Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction

Dizon‐Townson, Donna; Meline, L; Nelson, Lesa; Varner, Michael W.; Ward, Kenneth

doi:10.1016/s0002-9378(97)70205-9

Cited by 238 publications

(120 citation statements)

References 15 publications

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“…In a case control study limited to first trimester losses only, Balasch et al (1997) could not demonstrate any clear association with hereditary APCR. This finding was echoed by Dizon-Townson et al (1997), who did not find hereditary APCR in any of the participating women with idiopathic recurrent miscarriage. Preston et al (1996), in a retrospective study, could not elicit a link between hereditary APCR and first and second-trimester losses either.…”

Section: Hereditary Apcr (Factor V Leiden) and Pregnancy Lossmentioning

confidence: 89%

“…In pregnancy the pre-existence of a thrombophilic disorder may exaggerate the physiologically induced state of hypercoagulation and therefore potentiate the thrombotic risk. It has been hypothesised that thrombophilia may be associated with serious obstetric complications such as placental abruption, stillbirth, preeclampsia and recurrent miscarriage as a result of microthrombi in the placental circulation resulting in decreased uteroplacental perfusion (Gharavi et al, 2001;Dizon-Townson et al, 1997;Kupferminc et al, 1999;Coumans et al, 1999). However, the mechanisms by which adverse pregnancy outcomes are influenced by the presence of a thrombophilia are varied and obscure.…”

Section: Thrombophilia and Pregnancymentioning

confidence: 99%

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Inherited and Acquired Thrombophilia in Pregnancy

Dawood¹

2011

Thrombophilia

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Section: Hereditary Apcr (Factor V Leiden) and Pregnancy Lossmentioning

confidence: 89%

Section: Thrombophilia and Pregnancymentioning

confidence: 99%

Inherited and Acquired Thrombophilia in Pregnancy

Dawood¹

2011

Thrombophilia

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“…The association of fetal FVL with PTB that we report may indicate a causal relationship between thrombosis and preterm delivery. Our association analysis did not include mechanistic investigations, so we can only speculate that FVL may increase the likelihood of placental thrombus formation (19), a risk factor for preterm delivery (20).…”

Section: Discussionmentioning

confidence: 99%

Single-nucleotide polymorphism associations with preterm delivery: a case–control replication study and meta-analysis

et al. 2013

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Background:The aim of this study was to replicate singlenucleotide polymorphism (SNP) associations with preterm birth (PTB; birth at <37 completed weeks of gestation) and synthesize currently available evidence using meta-analysis. Methods: Spontaneous PTB cases and controls were selected from an existing cohort. Candidate SNPs were taken from an existing genotype panel. A systematic review was conducted for each SNP in the panel to determine suitability as a PTB candidate. Those with significant associations previously reported in Caucasians were selected for replication. Candidate SNPs were already genotyped in cases and controls and clinical data were accessed from state perinatal and cerebral palsy databases. Association analysis was conducted between each SNP and PTB, and meta-analysis was conducted if there were ≥3 studies in the literature. Maternal and fetal SNPs were considered as separate candidates. results: A cohort of 170 cases and 583 controls was formed. Eight SNPs from the original panel of genotyped SNPs were selected as PTB candidates and for replication on the basis of systematic literature review results. In our cohort, fetal factor V Leiden (FVL) was significantly associated with PTB (odds ratio (OR): 2.6, 95% confidence interval (CI): 1.31-5.17), and meta-analysis confirmed this association (OR: 2.71, 95% CI: 1.15-6.4). conclusion: Replication and meta-analysis support an increased risk of PTB in Caucasians with the fetal FVL mutation.

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“…По данным M. Kupferminc et al, 25-50 % па-циенток с отслойкой плаценты носят ген лей-деновской мутации [8], поэтому неотъемлемой частью ведения беременности является кон-троль за состоянием гемостаза и выявление ри-ска реализации скрытой тромбофилии [9,10].…”

Section: обсуждение и выводыunclassified

Asymptomatic placental abruption in the third trimester of pregnancy

et al. 2017

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1 ФГБНУ «НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта», Санкт-Петербург; 2 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» ■ The article presents 3 clinical cases of asymptomatic placental abruption, diagnosed occasionally during routine ultrasound. There were analyzed risk factors of placental abruption: thrombophlia, diabetes, perinatal losses. All cases demonstrated complete coincidence of ultrasonic and morphological data in placental abruption. The patients had been delivered successfully due to correct diagnostics and severe maternal and fetal complications were not realized.

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Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction

Cited by 238 publications

References 15 publications

Inherited and Acquired Thrombophilia in Pregnancy

Inherited and Acquired Thrombophilia in Pregnancy

Single-nucleotide polymorphism associations with preterm delivery: a case–control replication study and meta-analysis

Asymptomatic placental abruption in the third trimester of pregnancy

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