Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature

Yazigi, Alexandre; Pecoulas, Aurelia Eldin De; Vauloup‐Fellous, Christelle; Grangeot-Keros, L.; Ayoubi, Jean-Marc; Picone, Olivier

doi:10.3109/14767058.2016.1169526

Cited by 70 publications

(48 citation statements)

References 29 publications

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“…Further studies are needed to delineate the pathogenic role of enhanced type I IFN for CHB development. Notably, there might be a time window during gestation where this factor becomes a driver of immunopathology, as exemplified by rubella virus infection that also affects the fetal heart within a defined susceptibility phase20 and where IFN-α induction is also likely to be involved.…”

Section: Discussionmentioning

confidence: 99%

High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block

et al. 2017

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Section: Discussionmentioning

confidence: 99%

High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block

et al. 2017

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“…The major signs including the ocular, cardiac and auditory signs were often the most known by the care provider because of their frequency and these noisy manifestations in CRS. 8,9 This knowledge can lead health care providers to think immediately towards CRS diagnosis and thus avoid a potential case of CRS escaping them. However, the rubella etiology often remains insufficiently exploited or known by the healthcare providers.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitude, and practice of care providers about congenital rubella syndrome

Ravaoarisoa¹,

Andriatahina²,

Randriananahirana³

et al. 2020

Int J Res Med Sci

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Background: Behaviour of healthcare providers when facing an illness is an important part of their struggle. The aim of this study was to assess the level of knowledge, the attitude and the practice of health care providers regarding to the Congenital Rubella Syndrome.Methods: Authors did a descriptive study on the knowledge, the attitude and the practice of healthcare providers about Congenital Rubella Syndrome with 161 healthcare providers working in 8 hospitals in Madagascar. A self-introduced survey was used to collect the data.Results: There were 87% of all healthcare providers included in the study, who said that rubella in the first trimester of pregnancy was the cause of this syndrome for child, 87% knew at least 2 of the 3 major signs of Congenital Rubella Syndrome and more than 80% had a good knowledge of the criteria for diagnosing cases (suspected, clinically confirmed, laboratory confirmed). The referral to a hospital or to a specialist was the most proposed for the management of the case of Congenital Rubella Syndrome. The prescription of an IgG avidity for rubella and advising abortion were the main propositions for mothers having a positive test at the first trimester of pregnancy.Conclusions: A fairly satisfactory level of knowledge of healthcare providers was noted.

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“…Congenital infection caused by Toxoplasma gondii and rubella can cause serious damage to the newborn [1, 4] that can be diagnosed in utero or at birth [5–7]. Although these infections are rare in most developed countries, they still represent a major risk for pregnant women in developing regions [8].…”

Section: Discussionmentioning

confidence: 99%

Fetal malformation in maternal toxoplasma and rubella co-infection in Cameroon: a case report

Njoh

Abizou

2016

J Med Case Reports

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BackgroundThere has been a recent increase in the number of newborns with brain malformations due to congenital infections, but the impact of these diseases remains largely under ascertained in middle-income and low-income countries. This case report presents a fetal anencephaly following maternal toxoplasma and rubella co-infection in a resource-limited setting and the challenges faced by the patient and the health care provider in the management of the condition.Case presentationA 25-year-old black Cameroonian woman of Bakossi origin, gravida3 para1010, presented with a positive rubella and toxoplasma immunoglobulin G serologic test at 21 weeks of pregnancy; she could not benefit from a fetal morphologic ultrasound partly because there was none at the site of her antenatal clinic and because there were accessibility constraints getting to the nearest referral hospital approximately 100 km away. She returned to the hospital in labor pains 14 weeks later and, upon examination, she was observed to be at almost full cervical dilatation and had a stillbirth a few minutes later; a baby boy weighing 1600 g with anencephaly.The devastated parents of the baby were counseled and given psychological support. She was discharged from hospital 3 days later and now benefits from continual follow up as out-patient. She was advised to consult a gynecologist-obstetrician before her next pregnancy.ConclusionMuch attention still has to be paid to ameliorate the health care in resource-limited settings where pregnant women generally obtain less than adequate care.Electronic supplementary materialThe online version of this article (doi:10.1186/s13256-016-1133-y) contains supplementary material, which is available to authorized users.

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Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature

Abstract: This extensive literature review shows that the ultrasound features of CRS are not well known, even though rubella was the first teratogenic virus described. This review will help clinicians in the management of rubella during pregnancy by clarifying the findings to be sought.

Cited by 70 publications

References 29 publications

High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block

High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block

Knowledge, attitude, and practice of care providers about congenital rubella syndrome

Fetal malformation in maternal toxoplasma and rubella co-infection in Cameroon: a case report

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