2011
DOI: 10.3109/14767058.2011.556204
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Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia

Abstract: High circulating levels of maternal endothelial dysfunction markers present in pre-eclampsia are associated with decreased NO synthesis in fetal endothelium.

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Cited by 40 publications
(40 citation statements)
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“…In agreement with previous results [47], we found a correlative relationship between NO availability and proliferation in HUVECs in both LOPE and EOPE. This evidence agrees with previous reports where A 2A AR triggers an intracellular pathway dependent on NO synthesis [23,41].…”
Section: Discussionsupporting
confidence: 82%
“…In agreement with previous results [47], we found a correlative relationship between NO availability and proliferation in HUVECs in both LOPE and EOPE. This evidence agrees with previous reports where A 2A AR triggers an intracellular pathway dependent on NO synthesis [23,41].…”
Section: Discussionsupporting
confidence: 82%
“…Levels of SE-selectin were negatively associated with newborn weight. High circulating levels of maternal endothelial dysfunction markers such as E-selectin present in PE are associated with decreased nitric oxide (NO) synthesis in fetal endothelium and high risk for preterm delivery and very preterm delivery or fetal extremely low birth weight compared with women with low levels (19). Although, Chen study didn't show association between high serum sE-selectin and risk of preterm delivery.…”
Section: J Biol Today's World 2018 Jan; 7 (1): 16-19contrasting
confidence: 47%
“…Today's World. 2018 Jan; 7 (1): [16][17][18][19] lower in case group (P=0.001). Serum concentration of Eselectin was significantly higher in PE compared to normal pregnant women (78.…”
Section: Resultsmentioning
confidence: 99%
“…The diagnostic sensitivity and specificity in differentiating preeclampsia from gestational and chronic hypertension were 84% and 95%, respectively, for sFlt-1 (59 ). Clinically, sFlt-1 concentrations have been observed to be directly proportional to severity of proteinuria, but inversely correlated with platelet count, gestational age, and neonatal birth weight adjusted for gestational age (60,61 ). In women with preeclampsia, concentrations of sFlt-1 are higher in those with early onset (Ͻ37 weeks), more severe disease (14,28,30,62 ), and SGA (small for gestational age) neonates (28,30,60 ).…”
Section: Angiogenic Factors In the Diagnosis Of Preeclampsiamentioning
confidence: 99%