Inherited and Acquired Thrombophilia in Pregnancy

Dawood, Feroza

doi:10.5772/25542

Cited by 3 publications

(4 citation statements)

References 133 publications

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“…The findings of this study generally point to high levels of pandemicrelated trust. This is contrary to prior findings proving the Egyptian youth to have less trust in political institutions (Saleh, 2020;Bakry, 2018) and the Egyptian government (Dawood, 2011). This contradiction between the current and prior findings results from two key factors.…”

Section: Discussioncontrasting

confidence: 99%

“…(A) Independent Variable: However, this finding appears inconsistent with earlier research highlighting the low levels of trust in the Egyptian government in general (Dawood, 2011). Even structural transformations like the January 25th revolution couldn't fundamentally change Egyptians' relationship with power, characterized by distrust in the government and its decisions and a tendency to be more negative or critical of public institutions (Bakry, 2018).…”

Section: Main Findingsmentioning

confidence: 84%

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The Impact of Political Trust Among the Egyptian Youth on Adaptation to the COVID-19 Pandemic

Qamer

2023

المجلة العلمية لبحوث الإذاعة والتلفزيون

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This study aimed to test the impact of pandemic-related trust on the selfreported coping mechanisms of Egyptian youth in adapting to COVID-19 in the midst of the pandemic. Researcher-administered questionnaires were completed by a total of 610 respondents, ranging in age from 18 to 39 years old. Three simple regression models were employed using the MPlus general modeling program.Findings supported the three hypotheses, showing that pandemicrelated trust was a positive predictor for each of the three dimensions of adaptation to the COVID-19 pandemic: compliance with pandemic control measures, support for pandemic control measures, and acceptance of COVID-19 vaccines.

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Section: Discussioncontrasting

confidence: 99%

Section: Main Findingsmentioning

confidence: 84%

The Impact of Political Trust Among the Egyptian Youth on Adaptation to the COVID-19 Pandemic

Qamer

2023

المجلة العلمية لبحوث الإذاعة والتلفزيون

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“…Congenital hypercoagulability included prothrombin G20210A gene mutation, deficiencies in protein C and protein S, AT deficiency and a single-point mutation on the FVL. Acquired conditions usually result from trauma or surgery, certain medications while the APS has been identified as the most common acquired thrombophilia in the general population [20]. The genetic abnormalities of the fibrinolytic system are not common, however, the acquired hyperfibrinolysis has been identified as the major cause of severe haemorrhage [15].…”

Section: Virchow's Triadmentioning

confidence: 99%

“…Screening for undetected cancer and unexplained VTE in older patients, including patients history and physical examination, ESR, hepatic and renal function tests, urinalysis, and chest X-ray (XR), tumour markers, CT of the chest, abdomen and pelvis mammography in women above 40 years [20], prostate ultrasound in men of more than 50 years, lower endoscopy, Papanicolaou smear and faecal occult blood test are recommended. In patients with hypercoagulability syndromes, there is an increased risk of venous thrombosis than ischemic stroke.…”

Section: Investigations Of Hypercoagulabilitymentioning

confidence: 99%

Anticoagulants and Hypercoagulability

Kwaifa¹

2022

Anticoagulation - Current Perspectives

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Anticoagulants are chemical substances that prevent coagulation or prolong the clotting time by suppressing the functions or synthesis of coagulation factors in the blood. Anticoagulation mechanisms are essential in controlling the formation of a blood clot at the site of injury. The abnormalities in the coagulation and fibrinolytic mechanisms could lead to a hypercoagulability state. Inherited hypercoagulable state due, including Factor V Leiden (FVL), prothrombin gene mutation, defective natural proteins that inhibit coagulation, including antithrombin III (ATIII), protein C and S, high levels of FVII, FIX and FXI, are well-documented. Abnormalities of the fibrinolytic system, including tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator (u-PA), and elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been linked to hypercoagulation. Acquired conditions, including certain cancers and their medications, trauma or surgery, pregnancy, obesity and hyperlipidaemia, have been implicated with hypercoagulable events. The clinical symptoms of hypercoagulability can be devastating and may even have lethal outcomes. This activity reviews the principles of anticoagulation, haemostasis, deficiencies associated with hypercoagulability (both coagulation and fibrinolytic disorders), mechanisms of action of some natural-based products with anticoagulant potentials and highlights new clinical and traditional therapeutic strategies to be taken in improving healthcare for patients demanding anticoagulation.

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Etiology of recurrent pregnancy loss in Saudi females

Alghamdi

Makhashen

2016

Saudi J Med Med Sci

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Objective:The aim of our retrospective study was to assess the etiology of recurrent pregnancy loss (RPL) in Saudi couples attending a specialized RPL clinic at King Fahad Hospital of the University, Al-Khobar, Saudi Arabia.Patients and Methods:A total of 59 couples attending the RPL clinic between January 2010 and December 2013 and who had completed their workup and investigations for RPL were included in the study. Data were collected from patients’ charts and computer-based laboratory results.Results:Protein S deficiency was found in 47% of patients, a chromosomal abnormality in 6.7%, uterine abnormality in 12%, antiphospholipid syndrome (APS) in 12%, and antithrombin III and Protein C deficiency in 1.7%. However, no patient had Factor V Leiden mutation. In 39% of the patients, there was no identifiable cause, and therefore, they had been diagnosed as unexplained RPL.Conclusion:The most common cause of RPL was Protein S deficiency followed by congenital uterine anomalies and APS. Almost 40% of couples with RPL remain with unknown etiology.

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Inherited and Acquired Thrombophilia in Pregnancy

Cited by 3 publications

References 133 publications

The Impact of Political Trust Among the Egyptian Youth on Adaptation to the COVID-19 Pandemic

The Impact of Political Trust Among the Egyptian Youth on Adaptation to the COVID-19 Pandemic

Anticoagulants and Hypercoagulability

Etiology of recurrent pregnancy loss in Saudi females

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