Fetal death as a result of placental immune reconstitution inflammatory syndrome

Caby, Fabienne; Lemercier, Delphine; Coulomb, Aurore; Grigorescu, R; Paris, Luc; Touafek, Fériel; Carcelain, Guislaine; Canestri, Ana; Pauchard, Michèle; Katlama, Christine; Dommergues, Marc; Tubiana, Roland

doi:10.1016/j.jinf.2010.03.026

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…Normal placental development is required for embryonic growth, and placental dysfunction has been associated with miscarriage and fetal growth restriction 23. To determine the effects of intrauterine inflammation, we compared the fetal and placental weights of intrauterine inflammatory mice with control mice.…”

Section: Resultsmentioning

confidence: 99%

Intrauterine Inflammation Increases Materno‐Fetal Transfer of Gold Nanoparticles in a Size‐Dependent Manner in Murine Pregnancy

Tian

Zhu

et al. 2013

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The materno-fetal transfer of nanoparticles is a critical issue in designing theranoustic nanoparticles for in vivo applications during pregnancy. Recent studies have reported that certain nanoparticles can cross the placental barrier in healthy pregnant animals depending on the size and surface modification of the nanoparticles and the developmental stages of the fetuses. However, materno-fetal transfer under pathological pregnant conditions has not been examined so far. Here, it is shown that intrauterine inflammation can enhance the materno-fetal transfer of nanoparticles in the late gestation stage of murine pregnancy in a size-dependent manner. Three different-sized gold nanoparticles (Au NPs) with diameters of 3 (Au3), 13 (Au13) and 32 (Au32) nm are applied. The accumulation of Au3 and Au13 nanoparticles in the fetuses is significantly increased in intrauterine inflammatory mice compared with healthy control mice: the concentration of Au3 is much higher than Au13 in fetal tissues of intrauterine inflammatory mice. In contrast, Au32 nanoparticles cannot cross the placental barrier either in healthy or in intrauterine inflammatory mice. The possible underlying mechanism of the increased materno-fetal transfer of small-sized nanoparticles on pathological conditions is inferred to be the structural and functional abnormalities of the placenta under intrauterine inflammation. The size of the nanoparticles is one of the critical factors which determines the extent of fetal exposure to nanoparticles in murine pregnancy under inflammatory conditions.

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Section: Resultsmentioning

confidence: 99%

Intrauterine Inflammation Increases Materno‐Fetal Transfer of Gold Nanoparticles in a Size‐Dependent Manner in Murine Pregnancy

Tian

Zhu

et al. 2013

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“…So far, more than 20 cases of IRIS-associated CT have been reported in the literature (Table 2). A low CD4 cell count has been identified as a significant risk factor in AIDS patients with CT (Tsambiras et al, 2001;de Boer et al, 2003;Sendi et al, 2006;Chen et al, 2009;Caby et al, 2010;Kung et al, 2011) due to impaired proliferative response to Toxoplasma antigen (Belanger et al, 1999), a decreased production of interferon  (Ullum et al, 1997), and it is found to be more common that IRIS develops in HIV-infected patients (Jevtović et al, 2005). Therefore, monitoring of CD4/CD8 T cells in patients on HAART might serve as a better marker for the restoration of T. gondii-specific immune responses than the total number of CD4 cells count (Furco et al, 2008).…”

Section: Immune Reconstitution Inflammatory Syndrome (Iris) -From Pasmentioning

confidence: 99%

Toxoplasmosis in HIV/AIDS Patients - A Living Legacy

Nissapatorn¹

2011

Microbes, Viruses and Parasites in AIDS Process

101

124

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“…So far, more than 20 cases of CT associated IRIS have been reported in the literature (Table). A low CD4 + cell count has been identified as a significant risk factor in AIDS patients with CT93130–134 due to impaired proliferative response to Toxoplasma antigen135, a decreased production of interferon γ136, and IRIS develops more commonly in HIV-infected patients137. Therefore, monitoring of CD4 + /CD8 + T cells in patients on HAART might serve as a better marker for the restoration of T. gondii -specific immune responses than the total number of CD4 + cells count138.…”

Section: Immune Reconstitution Inflammatory Syndrome (Iris) Associatementioning

confidence: 99%

Parasitic infections in HIV infected individuals: Diagnostic & therapeutic challenges

Nissapatorn¹,

Sawangjaroen²

2011

Indian J Med Res

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After 30 years of the human immunodeficiency virus (HIV) epidemic, parasites have been one of the most common opportunistic infections (OIs) and one of the most frequent causes of morbidity and mortality associated with HIV-infected patients. Due to severe immunosuppression, enteric parasitic pathogens in general are emerging and are OIs capable of causing diarrhoeal disease associated with HIV. Of these, Cryptosporidium parvum and Isospora belli are the two most common intestinal protozoan parasites and pose a public health problem in acquired immunodeficiency syndrome (AIDS) patients. These are the only two enteric protozoan parasites that remain in the case definition of AIDS till today. Leismaniasis, strongyloidiasis and toxoplasmosis are the three main opportunistic causes of systemic involvements reported in HIV-infected patients. Of these, toxoplasmosis is the most important parasitic infection associated with the central nervous system. Due to its complexity in nature, toxoplasmosis is the only parasitic disease capable of not only causing focal but also disseminated forms and it has been included in AIDS-defining illnesses (ADI) ever since. With the introduction of highly active anti-retroviral therapy (HAART), cryptosporidiosis, leishmaniasis, schistosomiasis, strongyloidiasis, and toxoplasmosis are among parasitic diseases reported in association with immune reconstitution inflammatory syndrome (IRIS). This review addresses various aspects of parasitic infections in term of clinical, diagnostic and therapeutic challenges associated with HIV-infection.

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Fetal death as a result of placental immune reconstitution inflammatory syndrome

Cited by 13 publications

References 21 publications

Intrauterine Inflammation Increases Materno‐Fetal Transfer of Gold Nanoparticles in a Size‐Dependent Manner in Murine Pregnancy

Intrauterine Inflammation Increases Materno‐Fetal Transfer of Gold Nanoparticles in a Size‐Dependent Manner in Murine Pregnancy

Toxoplasmosis in HIV/AIDS Patients - A Living Legacy

Parasitic infections in HIV infected individuals: Diagnostic & therapeutic challenges

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