Phytochemistry and Pharmacology of Ferula hermonis Boiss. – A Review

Sattar, Zohreh; Iranshahi, Mehrdad

doi:10.1055/s-0043-109100

Cited by 27 publications

(20 citation statements)

References 73 publications

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“…Ferula species from the family Apiaceae are rich sources of biologically active natural products including sesquiterpene coumarins (SCs) and sesquiterpenes [48]. Some studies have shown that SCs are able to enhance the cytotoxicity of anticancer compounds [49].…”

Section: Discussionmentioning

confidence: 99%

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling

Zhang

Gui

et al. 2019

IJMS

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Background: G-protein-coupled bile acid receptor (TGR5), a membrane bile acid receptor, regulates macrophage reactivity, and attenuates inflammation in different disease models. However, the regulatory effects of TGR5 in ischemia/reperfusion (I/R)-induced kidney injury and inflammation have not yet been extensively studied. Therefore, we hypothesize that Farnesiferol B, a natural TGR5 agonist, could alleviate renal I/R injury by reducing inflammation and macrophage migration through activating TGR5. Methods: Mice were treated with Farnesiferol B before I/R or sham procedures. Renal function, pathological analysis, and inflammatory mediators were examined. In vitro, the regulatory effects of Farnesiferol B on the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway in macrophages were investigated. Results: After I/R, Farnesiferol B-treated mice displayed better renal function and less tubular damage. Farnesiferol B reduced renal oxidative stress and inflammation significantly. In vitro, Farnesiferol B treatment alleviated lipopolysaccharide (LPS)-induced macrophage migration and activation, as well as LPS-induced NF-κB activation through TGR5. Conclusions: Farnesiferol B could protect kidney function from I/R-induced damage by attenuating inflammation though activating TGR5 in macrophages. Farnesiferol B might be a potent TGR5 ligand for the treatment of I/R-induced renal inflammation.

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Section: Discussionmentioning

confidence: 99%

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling

Zhang

Gui

et al. 2019

IJMS

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“…There is a large number of medicinal species in Iran, and some of the most important ones belong to the genus Ferula (Apiaceae), which includes about 213 species based on The Plant List (2013). In Iran, Ferula is represented by 30 species, of which 15 are endemic (Sattar and Iranshahi, 2017), and almost all of them are perennials. Ferula ovina is an Iranian Ferula , and is spread across vast areas in the eastern and central parts of the country at altitudes of 2000‒4000 m with an average annual precipitation of 350‒700 mm (Safaian and Shokri, 1993).…”

Section: Introductionmentioning

confidence: 99%

The morphophysiological dormancy of Ferula ovina seeds is alleviated by low temperature and hydrogen peroxide

Fasih

Afshari

2018

Seed Sci. Res.

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Ferula ovina is a perennial Apiaceae with great medicinal and economic value. This study was conducted to better understand the dormancy and germination behaviour of its seeds. Experiments included temperature requirements for both embryo growth and germination under field and laboratory conditions, the effects of warm stratification, gibberellic acid (GA3), dry after-ripening, exogenous hydrogen peroxide (H2O2) and diphenyleneiodonium (DPI) on dormancy, localizing the accumulation of superoxide (O2−) and measuring endogenous contents of H2O2 in embryos during cold and warm stratification. Embryos were under-developed and did not germinate within one month at temperatures higher than 10°C. Among all treatments, cold stratification and exogenous H2O2 could break dormancy. However, the application of DPI reduced growth and the germination of the embryo at 3°C. During cold stratification, the embryonic axes elongated more than the cotyledons, which coincided with earlier production of O2− in the axes. Only these embryos could eventually complete growth and germinate. Moreover, such asymmetric growth between the axes and cotyledons was also observed when seeds were treated with exogenous H2O2. On the other hand, both axes and cotyledons displayed the same growth over treatments with warm stratification and DPI. Overall, seeds of F. ovina exhibit the characteristics of deep complex morphophysiological dormancy. Moreover, the embryos solely require cold to complete growth and to germinate, and this process seems to be mediated by reactive oxygen species. Under natural conditions, seeds germinate during winter in cold soil, and shoots emerge in spring.

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“…[20,21] Overall, it was suggested that UMB may contribute to the antioxidant and anti-inflammatory properties of F. persica Willd. [22] Anti-inflammatory effects of UMB in animal models resemble those of non-steroidal anti-inflammatory drugs (NSAIDs), which render UMB an attractive alternative for evaluation in all pain models including neuropathic pain. [16] Chemotherapy-induced neuropathic pain still remains a clinical issue requiring effective treatment, despite the considerable research and efforts directed to this end.…”

Section: Introductionmentioning

confidence: 99%

“…persica Willd. [ 22 ] Anti‐inflammatory effects of UMB in animal models resemble those of non‐steroidal anti‐inflammatory drugs (NSAIDs), which render UMB an attractive alternative for evaluation in all pain models including neuropathic pain. [ 16 ]…”

Section: Introductionmentioning

confidence: 99%

Umbelliprenin relieves paclitaxel-induced neuropathy

Shahraki

Rezaee

Kenar

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant and inhibits lipoxygenase managing the inflammation pathways, while in vivo it exerts anti-inflammatory activities. Methods In this study, neuropathic pain was induced by four intraperitoneal doses of 2 mg/kg per day of paclitaxel (PTX) on days 1, 3, 5 and 7. Here, 49 male mice were randomly divided in the following groups: sham (not treated animals), negative control (PTX-treated receiving normal saline), single-dose UMB 6.25, 12.5 and 25 mg/kg groups (PTX-treated receiving UMB 6.25, 12.5 and 25 mg/kg, respectively), prevention (PTX-treated receiving PTX along with UMB 12.5 mg/ kg on days 1, 3, 5 and 7) and positive control group (PTX-treated receiving imipramine 10 mg/kg as acute treatment). Hot-plate test was done to assess response to heat. Finally, interleukin (IL)-6 levels in the sciatic nerve and lipid peroxidation in sera were assessed. Key findings Umbelliprenin was found equally effective for acute treatment with imipramine, when comparing the prevention group and the positive control group. Single, 25 mg/kg UMB effectively attenuated hyperalgesia, lipid peroxidation and IL-6 levels. Conclusions Umbelliprenin alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings.

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Phytochemistry and Pharmacology of Ferula hermonis Boiss. – A Review

Cited by 27 publications

References 73 publications

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling

The morphophysiological dormancy of Ferula ovina seeds is alleviated by low temperature and hydrogen peroxide

Umbelliprenin relieves paclitaxel-induced neuropathy

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