Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat

Abstract

Ferulic acid (FA) is a phenolic phytochemical known for its antidiabetic property The present study is designed to evaluate the mechanism behind its antidiabetic property in high-fat and fructose-induced type 2 diabetic adult male rats. Animals were divided into 5 groups: (i) control, (ii) diabetic control, (iii) diabetic animals treated with FA (50 mg/(kg body weight · day)(-1), orally) for 30 days, (iv) diabetic animals treated with metformin (50 mg/(kg body weight · day)(-1), orally) for 30 days, and (v) control rats treated with FA. FA treatment to diabetic animals restored blood glucose, serum insulin, glucose tolerance, and insulin tolerance to normal range. Hepatic glycogen concentration, activity of glycogen synthase, and glucokinase were significantly decreased, whereas activity of glycogen phosphorylase and enzymes of gluconeogenesis (phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase)) were increased in diabetic animals and FA restored these to normal levels similar to that of metformin. FA improved the insulin signalling molecules and reduced the negative regulators of insulin signalling. The messenger RNA of gluconeogenic enzyme genes (PEPCK and G6Pase) and the interaction between forkhead transcription factor-O1 and promoters of gluconeogenic enzyme genes (PEPCK and G6Pase) was reduced significantly by ferulic acid. It is concluded from the present study that FA treatment to type 2 diabetic rats improves insulin sensitivity and hepatic glycogenesis but inhibits gluconeogenesis and negative regulators of insulin signalling to maintain normal glucose homeostasis.

LC/MS-QToF Profiling, Anti-Diabetic and Anti-Adipogenic potential of Divya MadhuKalp: A Novel Herbo-mineral Formulation

“…Apocynin has the potential to improve insulin sensitivity 68 . Ferulic acid improved insulin sensitivity and hepatic glycogenesis but inhibits gluconeogenesis to maintain normal glucose homeostasis in type 2 diabetic rat 69 . Also, it has a potential to modulate adipogenesis via expressing of heme oxygenase-1 (HO-1) and suppressing C/EBPα and PPARγ, triglyceride–synthesizing enzymes, fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC) 70 .…”

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

“…Here, we have shown that SCCAM possess a similar capacity that NCRAE to enhance the glucose uptake on the L6 cells, indicating the value of the mixture of chicoric acid and chlorogenic acid on insulin sensitivity. The presence of Ferulic acid derivatives in NCRAE can be beneficial since trans-Ferulic acid has been reported to exert an antidiabetic effect by modulating insulin signaling pathway in the liver of type 2 diabetic rats (Narasimhan et al, 2015). The delayed improvement in OGTT can be due to the insulin sensitizing action of NCRAE by caffeoyltartaric acid derivatives and the stabilization of glycosuria may be related to the decrease in basal hyperglycemia.…”

Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) Attenuates Type 2 Diabetes and Its Associated Cardiomyopathy

“…The different compounds present within the SR have been reported to display hypoglycemic, anti-inflammatory and antioxidant effects which have been discussed hereunder. Ferulic acid manifests antidiabetic potential by modulating insulin-signaling molecules [59]. Caffeic acid possesses significant antidiabetic activity [60].…”