Ferulic acid, a natural phenolic compound, as a potential inhibitor for collagen fibril formation and its propagation

Jayamani, Jayaraman; Ariram, Naisini; Madhan, Balaraman; Shanmugam, Ganesh

doi:10.1016/j.ijbiomac.2018.01.225

Cited by 18 publications

(5 citation statements)

References 51 publications

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“…Ferulic acid was studied with collagen as an inhibiting factor in collagen fibrillation during its accumulation [139]. A ferulic acid-chitosan conjugate was fabricated, and the formed complexes showed antioxidant activity [140].…”

Section: Phenolic Acids With Other Natural Polymersmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Section: Phenolic Acids With Other Natural Polymersmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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“…It was found that ferulic acid inhibits collagen self-association. Moreover, the enzymatic studies suggested that ferulic acid protects collagen from degradation 24 . Thereby, it can be confirmed that our results refer to the conclusions drawn by other scientists about the influence of phenolic acid on the enzymatic stability of collagen-based scaffolds.…”

Section: Discussionmentioning

confidence: 99%

The characterization of collagen-based scaffolds modified with phenolic acids for tissue engineering application

Kaczmarek-Szczepańska

Polkowska

Małek

et al. 2023

Sci Rep

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The aim of the experiment was to study the morphology of collagen-based scaffolds modified by caffeic acid, ferulic acid, and gallic acid, their swelling, and degradation rate, as well as the biological properties of scaffolds, such as antioxidant activity, hemo- and cytocompatibility, histological observation, and antibacterial properties. Scaffolds based on collagen with phenolic acid showed higher swelling rate and enzymatic stability compared to scaffolds based on pure collagen, and the radical scavenging activity was in the range 85–91%. All scaffolds were non-hemolytic and compatible with surrounding tissues. Collagen modified by ferulic acid showed potentially negative effects on hFOB cells as a significantly increased LDH release was found, but all of the studied materials had antimicrobial activity against Staphylococcus aureus and Escherichia coli. It may be assumed that phenolic acids, such as caffeic, ferulic, and gallic acid, are modifiers and provide novel biological properties of collagen-based scaffolds. This paper provides the summarization and comparison of the biological properties of scaffolds based on collagen modified with three different phenolic acids.

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“…Ferulic acid (FA), as an important ingredient in TCM, has therapeutic activity against a variety of diseases. The hepatoprotective effects of FA have been demonstrated in studies using CCl 4 to induce liver fibrosis (Jayamani et al, 2018;Ali et al, 2021;Li et al, 2021). Therefore, we proposed the combination of BMSCs and FA in the treatment of liver fibrosis and investigated the mechanisms underlying the antifibrotic effect in this study.…”

Section: Introductionmentioning

confidence: 97%

Ferulic Acid Combined With Bone Marrow Mesenchymal Stem Cells Attenuates the Activation of Hepatic Stellate Cells and Alleviates Liver Fibrosis

Zhang

Jiang

et al. 2022

Front. Pharmacol.

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Bone marrow mesenchymal stem cells (BMSCs) can effectively alleviate liver fibrosis, but the efficacy of cell therapy alone is insufficient. In recent years, a combination of traditional Chinese medicine (TCM) and cell therapy has been increasingly used to treat diseases in clinical trials. Ferulic acid (FA) is highly effective in treating liver fibrosis, and a combination of cells and drugs is being tested in clinical trials. Therefore, we combined BMSCs and Ferulic acid to treat CCl4-induced fibrosis and determine whether this combination was more effective than single treatment. We used BMSCs and FA to treat CCl4-induced fibrosis in rat models, observed their therapeutic effects, and investigated the specific mechanism of this combination therapy in liver fibrosis. We created a BMSC/hepatic stellate cell (HSC) coculture system and used FA to treat activated HSCs to verify the specific mechanism. Then, we used cytochalasin D and angiotensin II to investigate whether BMSCs and FA inactivate HSCs through cytoskeletal rearrangement. MiR-19b-3p was enriched in BMSCs and targeted TGF-β receptor II (TGF-βR2). We separately transfected miR-19b-3p into HSCs and BMSCs and detected hepatic stellate cell activation. We found that the expression of the profibrotic markers α-SMA and COL1-A1 was significantly decreased in the combination group of rats. α-SMA and COL1-A1 levels were also significantly decreased in the HSCs with the combination treatment. Cytoskeletal rearrangement of HSCs was inhibited in the combination group, and RhoA/ROCK pathway gene expression was decreased. Following angiotensin II treatment, COL1-A1 and α-SMA expression increased, while with cytochalasin D treatment, profibrotic gene expression decreased in HSCs. The expression of COL1-A1, α-SMA and RhoA/ROCK pathway genes was decreased in the activated HSCs treated with a miR-19b-3p mimic, indicating that miR-19b-3p inactivated HSCs by suppressing RhoA/ROCK signalling. In contrast, profibrotic gene expression was significantly decreased in the BMSCs treated with the miR-19b-3p mimic and FA or a miR-19b-3p inhibitor and FA compared with the BMSCs treated with the miR-19b-3p mimic alone. In conclusion, the combination therapy had better effects than FA or BMSCs alone. BMSC and FA treatment attenuated HSC activation and liver fibrosis by inhibiting cytoskeletal rearrangement and delivering miR-19b-3p to activated HSCs, inactivating RhoA/ROCK signalling. FA-based combination therapy showed better inhibitory effects on HSC activation.

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Ferulic acid, a natural phenolic compound, as a potential inhibitor for collagen fibril formation and its propagation

Cited by 18 publications

References 51 publications

Collagen-Based Materials Modified by Phenolic Acids—A Review

Collagen-Based Materials Modified by Phenolic Acids—A Review

The characterization of collagen-based scaffolds modified with phenolic acids for tissue engineering application

Ferulic Acid Combined With Bone Marrow Mesenchymal Stem Cells Attenuates the Activation of Hepatic Stellate Cells and Alleviates Liver Fibrosis

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