Fetal brain activity demonstrated by functional magnetic resonance imaging

Hykin, Jonathan; Moore, Rachel J.; Duncan, Keith; Clare, Stuart; Baker, PN; Johnson, I. R.; Bowtell, Richard; Mansfield, P.; Gowland, Penny A.

doi:10.1016/s0140-6736(99)02901-3

Cited by 120 publications

(68 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, activation was consistently detected in the frontal lobes. Significant activation was recorded for more than 50% of the fetuses, which is similar to the sensitivity of previous fetal fMRI studies using acoustic stimuli [Hykin et al, 1999;Moore et al, 2001]. A very low sensitivity was found in adults.…”

Section: Figuresupporting

confidence: 86%

“…Functional magnetic resonance imaging (fMRI) has become a well-established method for determining the patterns of brain activation following stimulus presentation in the adult. Preliminary work has also shown that fMRI can be used in the fetus, in studies to determine brain activation following the presentation of an auditory stimulus [Hykin et al, 1999;Moore et al, 2001]. However, auditory stimuli pose a particular problem for fetal fMRI, since it is difficult to ensure that the sound of the stimulus is louder than the noise from the scanner for the fetus.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

101

View full text Add to dashboard Cite

Previous studies have demonstrated the use of functional magnetic resonance imaging (fMRI) to assess fetal brain activity. To extend these studies, a fetal fMRI experiment using a visual stimulus has been performed at 0.5 T. This used a block fMRI paradigm with a bright, constant-intensity light source being shone at the maternal abdomen for 8 sec followed by 16 sec of darkness. This was repeated typically 40 times on nine subjects all of whom were greater than 36 weeks gestational age. Of these, one could not be analysed due to motion, three did not show significant activation, and five showed significant activation (P < 0.0085). In all cases, activation was localised within the frontal cortex. Exact localisation was difficult but this may correspond to the frontal eye fields and dorsolateral prefontal cortex. In no cases was significant activation present within the occipital region as would have been expected and was observed in 2/8 adult subjects. Hum. Brain Mapping 20:239-245, 2003.

show abstract

Section: Figuresupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

101

View full text Add to dashboard Cite

show abstract

“…Indeed, the cortical auditory system of the human neonate is highly functional at birth [11,17] while the cortical visual system undergoes a more protracted development [18,19]. Several studies have also suggested that the human fetus can hear at 27 weeks' gestation [20,21], and a recent fMRI study has even shown auditory activation in fetal human brain [22]. The possibility that the auditory cortex functionally matures at a faster rate than the visual cortex also receives support from metabolic studies of the developing brain in both human and non-human primate infants [23,24].…”

Section: Discussionmentioning

confidence: 99%

Neonatal auditory activation detected by functional magnetic resonance imaging

Anderson

Marois

Colson

et al. 2001

Magnetic Resonance Imaging

153

113

View full text Add to dashboard Cite

The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants.

show abstract

“…1B) is interesting. The well documented dramatic development of the brain's various functional networks (Johnson, 1994;Gao et al, 2009aGao et al, , 2011Gao et al, , 2012Tau and Peterson, 2010;, and the concurrent robust development of gray and white matter (Mukherjee et al, ;Schneider et al, 2004;Gao et al, 2009b;Geng et al, 2012) during this period suggest that the first year of life may be characterized by the establishment of the "backbone" structures of most functional networks, which likely possess high degree of commonalities across individuals. Therefore, this "backbone" construction process may help explain the observed global decrease in variability during this period.…”

Section: The Temporal Development Of Intersubject Variability During mentioning

confidence: 99%