Fetal and Neonatal Erythropoiesis*

Lucarelli, G; Porcellini, A; Carnevali, C; Carmena, A; Stohlman, Frederick

doi:10.1111/j.1749-6632.1968.tb15194.x

Cited by 83 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, other factors probably exist in determining the rate of erythropoiesis in the neonate. Although starvation depresses erythropoiesis in adult rats (37), the opposite effect has been observed in neonatal rats (38), suggesting a possible mechanism for the observed increase in PCV of rats from large litters, irrespective of treatment group.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat

et al. 1988

View full text Add to dashboard Cite

ABSTRACT. Somatomedins are anabolic hormones that may stimulate growth during the perinatal period. To test this hypothesis, neonatal rats were injected with a biosynthetic somatomedin, insulin-like growth factor 1 (IGF-1) twice daily for the first 2 wk of life. Two biosynthetic IGF-1 preparations of different potency were tested as well as a preparation of human growth hormone in five litters of rats. When compared to saline-injected rats, IGF-1 injected rats had increased body weight and tail length as well as specific increases in weights of liver, brain, heart, and testes. In addition, significant increases in bone marrow erythropoietic cell precursors were apparent after IGF-1 injection. IGF-1-treated neonatal rats also exhibited precocious eye opening as a sign of epithelial cell differentiation. Five additional litters of rats received similar injections but were exposed to postnatal nutritional deprivation via artificially increasing litter size. Although IGF-1 caused stimulation of bone marrow erythropoiesis and precocious eye opening, no effects of IGF-1 on somatic or organ growth could be documented. This represents the first demonstration in vivo of the anabolic effects of IGF-1 in rapidly growing neonatal rats but suggests that nutritional sufficiency may also be necessary for the full expression of somatomedin effects. (Pediatr Res 23: 298-305, 1988)

show abstract

Section: Resultsmentioning

confidence: 99%

The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat

et al. 1988

View full text Add to dashboard Cite

show abstract

“…However, the difference in estimated O2 delivery capacity of the blood from the 22nd and to the 29th day was probably small, and the marked increase in plasma ESF may also reflect that the regions governing erythropoietin production/release became increasingly sensitive to low O2 tension at this stage of development (10). The rise in plasma ESF could also be due to shift from extrarenal to renal erythropoietin production (6,24,25).…”

Section: Discussionmentioning

confidence: 99%

Regulation of Erythropoiesis in Suckling Rabbits with and without Postnatal Anemia: Partial Suppression of Production/Release of Erythropoiesis Stimulating Factor(s) by Iron Supplements

et al. 1987

View full text Add to dashboard Cite

“…By the latter part of in response to physiological demand (Gurney, day 10 of gestation, hepatic erythropoiesis begins 1968) . The role of this hormone in the regulation (Rifkind et al ., 1969 b), and the sequential difof neonatal and fetal erythropoiesis, however, remains less conclusively documented (Halvorsen, 1963 ;Carmena et al ., 1968 ;Lucarelli et al ., 1968) . In long-term organ culture of fetal liver, serum from anemic animals induced the appearance and persistence of early erythroid precursors (Gallien-Lartigue, 1967 ; Salvatorelli et al, 1969) .…”

Section: Introductionmentioning

confidence: 99%

Erythropoietin Effects on Fetal Mouse Erythroid Cells

Chui

Djaldetti

Marks

et al. 1971

The Journal of Cell Biology

View full text Add to dashboard Cite

The effect of the hormone, erythropoietin, on cultures of erythroblasts derived from the livers of fetal C57BL/6J mice was examined . An increase both in the content and in the rate of synthesis of normal adult mouse globin chains was detected in hormone-treated cultures . The rate of protein synthesis by individual erythroblasts does not increase in response to the hormone, whereas the absolute number of hemoglobin-synthesizing cells does increase and accounts for the observed stimulation of hemoglobin synthesis . The principal effect of erythropoietin appears to be upon the population of immature erythroid precursor cells which persists in the presence of the hormone, the cells maintaining their ability to replicate, and their capacity to differentiate into hemoglobinizing erythroblasts . In the absence of hormone, already committed erythroblasts continue their development, but erythropoiesis is not sustained .

show abstract

Fetal and Neonatal Erythropoiesis*

Cited by 83 publications

References 6 publications

The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat

The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat

Regulation of Erythropoiesis in Suckling Rabbits with and without Postnatal Anemia: Partial Suppression of Production/Release of Erythropoiesis Stimulating Factor(s) by Iron Supplements

Erythropoietin Effects on Fetal Mouse Erythroid Cells

Contact Info

Product

Resources

About