Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor

Cardin, John P.; Ross, Michael G.; Ervin, M. Gore; Victoria^Schaffer, A.; Douglas, Frank L.; Simke, John P.

doi:10.1016/0002-9378(90)90717-l

Cited by 10 publications

References 22 publications

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Effects of a 48 hour continous intravenous infusion of CGS 13080‐primagrel, a selective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig

et al. 1992

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CGS 13080, imidazo[1,5-a]pyridine-5-hexanoic acid, was evaluated for perinatal and postnatal effects in third trimester pregnant guinea pigs and their offspring. The compound was administered via 48 hour continuous intravenous infusion to a group of pregnant guinea pigs (n = 16) at a dose of 3 mg/kg/hr starting on gestational day 52 (via chronically implanted indwelling jugular venous cannulas). A saline control group (n = 12) received equivalent volumes of normal saline 0.5 ml/kg/hr throughout the dosing period. A third group (surgery-sham, n = 16) was subjected to cannulation but not infused. A gross examination of each dam and piglets was conducted at necropsy on day 5 of lactation. The neonatal brains and all gross lesions (maternal and neonatal) were removed and fixed for histopathological examination. Compound-related clinical signs were noted in dams during the dosing phase of gestation. Six guinea pigs developed cephalic lymphatic swelling during the infusion. This observation may be correlated to the reported redistribution of fluid volume to the thorax of guinea pigs given intravenous injections of CGS 13080. There were no compound-induced effects on labor, delivery, or any of the examined reproductive parameters. There were no compound-related clinical signs, or effects on survival, body weight and developmental parameters in the F1 generation. Histopathological examination of the brains and other organs did not reveal any compound-related abnormalities. Based on these results, it was concluded that CGS 13080 did not elicit adverse perinatal and postnatal effects in guinea pigs.

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Effects of a 48 hour continous intravenous infusion of CGS 13080‐primagrel, a selective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig

et al. 1992

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Intensivtherapie bei Gestose

Frey¹

1994

Aktuelles Wissen Für Anästhesisten

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Vaso-active factors in pregnancy

Myatt

1992

Fet. Matern. Med. Rev.

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Pregnancy results in profound physiological changes in the cardiovascular system, yet these changes are completely reversible. It is apparent that vaso-active factors, some as yet probably unidentified, which act as humoral or local autocrine or paracrine regulators of vasular resistance, play a major role in these cardio-vascular changes. This role may be heightened in pregnancy when there has to be a large increase in blood flow to the uterus and placenta while maintaining adequate flow to other vascular beds. Our knowledge of the mechanisms of action of these vaso-active factors and their interactions with each other still remains incomplete. Alterations in synthesis and action of these vaso-active factors may occur in pregnancies associated with pregnancy-induced hypertension, pre-eclampsia or intra-uterine growth retardation. Investigation of such alterations may help to elucidate the roles of vaso-active factors in both normal and pathological situations. The gestational hormones oestrogen and progesterone, are obviously prime candidates as overall regulators of the cardiovascular changes of pregnancy and as agents which alter the synthesis or action of other vaso-active factors. Currently, much attention is being focused on the role of local autocrine or paracrine vaso-active factors which may be produced by the endothelium or by the underlying vascular smooth muscle cells and alterations in their production or action in the hyptertensive disorders of pregnancy. The endothelium forms the largest endocrine organ within the body and so its importance in the mediation of vascular events should not be under-estimated. The principal objective of this review is to examine the roles of these many autocrine and paracrine vaso-active factors during pregnancy and their relation with the overall regulation of the vascular system. Changes which may occur and be involved in the aetiology of pre-eclampsia and growth retardation will also be examined.

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Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor

Cited by 10 publications

References 22 publications

Effects of a 48 hour continous intravenous infusion of CGS 13080‐primagrel, a selective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig

Effects of a 48 hour continous intravenous infusion of CGS 13080‐primagrel, a selective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig

Intensivtherapie bei Gestose

Vaso-active factors in pregnancy

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