoxins of particular concern from a human health perspective. A number of risks to health are suggested including cancer, growth faltering, immune suppression and neural tube defects; though only the demonstrated role for aflatoxin in the aetiology of liver cancer is widely recognised. The heterogeneous distribution of mycotoxins in food restricts the usefulness of food sampling and intake estimates; instead biomarkers provide better tools for informing epidemiological investigations. Validated exposure biomarkers for aflatoxin (urinary aflatoxin M 1 , aflatoxin -N7-guaunine, serum aflatoxin -albumin) were established almost 20 years ago and were critical in confirming aflatoxins as potent liver carcinogens. Validation has included demonstration of assay robustness, intake v. biomarker level, and stability of stored samples. More recently, aflatoxin exposure biomarkers are revealing concerns of growth faltering and immune suppression; importantly, they are being used to assess the effectiveness of intervention strategies. For fumonisins and deoxynivalenol these steps of development and validation have significantly advanced in recent years. Such biomarkers should better inform epidemiological studies and thus improve our understanding of their potential risk to human health.

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“…Other studies show associations between aflatoxins and stillbirths (Lamplugh et al 1988;Vries et al 1989), liver cirrhosis (Kuniholm et al 2008), jaundice in newborns (Abdulrazzaq et al 2004;Abulu et al 1998;Ahmed et al 1995;Sodeinde et al 1995) and immunosuppression (Jiang et al 2005;Turner et al 2003).…”

Section: Cgiar Agricultural Research On Food Safety and Aflatoxinsmentioning

confidence: 94%

“…Other studies in the Gambia and Kenya found significant association between aflatoxin exposure and wasting (Okoth and Ohingo 2004). Four studies (Abdulrazzaq et al 2002;Abdulrazzaq et al 2004;Abulu et al 1998;Turner et al 2007) reported a negative correlation between birth weight and aflatoxin levels; two studies found this relationship only when the sex of the infant was female (Jonsyn et al 1995a;Vries et al 1989).…”

Section: Cgiar Agricultural Research On Food Safety and Aflatoxinsmentioning

confidence: 95%

International agricultural research to reduce food risks: case studies on aflatoxins

et al. 2015

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Despite massive expansion of human and livestock populations, fuelled by agricultural innovations, nearly one billion people are hungry and 2 billion are sickened each year from the food they eat. Agricultural and food systems are intimately connected to health outcomes, but health policy and programs often stop at the clinic door. A consensus is growing that the disconnection between agriculture, health and nutrition is at least partly responsible for the disease burden associated with food and farming. Mycotoxins produced by fungi are one of the most serious food safety problems affecting staple crops (especially maize and groundnuts).Aflatoxins, the best studied of these mycotoxins, cause around 90,000 cases of liver cancer each year and are strongly associated with stunting and immune suppression in children. Mycotoxins also cause major economic disruptions through their impacts on trade and livestock production. In this paper we use the case of fungal toxins to explore how agricultural research can produce innovations, understand incentives and enable institutions to improve, simultaneously, food safety, food accessibility for poor consumers and access to markets for smallholder farmers, thus making the case for research investors to support research into agricultural approaches for enhancing food safety in value chains. We first discuss the evolution of food safety research within the CGIAR. Then we show how taking an epidemiological and economic perspective on aflatoxin research connects health and nutrition outcomes. Finally, we present three case studies illustrating the traditional strengths of CGIAR research: breeding better varieties and developing new technologies.

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Morbidity in neonates of mothers who have ingested aflatoxins

Cited by 65 publications

References 34 publications

Aflatoxin B1 Level in Relation to Child’s Feeding and Growth

Aflatoxin B1 Level in Relation to Child’s Feeding and Growth

The role of biomarkers in evaluating human health concerns from fungal contaminants in food

International agricultural research to reduce food risks: case studies on aflatoxins

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