Fetal effects of cadmium in pregnant rats on normal and zinc deficient diets

Parzyck, Dennis Cos; Shaw, Stanley M.; Kessler, Wayne V.; Vetter, Richard J.; Sickle, David C. Van; Mayes, Roger A.

doi:10.1007/bf01685788

Cited by 33 publications

(2 citation statements)

References 9 publications

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“…Furthermore, the persistence of lead and other metals in pregnant and breast feeding mothers, and their toxic effects on various developing organs have increased the concerns of their safeties in public health. Moreso, metal-induced toxicity in pregnant animals is related to the age of pregnancy, animal species, as well as the amount of exposure (Parzyck et al, 1978;Andrews et al, 1994;Bellinger, 2005;Karri et al, 2008;Thompson and Bannigan, 2008). Thus, data on the impact of maternal Pb toxicity in relation to dose, age of pregnancy, and duration of exposure are of special concerns.…”

Section: +mentioning

confidence: 99%

Maternal lead exposure and pregnancy outcome in Wistar albino rats

Aprioku¹

2013

J. Toxicol. Environ. Health Sci.

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Lead (Pb) is a heavy metal environmental pollutant and toxicant. The present study investigated doserelated effects of maternal Pb exposure on pregnancy outcome. Wistar albino rats were gavaged with Pb nitrate (4 or 8 mg/kg) or vehicle daily from gestation day 0 until delivery. Length of pregnancy was noted. Number, birth weight and physical characteristics of pups were registered. Neonatal mortality was also recorded between days 1 to 15 post-delivery. Lead treatment significantly (p < 0.05) inhibited maternal body weight gain and caused abortion of pregnancy dose-dependently (4 mg/kg: 67.7%, 8 mg/kg: 100%). Besides, all occurring births in 4 mg/kg Pb-exposed rats were preterm (p = 0.0023) with morphological abnormalities in the head and limbs, and about 33% were still births. Also, average number and birth weight of Pb-exposed rats offspring were significantly (p < 0.0001) lower compared to controls. Furthermore, while body weights of offspring of control rats increased significantly (p < 0.0001) over time, those of Pb-exposed rats decreased significantly (p = 0.0077). Neonatal survival was 0% in Pb treated rats and 100% in control. The results demonstrate that maternal Pb exposure adversely and dose-dependently affects pregnancy outcome.

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Section: +mentioning

confidence: 99%

Maternal lead exposure and pregnancy outcome in Wistar albino rats

Aprioku¹

2013

J. Toxicol. Environ. Health Sci.

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“…Oral administration caused some anomalies of the genito-urinary tract and of the heart (Nolen et Scharpf et al, 1972), but was much less toxic than injection, since more than half of the fetuses survived an oral administration by intubation of 80 mg/ kg/ day from days 6 to 19 of pregnancy. Intravenous or intraperitoneal injection of 1-2 mg/kg to rats on days 9-11 elicited hydrocephaly, microphthalmy and anophthalmy (Barr, 1973;Samarawickrama and Webb, 1979), except in the Holtzman strain, where only stunting of the head region was observed (Parzyk et al, 1978). Abnormalities, such as micrognathy or small lung size, were most frequent after s.c. injection of 12 mg on day 14 or IS (Chernoff, 1973), but it should be recalled in this context that at this time of gestation, the placenta is barely permeable to cadmium, and that some effects may also result from an impaired supply of nutrients due to cadmium-induced damage of the placenta (Chiquoine, 1965;Parizek, 1963).…”

Section: Teratogenesismentioning

confidence: 99%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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Teratogenicity, fetal toxicity and tissue concentration of cadmium administered to female rats during organogenesis

Barański

Stetkiewicz

Trzcinka-Ochocka

et al. 1982

J of Applied Toxicology

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Cadmium chloride was administered by gavage to pregnant rats from day 7 to day 16 of gestation. Cadmium, when administered at a dose of 40 mg Cd per kg per day, was associated with significant maternal toxicity, placental injury and an increased fetal burden of cadmium. At lower dose levels (2-20 mg Cd per kg per day), fetal development was retarded. Teratogenic effects were not observed and the fetal cadmium concentrations did not differ significantly from the controls, despite the marked cadmium accumulation in the placenta and maternal tissues. The body-weight gain during gestation of all cadmium-treated females was reduced and an absolute weight of adrenals in females given cadmium at doses 4 mg kg-1 and higher was significantly increased. The obtained results indicate that cadmium-induced fetal toxicity is associated with concomitant maternal toxicity and alteration in placental function.

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Fetal effects of cadmium in pregnant rats on normal and zinc deficient diets

Cited by 33 publications

References 9 publications

Maternal lead exposure and pregnancy outcome in Wistar albino rats

Maternal lead exposure and pregnancy outcome in Wistar albino rats

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Teratogenicity, fetal toxicity and tissue concentration of cadmium administered to female rats during organogenesis

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