Fertility prognosis for infertile couples

Bostofte, Erik; Bagger, Peter V.; Michael, Adel; Stakemann, G

doi:10.1016/s0015-0282(16)55623-4

Cited by 29 publications

(8 citation statements)

References 22 publications

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“…As reported in the literature (e.g. Bostofte et al ., 1990 ), in our data set older donors had semen parameters which were on average of lower quality and exhibited lower success rates. However, our data showed that this age effect was removed when sperm count and motility were taken into account in the analysis.…”

Section: Discussionsupporting

confidence: 67%

“…This was true for sperm counts and motility measured before freezing and for PTQI after thawing. Many authors have reported the same phenomena ( Schwartz et al ., 1979 ; Jouannet et al ., 1981 ; Bostofte et al ., 1990 , 1992; Marshburn et al ., 1991 ; Holland‐Moritz & Krause, 1992; Bartoov et al ., 1993 ). Several others have also reported the negative influence of the presence of a large proportion of morphologically abnormal spermatozoa ( Jouannet et al ., 1981 ; Bartoov et al ., 1993 ).…”

Section: Discussionmentioning

confidence: 99%

“…The factors predictive of successful insemination by donor spermatozoa have been identified in recent years. These are factors related to: (i) the recipient couple – the age of the woman ( CECOS Federation & Mayaux, 1982; CECOS Federation, 1993; Meyer et al ., 1996 ) and the nature of the male's infertility, azoospermia or oligo‐asthenospermia ( Emperaire et al ., 1981 ), (ii) factors to do with the insemination cycle, Insler score ( Insler et al ., 1972 ) on the day of insemination ( Schwartz et al ., 1979 ), proximity between day of insemination and presumed day of ovulation ( Schwartz et al ., 1979 ; Meyer et al ., 1996 ), and (iii) the characteristics of the spermatozoa inseminated, in particular the concentration of spermatozoa, their motility, the percentage of abnormal spermatozoa and the quality of the spermatozoa after thawing ( Jouannet et al ., 1981 ; Bostofte et al ., 1982 , 1990; Mayaux & Schwartz, 1985; Irvine & Aitken, 1986; Holland‐Moritz & Krause, 1992; Bartoov et al ., 1993 ; Clarke et al ., 1997 ).…”

Section: Introductionmentioning

confidence: 99%

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The mean of sperm parameters in semen donations from the same donor. An important prognostic factor in insemination

Écochard

Cottinet

Mathieu³

et al. 1999

Int J of Andrology

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We analysed 12,100 consecutive cycles of artificial insemination by donor spermatozoa in 1901 infertile couples. In our analysis, particular attention was given to finding an appropriate way of taking into account the respective effects of female and male factors on the pregnancy success rate and the level at which these factors act (cycle vs. woman and donation vs. donor). A total of 1213 pregnancies occurred. The pregnancy rate per cycle was lower as the age of the woman increased (p < 0.0001) and varied with the type of infertility: fecundity was higher (p = 0.03) in the case of azoospermia than of severe oligozoospermia. After taking into account these factors, significant unexplained variation in likelihood to conceive remained. A part of this heterogeneity was shown to be due to variation in fecundability between semen donors. In order to explain this heterogeneity between donors, compositional covariates were used, particularly the mean of results of the semen analysis performed for donations from the same donor. For each semen characteristic, the overall mean of the different donations of a donor was an important predictive factor of successful insemination: after taking into account all of the other factors, the odds ratios for an increase of 50 x 10(6)/mL spermatozoa, of a 20% increase in sperm motility and of a 2 point increase in the post-thaw quality index, were, respectively, 1.13, 1.37 and 1.56. After adjustment for these factors, the specific characteristics of each semen donation were no longer significantly predictive of successful insemination. This observation has a biological interpretation: sperm with low parameters but produced by a normally fertile man can have a satisfactory success rate.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The mean of sperm parameters in semen donations from the same donor. An important prognostic factor in insemination

Écochard

Cottinet

Mathieu³

et al. 1999

Int J of Andrology

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“…The value of motility determination in predicting male fertility was evaluated by several studies of conception rates following natural sexual intercourse (Bostofte et al, 1990(Bostofte et al, , 1993Culasso et al 1991;Barratt et al, 1993;Boyle et al, 1992), of the success of intrauterine insemination procedures (Brasch et al, 1994), and of the success of IVF or related procedures (Grunert et al, 1989;Liu et al, 1991;Nelson et al, 1993). In general, significant influences of sperm motility on the conception rates have been described in the abovementioned literature.…”

Section: Discussionmentioning

confidence: 99%

Computer-assisted semen analysis systems: comparison with routine evaluation and prognostic value in male fertility and assisted reproduction

Krause

1995

Human Reproduction

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Semen analysis was performed by employing a computer-assisted semen analysis (CASA) system (SM-CMA), in comparison with visual estimation by microscope. There was a significant relationship between the values obtained by both methods, but a large range of differences in individual values was observed. Results of semen analysis in 407 men complaining of reduced fertility were investigated for their relationship to fertility outcome. The parameters obtained by the CASA system were analysed in relation to time to conception, applying the Cox proportional hazards model of regression. In univariate regression analysis, all examined CASA parameters were shown to have a significant effect on cumulative hazard function. However, applying a multivariate step forward approach, only percentage of motile spermatozoa and log-transformed values of sperm count remained significant predictors of later fertility due to the close intercorrelations among the examined covariates. We concluded that the determination of elaborate motility characteristics as obtained by CASA systems is of limited value to optimizing the evaluation of male fertility status.

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“…However, little is known about the magnitude of spontaneous pregnancies in untreated couples after the first year of unprotected intercourse. Most studies which address this topic either excluded partnerships with certain abnormalities (Dumphy et al, 1990;Eimers et al, 1994), or unspecified treatments were performed during the observation period (Collins et al, 1984;Bostofte et al, 1993).…”

Section: Fertility Prognosis Of Untreated Infertile Couplesmentioning

confidence: 99%

Analysis of medical treatment of male infertility

Kamischke¹,

Nieschlag²

1999

Human Reproduction

121

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Since the first injection of a single spermatozoon into the cytoplasm of an oocyte (intracytoplasmic sperm injection, ICSI), this method has become the most successful means of treating male infertility. Even for patients long considered untreatable, a chance of paternity has become reality. Using not only ejaculated but also testicular spermatozoa, pregnancies have been achieved in the partners of patients who had never had a chance previously, including even cases with Klinefelter syndrome. However, despite the tremendous success of ICSI, most couples would prefer to conceive offspring naturally. Therefore we review the effectiveness of current conventional treatments for male infertility and analyse the chances of infertile couples to conceive spontaneously.

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Fertility prognosis for infertile couples

Cited by 29 publications

References 22 publications

The mean of sperm parameters in semen donations from the same donor. An important prognostic factor in insemination

The mean of sperm parameters in semen donations from the same donor. An important prognostic factor in insemination

Computer-assisted semen analysis systems: comparison with routine evaluation and prognostic value in male fertility and assisted reproduction

Analysis of medical treatment of male infertility

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