Fertility prognosis for infertile men: results of follow-up study of semen analysis in infertile men from two different populations evaluated by the Cox regression model

Bostofte, Erik; Bagger, Peter V.; Michael, Adel; Stakemann, G

doi:10.1016/s0015-0282(16)54012-6

Cited by 75 publications

(26 citation statements)

References 18 publications

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“…Sperm motility is one of the most important parameters utilized in the evaluation of spermatozoa quality obtained from semen samples in vitro (Mahadevan & Trounson, 1984) and in vivo (Bostofte et al, 1990;Barratt et al, 1993). Reduction in the percentage of mobile spermatozoa was probably one of the factors responsible for the reduction in fertility potential observed in animals exposed to DES.…”

Section: Discussionmentioning

confidence: 99%

Effects of altered epididymal sperm transit time on sperm quality

et al. 2008

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The epididymal sperm transit time seems to have an important role in the process of sperm maturation, and it seems that alterations to the transit can harm the process. The aim of the present work was to evaluate the influence of altered sperm transit time through the epididymis on sperm parameters and fertility of rats, as well as the role of testosterone in the alterations. Sprague-Dawley adult male rats were randomly assigned to four different groups and were treated for 12 days: (i) 10 microg/rat/day DES, to accelerate the transit; (ii) 6.25 mg/kg/day guanethidine sulphate, to delay the transit; (iii) same treatment as group 1, plus androgen supplementation; (iv) control animals received the vehicles. Guanethidine treatment delayed the sperm transit time through the epididymal cauda, provoking increased sperm reserves in this region. Animals exposed to DES showed an acceleration of sperm transit time in the epididymis, and consequently decreased sperm density in both epididymal regions, the caput-corpus and cauda, and diminished sperm motility. In both cases sperm production was not altered. Testosterone supplementation was able to restore the transit time to values close to normality, as they were higher than in the control rats. The same occurred in relation to sperm motility. Rats exposed to DES presented lower fertility after in utero artificial insemination using sperm collected from the proximal cauda epididymis. Therefore, it was concluded that the acceleration of rat sperm transit time appeared to harm normal sperm maturation, thus decreasing sperm quality and fertility capacity, in an androgen-dependent way.

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Section: Discussionmentioning

confidence: 99%

Effects of altered epididymal sperm transit time on sperm quality

et al. 2008

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“…For this purpose it was considered crucial to determine the exact shape of the relationship between semen characteristics and fertility. There have been various approaches to this subject (Bostofte et al, 1984(Bostofte et al, , 1990, but at present there is no model which can claim to have clarified the relationship between semen parameters and fertility in a satisfactory way. Thus a multivariate regression analysis using the continuous range of semen variables would not yield realistic results.…”

Section: Discussionmentioning

confidence: 99%

Semen analysis and fertility prognosis in andrological patients

Holland-Moritz

Krause

1992

Int J of Andrology

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Semen analyses of 529 men who consulted our department due to infertility problems, were related to the time period prior to conception, with factors adversely affecting the fertility of the female partner taken into consideration. The statistical method used was Cox's proportional-hazard model of regression. Untransformed, logarithmically transformed and dichotomized semen analysis variables were included in the calculations. The relationship between the following parameters and the probability of conception was examined: sperm count, sperm motility, progressive sperm motility, morphology and sperm motility remaining 24 h after ejaculation. All variables co-varied with the probability of conception; however, the exact type of relationship could not be determined by regression analyses. Cox's model assumes an exponential relationship. Our data suggest that this assumption is not suitable for fertility investigations. Using conventionally defined limiting values for normal and pathological semen quality, statistical analysis yielded significant differences in fertility between both categories for all of the variables considered; in the stepwise regression analysis, however, it could be shown that progressive motility and morphology alone were sufficient to discriminate between normal and pathological semen quality. The results are interpreted as indicating that, as a result of semen analysis, it is possible to predict the individual probability of conception if the exact shape of the relationship can be determined, which, up to now, has not been accomplished.

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“…The environment around spermatozoa, including seminal plasma, is thought to play an important role in sperm function (1), whereas low sperm concentration or reduced sperm motility is the primary cause of male infertility (2,3). Seminal plasma has been believed to provide an immunoprotective effect or immunotolerance to sperm in the female lower reproductive tract (4).…”

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confidence: 99%