Fetal development of regulatory mechanisms for body fluid homeostasis

Guan, Jun; Mao, Caiping; Feng, Xin; Zhang, Hao; Xu, Fulin; Geng, C.; Zhu, Liyan; Wang, A.; Xu, Zhice

doi:10.1590/s0100-879x2008005000025

Cited by 14 publications

(10 citation statements)

References 55 publications

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“…In regard to the salivary glands, Fanni et al [28] indicated that thymosin â10 has a role in their organogenesis. Based on the established data about ANP role in rat brain development [15,16,22], our results showing ANP presence early during the development of human parotid gland suggest that ANP might be involved in parotid gland's maturation similarly as in the nervous system.…”

Section: Discussionmentioning

confidence: 55%

See 1 more Smart Citation

Atrial Natriuretic Peptide presence in parotid gland of human fetus at 13th week of development and in adult man

Lipari

Farina

Buscemi

et al. 2013

Folia Histochem Cytobiol.

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Our immunohistochemical study shows that atrial natriuretic peptide (ANP) is present in both human fetal and adult parotid gland. In the fetuses ANP is localized in cell clusters, while in adult parotid gland, the ANP is seen only in the wall of intra-and extralobular ducts. The results suggest that ANP might play a role in the differentiation of the parotid gland similarly as in brain and that during fetal growth ANP may play a role in the regulating the secretion of primitive salivary fluid, even if acini are still not developed.

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Section: Discussionmentioning

confidence: 55%

“…The literature data on the ANP-ontogeny refer to heart [13][14][15], brain [16][17][18], and lung [19]. The morphology of developing salivary glands was described in rat [20,21], mouse [22], miniature pig [23], and in humans [24].…”

Section: Introductionmentioning

confidence: 99%

Atrial Natriuretic Peptide presence in parotid gland of human fetus at 13th week of development and in adult man

Lipari

Farina

Buscemi

et al. 2013

Folia Histochem Cytobiol.

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“…It was noted that maternal water deprivation significantly reduced fetal urine volume associated with an increase of urine osmolality at near‐term. One of the mechanisms behind this phenomenon could be aldosterone that is critical in regulation of fetal renal excretion (Guan et al, 2008; Mann et al, 1999). Notably, fetal plasma aldosterone was significantly increased following exposure to maternal water deprivation in the present study.…”

Section: Discussionmentioning

confidence: 99%

Ovine fetal hormonal and hypothalamic neuroendocrine responses to maternal water deprivation at late gestation

Zhu

Mao²,

Wu³

et al. 2009

Intl J of Devlp Neuroscience

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Angiotensin II (Ang II), aldosterone, and arginine-vasopressin (AVP) are three major neuropeptides or hormones that are important in the control of body fluid regulation. Dehydration during pregnancy induces alterations in maternal-fetal fluid homeostasis. It is still not clear about effects and mechanisms of maternal water deprivation on fetal neuroendocrine and hormonal responses. The present study deprived water from pregnant sheep at near-term for 24 h and 48 h, and determined maternal and fetal blood osmolality and sodium levels before and immediately after water deprivation. Fetal renal excretion and plasma hormones were measured. Fetal forebrain was analyzed for cellular activation marked with Fos and Fos-B. The results showed that maternal and fetal blood osmolality and sodium were increased by water deprivation. Maternal and fetal Ang II, aldosterone, and AVP levels were elevated by 24-h and 48-h water deprivation, while fetal plasma Ang I levels were increased only under the condition of 48-h water deprivation. Intensive Fos and Fos-B expression was detected in the median preoptic nuclei and paraventricular nuclei in the fetal brain following exposure to maternal water deprivation. Double labeling demonstrated that many Fos-positive cells were AVP-containing neurons in the fetal paraventricular nucleus. Together, the results suggest that neuroendocrine and hormonal regulatory mechanisms play a role in the control of body fluid homeostasis, and relatively matured and functional at the last third of gestation, as well as the fetal hypothalamus is functional in the control of the neuropeptide in response to maternal dehydration.

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“…They also concluded that no fetal organ controls the fetal fl uid volume, and the main determinants in fl uid balance are cardiac, circulatory, renal, and placental properties [ 28 ].…”

Section: Fetal Fluid Dynamicsmentioning

confidence: 99%

Fetal Hydrops

Nagy¹,

Malcomson²

2015

Keeling’s Fetal and Neonatal Pathology

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Hydrops fetalis, meaning "edema of the fetus," is a clinicopathological term describing an end-stage status of fetal fl uid imbalance, and the diagnostic criteria include generalized skin edema with one or more serous cavity effusions. The underlying causes include various maternal, fetal, and placental conditions. Even if the underlying forces to edema formation are the same as has been described in adults (Starling forces), the unique features of fetal physiology, including characteristics of fetal microcirculation and immaturity of the developing organs, predispose to fetal edema formation. This chapter aims to provide some insight into the underlying pathophysiological mechanisms and should help to rationalize and categories the myriad conditions that may give rise to fetal hydrops. A better understanding of the various processes at work in the generation of hydrops provides more information for parental counseling and for more targeted antepartum/perinatal treatments. The importance of postmortem examination, including ancillary investigations, cannot be emphasized enough. Recent publications highlight the usefulness of immunohistochemical assessment of lymphatic vessels in idiopathic cases. It has been also shown that, when postmortem examinations are completed along with clinical assessments, the underlying causes can be found in very high percentage of the cases (>90 %). Even if the underlying forces to edema formation are the same as has been described in adults (Starling forces), the unique features of fetal physiology, including characteristics of fetal microcirculation and immaturity of the developing organs, predispose to fetal edema formation. This chapter aims to provide some insight into the underlying pathophysiological mechanisms and should help to rationalize and categories the myriad conditions that may give rise to fetal hydrops. A better understanding of the various processes at work in the generation of hydrops provides more information

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Fetal development of regulatory mechanisms for body fluid homeostasis

Cited by 14 publications

References 55 publications

Atrial Natriuretic Peptide presence in parotid gland of human fetus at 13th week of development and in adult man

Atrial Natriuretic Peptide presence in parotid gland of human fetus at 13th week of development and in adult man

Ovine fetal hormonal and hypothalamic neuroendocrine responses to maternal water deprivation at late gestation

Fetal Hydrops

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