Ferutinin, an Apoptosis Inducing Terpenoid from Ferula ovina

Matin, Maryam Moghaddam; Nakhaeizadeh, Hossein; Bahrami, Ahmad Reza; Iranshahi, Mehrdad; Arghiani, Nahid; Rassouli, Fatemeh Behnam

doi:10.7314/apjcp.2014.15.5.2123

Cited by 23 publications

(15 citation statements)

References 44 publications

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“…Numerous studies reported marked toxicity of ferutinin to cancer cells compared to non-tumoural cells. In experiments in vivo, the antitumor activity of ferutinin was similar to the activity of cisplatin (Matin et al 2014;Arghiani et al 2014). Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells (Arghiani et al 2014;Lhuillier et al 2005;Macho et al 2004).…”

Section: Introductionmentioning

confidence: 77%

“…Therefore, it was of interest to study the mechanism(s) of the ferutinin effect on isolated mitochondria and estimate a possible role of mitochondrial functional changes in anticancer activity of ferutinin. It was suggested that ferutinin, due to high cytotoxic and apoptosis-inducing activities in different lines of cancer cells, could be considered as an effective anticancer agent for future experiments, both in vivo and in the clinical studies (Matin et al 2014). The aim of the present work was to evaluate the effects of ferutinin on mitochondrial respiration, MPT pore formation, and membrane potential both in the absence and the presence of calcium ions using isolated rat liver mitochondria.…”

Section: Introductionmentioning

confidence: 99%

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Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca2+-Permeability

et al. 2018

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It is well known that the terpenoid ferutinin (4-oxy-6-(4-oxybenzoyloxy) dauc-8,9-en), isolated from the plant Ferula tenuisecta, considerably increases the permeability of artificial and cellular membranes to Ca-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. The present study was designed for further evaluation of the mechanism(s) of mitochondrial effects of ferutinin using isolated rat liver mitochondria. Our findings provide evidence for ferutinin at concentrations of 5-27 µM to decrease state 3 respiration and the acceptor control ratio in the case of glutamate/malate as substrates. Ferutinin alone (10-60 µM) also dose-dependently dissipated membrane potential. In the presence of Ca-ions, ferutinin (10-60 µM) induced considerable depolarization of the inner mitochondrial membrane, which was partially inhibited by EGTA, and permeability transition pore formation, which was diminished partly by cyclosporin A, and did not influence markedly the effect of Ca on mitochondrial respiration. Ruthenium Red, a specific inhibitor of mitochondrial calcium uniporter, completely inhibited Ca-induced mitochondria swelling and membrane depolarization, but did not affect markedly the stimulation of these Ca-dependent processes by ferutinin. We concluded that the mitochondrial effects of ferutinin might be primarily induced by stimulation of mitochondrial membrane Ca-permeability, but other mechanisms, such as driving of univalent cations, might be involved.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca2+-Permeability

et al. 2018

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“…Moreover, a number of studies indicate that ferutinin had cytotoxic and antitumor effects [3,4,77]. For example, ferutinin has antitumor activities in human colon cancer and pro-apoptotic effects in the human T cell leukemia line through the activation of the intrinsic apoptotic pathway by opening the mitochondrial permeability transition pores [78,79].…”

Section: Biological Properties Of Ferutininmentioning

confidence: 99%

“…Ferula hermonis Boiss. and other medicinal Ferula species such as F. gummosa and F. assa-foetida are perennial plants, which belong to the family Apiaceae [1][2][3][4]. F. hermonis is an endemic plant that can be found in a very restricted eco-geographic zones including Lebanon and Syria [5].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry and Pharmacology of Ferula hermonis Boiss. – A Review

Sattar

Iranshahi

2017

Drug Res (Stuttg)

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Ferula hermonis, a well-known species of the genus Ferula found in Lebanon and Syria, has a brilliant history in traditional medicine as it has been used for the treatment of erectile dysfunction in men and menopausal disturbances in women. Thanks to modern pharmacological and clinical investigations, is a valuable medicinal and condimental plant that may be used for the treatment of impotence and diabetes, the prevention of osteoporosis, and possesses anti-microbial and anti-inflammatory properties. Phytochemical investigations have shown that this plant contains daucane aryl esters such as ferutinin, which has exhibited various biological activities including hypoglycemic and estrogenic activities. Ferutinin is one of the strongest natural phytoestrogen which has agonistic activity on estrogen receptors, particularly α receptor. It seems that ferutinin and its derivatives play an important role in biological activities, mainly the beneficial effects of this plant on impotence, diabetes and osteoporosis. The present review discusses the available data on the active constituents and biological activities of and their possible underlying mechanisms of action.

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“…The DAPI staining was performed as previously described (Matin et al, 2014). Briefly, MCF-7 cells were seeded on coverslips with different concentrations of 20 (S)-PPD for 24h.…”

Section: Dapi Stainingmentioning

confidence: 99%