Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders, Micheline

doi:10.1007/978-1-4613-2643-4

Cited by 7 publications

References 492 publications

(663 reference statements)

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Basic Elements of Toxicology

Ballantyne¹,

Marrs

Syversen

2009

General, Applied and Systems Toxicology

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Toxicology is a multidisciplinary science concerned with determining the potential of chemicals and certain physical agents, such as ionizing radiation, to produced adverse effects in living organisms. Adverse effects in the context of this definition are those that are detrimental to the normal functioning or survival of the organism. If such effects occur, it is necessary to know their nature, incidence, mechanism of production, factors influencing their development and reversibility. This overview chapter discusses the following major elements in the science of toxicology: historical aspects; definitions and scope; subdisciplines; routes of exposure; dosage‐response relationships; factors influencing toxicity; biohandling of xenobiotics; toxicity of mixtures; conduct and review of toxicology studies; hazard evaluation and risk assessment; professional and ethical issues.

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Basic Elements of Toxicology

Ballantyne¹,

Marrs

Syversen

2009

General, Applied and Systems Toxicology

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3‐Hydroxypropylmercapturic acid: A biologic marker of exposure to allylic and related compounds

Sanduja

Ansari

Boor

1989

J of Applied Toxicology

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3-Hydroxypropylmercapturic acid [3-OHPrMCA, S-(3-hydroxypropyl)-N-acetyl-L-cysteine] was quantitatively measured by high-performance liquid chromatography (HPLC) in the urine of rats given allylamine.HCl (5, 25, 50, 100 and 150 mg kg-1), acrolein (13 mg kg-1), allylalcohol (64 mg kg-1), allylchloride (76 mg kg-1), allylbromide (120 mg kg-1), allylcyanide (115 mg) and cyclophosphamide (160 mg kg-1) by gavage in water. 3-OHPrMCA was measured by HPLC in 24-h urine collections; the lower detection limit was 1.25 micrograms or 5.6 nmol ml-1. Various doses of allylamine resulted in 3-OHPrMCA excretion at a fairly constant percentage of the dose, ca. 44-48% at 0-24 h and 3% at 24-48 h, indicating rapid metabolism through glutathione conjugation in the first 24h. Similarly, 3-OHPrMCA was recovered in the urine of rats given acrolein (78.5%), allylalcohol (28.3%), allylchloride (21.5%), allylbromide (3.0%), allylcyanide (3.7%) and cyclophosphamide (2.6%). These data indicate that 3-OHPrMCA can be used as a marker of exposure to allylic and other compounds that lead to the metabolic formation of acrolein.

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Literature-derived absorption coefficients for 39 chemicals via oral and inhalation routes of exposure

Owen

1990

Regulatory Toxicology and Pharmacology

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Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Cited by 7 publications

References 492 publications

Basic Elements of Toxicology

Basic Elements of Toxicology

3‐Hydroxypropylmercapturic acid: A biologic marker of exposure to allylic and related compounds

Literature-derived absorption coefficients for 39 chemicals via oral and inhalation routes of exposure

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