Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1

El‐Mesallamy, Hala O.; Gawish, Rania A.; Sallam, Al-Aliaa M.; Fahmy, Hanan A.; Nada, Ahmed S.

doi:10.1007/s11356-017-0873-6

Cited by 33 publications

(22 citation statements)

References 28 publications

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“…Moreover, de Boer et al (2006) stated that quercitin, a phenolic compound inhibits silent information regulators (SIRT1) activity due to its ability to form sIRT 1 inhibatory metabolites. This was in accordance with EL-Mesallamy et al (2018). Inhibition of sIRT1 decreases cellular resistance to oxidative stress, activates both NF_ kB & proinfilamatory cytokines and promotes cellular apoptosis (Chung et al, 2010).…”

Section: Discussionsupporting

confidence: 77%

The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats

2019

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T hIs sTuDy aims to evaluate the radioprotective effect of Ferulic acid (FA) against ovarian damage in premature female rats. Four groups of female rats were used (ten rats in each group). Group (1): Control, Group (2): Irradiation (IRR) (rats were exposed to 4Gy of whole body gamma irradiation as a single dose), Group (3): FA (rats received 50mg/kg b.wt of Ferulic acid orally for two weeks) and Group (4): FA+IRR (rats received Ferulic acid as group 3 then exposed to 4Gy as group2). The rats were sacrificed after 24h of irradiation. The level of FSH, LH, and E 2 were estimated in the serum. The level of H 2 O 2 and GPx activity and the gene expression of cytochrome C, P53 and caspase3 were evaluated in ovarian tissue. Histopathological examination of the ovary and uterus tissues was performed. The results revealed that gamma irradiation caused an elevation in FSH, LH, H 2 O 2 , cytochrome C, P53 and caspase3 and a decline in E 2 and GPx. The administration of FA prior gamma irradiation led to an improvement in female hormones, H 2 O 2 , GPx and apoptotic markers and matched the histopathological examination results. It could be concluded that Ferulic acid may exert a radioprotective effect against irradiation induced apoptosis in the ovary of rats and alteration in the level of serum female hormones.

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Section: Discussionsupporting

confidence: 77%

The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats

2019

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“…Bars with different superscripts are significantly different at p ˂ 0.05 obviously stimulated SIRT1 expression in a dose-dependent and time-dependent manner. Similar effects were also observed in FA-treated skeletal muscle cells, bone, and testis [62][63][64]. Second, genetically knocking down SIRT1 robustly abolished FA-stimulated autophagy induction.…”

Section: Discussionsupporting

confidence: 61%

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Song

Zhou

et al. 2021

Nutr Metab (Lond)

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Background Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against hepatic lipotoxicity are largely unclear. Here, we investigated the protective effect of ferulic acid against palmitate-induced lipotoxicity and clarified its potential mechanisms in AML-12 hepatocytes. Methods AML-12 mouse hepatocytes were exposed to palmitate to mimic lipotoxicity. Different doses (25, 50, and 100 μM) of ferulic acid were added 2 h before palmitate treatment. Cell viability was detected by measuring lactate dehydrogenase release, nuclear staining, and the expression of cleaved-caspase-3. Intracellular reactive oxygen species content and mitochondrial membrane potential were analysed by fluorescent probes. The potential mechanisms were explored by molecular biological methods, including Western blotting and quantitative real-time PCR, and were further verified by siRNA interference. Results Our data showed that ferulic acid significantly inhibited palmitate-induced cell death, rescued mitochondrial membrane potential, reduced reactive oxygen species accumulation, and decreased inflammatory factor activation, including IL-6 and IL-1beta. Ferulic acid significantly stimulated autophagy in hepatocytes, whereas autophagy suppression blocked the protective effect of ferulic acid against lipotoxicity. Ferulic acid-activated autophagy, which was triggered by SIRT1 upregulation, was mechanistically involved in its anti-lipotoxicity effects. SIRT1 silencing blocked most beneficial changes induced by ferulic acid. Conclusions We demonstrated that the phytochemical ferulic acid, which is found in plant-based food, protected against hepatic lipotoxicity, through the SIRT1/autophagy pathway. Increased intake of ferulic acid-enriched food is a potential strategy to prevent and/or improve metabolic diseases with lipotoxicity as a typical pathological feature.

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“…In animal studies, SIRT1 was reported to regulate acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice (24). Recent findings revealed that ferulic acid protects male rats against radiation-induced testicular damage by increasing SIRT1 expression (25). Existing evidence indicates the importance of SIRT1 in the male reproductive system.…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

et al. 2020

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The objective of this study was to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats. Compared to the control group, blood glucose levels were significantly increased and the insulin resistance was markedly aggravated in STZ-induced diabetic rats. Further, the weight of testis and epididymis and the sperm number and motility were decreased in diabetic rats. Pathological changes were also observed in the spermatogenic tubules, along with a decreased number of spermatogenic cells, downregulated proliferating cell nuclear antigen (PCNA) expression, and increased cell apoptosis in the testes. Compared to the saline-treated diabetic rat group, metformin and LBP treatment significantly decreased the level of blood glucose and improved insulin resistance and testicular function. After treatment with metformin and LBP, the pathological changes in the spermatogenic tubules improved significantly, with an increase in the number of spermatogenic cells, upregulation of PCNA, and suppression of apoptosis in the testes. The expressions of sirtuin 1 (SIRT1) and hypoxia-inducible factor 1-alpha (HIF-1α) in diabetic testes were also upregulated by metformin or LBP treatment. In summary, LBP exerted protective effects by increasing cell proliferation, inhibiting cell apoptosis, and regulating SIRT1/HIF-1α expression in the testes of diabetic rats.

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Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1

Cited by 33 publications

References 28 publications

The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats

The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

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