Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis

Mei, Zhengrong; Ye, Hong; Yang, Haiyi; Cai, Shihong; Hu, Yujun; Chen, Q. B.; Yuan, Zhongwen; Liu, Xixia

doi:10.1016/j.ejphar.2023.175642

Cited by 8 publications

(4 citation statements)

References 61 publications

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“…FA has been confirmed to improve Aβ plaque deposition, and spatial memory defects, and protects hippocampal neurons in AD model rats and mice. 14,53 A recent study confirmed that FA has a certain effect on cognitive impairment complicated by epilepsy, which may be related to inhibiting neuronal oxidative stress. 12 In addition, FA can improve the nerve injury in mice with cognitive impairment induced by high-fat diet, inhibit oxidative stress and cell apoptosis, which has positive significance for the prevention of age-related diseases.…”

Section: Discussionmentioning

confidence: 95%

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Ferulic Acid Activates SIRT1-Mediated Ferroptosis Signaling Pathway to Improve Cognition Dysfunction in Wilson’s Disease

Wang,

Shao,

Zhang

et al. 2023

NDT

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Background Wilson’s disease (WD), an autosomal recessive genetic disease, is characterized by copper metabolism disorder. WD patients may have a series of cognitive deficits in terms of neurological symptoms. Ferroptosis (FPT), a type of programmed cell death, is involved in the pathological progression of various cognitive disorders, and silent information regulator 1 (SIRT1) is considered to be a key factor in FPT. Ferulic acid (FA) is a traditional Chinese medicine monomer, with a remarkable effect in the clinical treatment of cognitive impairment-related disease. However, its intrinsic effect on FPT is still unclear. This study aims to investigate the protective effect of FA on cognitive impairment in animal and cell models of WD, and whether the pharmacological mechanism is related to the SIRT1-mediated FPT signaling pathway. Methods Copper-loaded WD rats and PC12 cells WD were used as models of cognitive dysfunction in vivo and in vitro, respectively. Morris Water Maze (MWM) was used to evaluate the spatial exploration and memory abilities of rats. HE staining was used to observe neuronal damage in the CA1 region of the rat hippocampus. Immunofluorescence (IF) was used to detect the expression of GPX4 protein. Transmission electron microscopy (TEM) was used to observe the ultrastructure of neurons. The levels of Fe2+, MDA, SOD, GSH, 4HNE, and ROS were detected. Western blot and qRT-PCR were used to detect the protein and mRNA levels of SIRT1, Nrf2, SCL7A11, and GPX4. Results In the WD copper-loaded model rats, MWM, TEM, and IF results showed that FA could promote the repair of learning and memory function, improve the morphological damage to hippocampal neurons, and maintain mitochondria integrity. In the PC12 cell experiment, the MTT method showed that FA increased the viability of copper-overloaded cell models. Western blot and qRT-PCR results confirmed that FA significantly increased the expression of proteins and mRNA in SIRT1, Nrf2, SCL7A11, and GPX4. In addition, FA reversed the expression of oxidative stress-related indicators, including MDA, SOD, GSH, 4HNE, and ROS. Conclusion FA alleviates hippocampal neuronal injury by activating SIRT1-mediated FPT, providing a valuable candidate for traditional Chinese medicine monomer for the clinical therapeutics of WD cognitive impairment.

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Section: Discussionmentioning

confidence: 95%

“…10 Currently, FA has been confirmed to have good efficacy in cognitive impairment caused by epilepsy, multiple sclerosis, ischemic hypoxia, type 2 diabetes, and high-fat diet. [11][12][13][14][15] Therefore, FA may become a potential drug for the treatment of WDCI, but further studies are lacking to confirm it.…”

Section: Introductionmentioning

confidence: 99%

Ferulic Acid Activates SIRT1-Mediated Ferroptosis Signaling Pathway to Improve Cognition Dysfunction in Wilson’s Disease

Wang,

Shao,

Zhang

et al. 2023

NDT

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“…Dihydromyricetin acted as an inhibitor of the JNK-inflammatory pathway, oxidative stress, and lipid peroxidation, and caused downregulation of ACSL4 and upregulation of GPX4 expression [ 83 ]. On the other side, ferulic acid and naringin are proven to activate the Nrf2/GPX4 axis which leads to the inhibition of ferroptosis and neuroprotection [ 77 , 84 ].…”

Section: Resultsmentioning

confidence: 99%

“…Collagenase-induced tendinopathy in SD rats [249] Ferulic acid Activates Nrf2/GPX4 pathway HT-22 cells High-fat-diet-induced cognitive impairment in C57BL/6 mice [84] Activates Nrf2/HO-1 pathway MLE-12 cells Acute lung injury model in BALB/c mice [134] Activates Nrf2 signaling pathway MIN6 cells / [250] Upregulates expression of GPX4 and AMPKα2 / Myocardial ischemia/reperfusion injury model in SD rats [251] Fisetin Downregulates expression of ACSL4 and COX2, and upregulates expression of GPX4 TCMK-1 cells Chronic kidney disease model in mice [252] Reduces levels of ROS and MDA, and increases the level of GSH, upregulates SIRT1, Nrf2, GPX4, HO-1, and FTH1…”

Section: Primary Tenocytes Isolated From Ratsmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease. Polyphenols, plant secondary metabolites known for many bioactivities, are being extensively researched in the context of their influence on ferroptosis which resulted in a great number of publications showing the need for a systematic review. In this review, an extensive literature search was performed. Databases (Scopus, Web of Science, PubMed, ScienceDirect, Springer) were searched in the time span from 2017 to November 2023, using the keyword “ferroptosis” alone and in combination with “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, and “chalcone”; after the selection of studies, we had 311 papers and 143 phenolic compounds. In total, 53 compounds showed the ability to induce ferroptosis, and 110 compounds were able to inhibit ferroptosis, and out of those compounds, 20 showed both abilities depending on the model system. The most researched compounds are shikonin, curcumin, quercetin, resveratrol, and baicalin. The most common modes of action are in the modulation of the Nrf2/GPX4 and Nrf2/HO-1 axis and the modulation of iron metabolism.

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Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala

Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis

Cited by 8 publications

References 61 publications

Ferulic Acid Activates SIRT1-Mediated Ferroptosis Signaling Pathway to Improve Cognition Dysfunction in Wilson’s Disease

Ferulic Acid Activates SIRT1-Mediated Ferroptosis Signaling Pathway to Improve Cognition Dysfunction in Wilson’s Disease

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala

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