Fetal and Birth Experiences: Proximate Effects, Developmental Consequences, Epigenetic Legacies

Ronca, April E.; Alberts, Jeffrey R.

doi:10.1007/978-3-319-22023-9_2

Cited by 6 publications

(7 citation statements)

References 105 publications

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“…The low hearing threshold of preterm babies is around 10-15 dB at a frequency range of 500-5,000 Hz with an overall auditory range of 10-30 dB (3)(4)(5)(6)(7)(8)(9)(10)(11). Auditory range will be tested of each child to determine the best sound environment and level within the determined and certified maximum levels (13,14,16,17,20,21).…”

Section: Methodsmentioning

confidence: 99%

“…The human auditory system has its own developmental cycle with anatomical parts like the cochlea in the middle ear being well formed by 15 weeks' gestational age (3). At 20 weeks, this structure is anatomically functional and the infant will need auditory experiences like language, music, and meaningful environmental sounds during the last 10-12 weeks of foetal life (3)(4)(5). At 25-29 weeks, the auditory system becomes functional connecting inner hair cells of the cochlea to the brain stem, thalamus, and temporal lobe.…”

Section: Introductionmentioning

confidence: 99%

“…At 25-29 weeks, the auditory system becomes functional connecting inner hair cells of the cochlea to the brain stem, thalamus, and temporal lobe. Loud and prolonged noises affect the infants' hearing through changes in autonomic functions and impact heart rate, blood pressure, respiratory patterns, gastrointestinal motility, and, in turn, neural connectivity (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Concept and considerations of a medical device: the active noise cancelling incubator

Jaschke

Bos

2023

Front. Pediatr.

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BackgroundAn increasingly 24/7 connected and urbanised world has created a silent pandemic of noise-induced hearing loss. Ensuring survival to children born (extremely) preterm is crucial. The incubator is a closed medical device, modifying the internal climate, and thus providing an environment for the child, as safe, warm, and comfortable as possible. While sound outside the incubator is managed and has decreased over the years, managing the noise inside the incubator is still a challenge.MethodUsing active noise cancelling in an incubator will eliminate unwanted sounds (i.e., from the respirator and heating) inside the incubator, and by adding sophisticated algorithms, normal human speech, neonatal intensive care unit music-based therapeutic interventions, and natural sounds will be sustained for the child in the pod. Applying different methods such as active noise cancelling, motion capture, sonological engineering. and sophisticated machine learning algorithms will be implemented in the development of the incubator.Projected ResultsA controlled and active sound environment in and around the incubator can in turn promote the wellbeing, neural development, and speech development of the child and minimise distress caused by unwanted noises. While developing the hardware and software pose individual challenges, it is about the system design and aspects contributing to it. On the one hand, it is crucial to measure the auditory range and frequencies in the incubator, as well as the predictable sounds that will have to be played back into the environment. On the other, there are many technical issues that have to be addressed when it comes to algorithms, datasets, delay, microphone technology, transducers, convergence, tracking, impulse control and noise rejection, noise mitigation stability, detection, polarity, and performance.ConclusionSolving a complex problem like this, however, requires a de-disciplinary approach, where each discipline will realise its own shortcomings and boundaries, and in turn will allow for innovations and new avenues. Technical developments used for building the active noise cancellation-incubator have the potential to contribute to improved care solutions for patients, both infants and adults.Code available at: 10.3389/fped.2023.1187815.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Concept and considerations of a medical device: the active noise cancelling incubator

Jaschke

Bos

2023

Front. Pediatr.

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“…The perceptual, cognitive, or social consequences of this long-term alteration in tactile/vestibular stimulation during late prenatal development are currently not well understood, and animal-based research can provide an important first step at generating new questions to pursue with this high-risk population. Working with a rodent model, Ronca and Alberts (2016) have quantified the prenatal sensory experience of the rat fetus and documented the extent to which maternal activity provide fetuses sensory experiences of acceleration, pressure, and vibration. This rich flux of ongoing prenatal stimuli has potential implications for sensory, neural, and physiological systems of mammals, including humans (see Previc, 1991).…”

Section: Exploring the Role Of Prenatal Sensory Experience On Perceptmentioning

confidence: 99%

The influence of prenatal experience on behavioral and social development: The benefits and limitations of an animal model

Lickliter

2018

Dev Psychopathol

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Prenatal experience is both a formative and a regulatory force in the process of development. As a result, birth is not an adequate starting point for explanations of behavioral development. However, surprisingly little is currently known regarding the role of prenatal experience in the emergence and facilitation of perceptual, cognitive, or social development. Our lack of knowledge in this area is due in part to the very restricted experimental manipulations possible with human fetuses. A comparative approach utilizing animal models provides an essential step in addressing this gap in our knowledge and providing testable predictions for studies with human fetuses, infants, and children. Further, animal-based comparative research serves to minimize the amount of exploratory research undertaken with human subjects and hone in on issues and research directions worthy of further research investment. In this article, I review selected animal-based research exploring how developmental influences during the prenatal period can guide and constrain subsequent behavioral and social development. I then discuss the importance of linking the prenatal environment to postnatal outcomes in terms of how psychologists conceptualize "innate" biases, preferences, and skills in the study of human development.

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“…Further, prenatal exposure to drugs of abuse may impact both short-and long-term neurohormonal control systems. Specifically, low CAT levels at birth can significantly delay or impede key development milestones (19).…”

Section: Introductionmentioning

confidence: 99%

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

Soucy

Burchett

Brady

et al. 2020

Preprint

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The transition to extrauterine life results in a critical surge of catecholamines necessary for increased cardiovascular, respiratory, and metabolic activity. The mechanisms mediating adrenomedullary catecholamine release are poorly understood, given the sympathetic adrenomedullary control systems' functional immaturity. Important mechanistic insight is provided by newborns delivered by cesarean section or subjected to prenatal nicotine or opioid exposure, demonstrating the impaired release of adrenomedullary catecholamines. To investigate mechanisms regulating adrenomedullary innervation, we developed compartmentalized 3D microphysiological systems (MPS) by exploiting the meniscus pinning effect via GelPins, capillary pressure barriers between cell-laden hydrogels. The MPS comprises discrete 3D cultures of adrenal chromaffin cells and preganglionic sympathetic neurons within a contiguous bioengineered microtissue. Using this model, we demonstrate that adrenal chromaffin innervation plays a critical role in hypoxia-medicated catecholamine release. Furthermore, opioids and nicotine were shown to affect adrenal chromaffin cell response to a reduced oxygen environment, but neurogenic control mechanisms remained intact. GelPin containing MPS represent an inexpensive and highly adaptable approach to study innervated organ systems and improve drug screening platforms by providing innervated microenvironments.

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Fetal and Birth Experiences: Proximate Effects, Developmental Consequences, Epigenetic Legacies

Cited by 6 publications

References 105 publications

Concept and considerations of a medical device: the active noise cancelling incubator

Concept and considerations of a medical device: the active noise cancelling incubator

The influence of prenatal experience on behavioral and social development: The benefits and limitations of an animal model

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

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