Fertility preservation in women with cervical, endometrial or ovarian cancers

Feichtinger, Michael; Rodriguez‐Wallberg, Kenny A.

doi:10.1186/s40661-016-0029-2

Cited by 41 publications

(46 citation statements)

References 150 publications

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“…Thus, fertility preservation has gained increasing attention, particularly given the increased number of effective options due to advances in reproductive medicine (Kim, Kim, Lee, & Woodruff, ). These options for preserving fertility include embryo cryopreservation, oocyte cryopreservation, transposition of the ovary and conservative gynaecological surgery (Feichtinger & Rodriguez‐Wallberg, ; Lambertini et al., ). Other procedures for fertility preservation are also being investigated and include cryopreservation and autotransplantation of ovarian tissue and gonadotropin‐releasing hormone (GnRH) agonists (Jeruss & Woodruff, ; Sonmezer & Oktay, ); moreover, GnRH agonists were recently recommended for preserving ovarian function and fertility in breast cancer patients (Lambertini et al., ; Paluch‐Shimon et al., ).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with frequency of discussion of or referral for counselling about fertility issues in female cancer patients

et al. 2016

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Current practices in counselling of female cancer patients with respect to fertility issues need considerable improvement, particularly given the general underuse of fertility preservation options and the negative impact that infertility can have on quality of life. We investigated the relationship between physicians' and physician-related factors and the frequency of physicians discussing fertility issues and referring to a reproductive specialist. We invited 1,832 physicians in the Netherlands who had treated at least five reproductive-age female cancer patients within the past year to complete a questionnaire. Of the 748 respondents, 406 met our inclusion criteria, and 280 participated. Analysis revealed that 79% of the participants usually or always discuss fertility issues. Specialty, confidence in knowledge regarding fertility issues and a lack of reproductive specialists in their region contributed independently to the variance in the frequency of discussing fertility issues. Moreover, 54% either regularly or always refer.Specialty and frequency of discussion contributed independently to the variance in referral. In conclusion, although high, frequency of discussion of fertility issues is not optimal, and referral seems limited. Patients would benefit from more knowledge among physicians regarding fertility issues and referral options, both in terms of informed choice, and more importantly, quality of life. K E Y W O R D Sadults, chemotherapy, communication, fertility preservation, physicians

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Section: Introductionmentioning

confidence: 99%

Factors associated with frequency of discussion of or referral for counselling about fertility issues in female cancer patients

et al. 2016

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“…Ovarian tissue can be easily obtained using laparoscopic techniques, without significant delay in gonadotoxic treatment [17]. Fertility preservation in women with cervical, endometrial and ovarian cancers is provided by both, fertility-sparing surgery and ART [18]. According to the literature, prevention of fertility in women with gynecological cancers is possible without disturbing the oncological safety [19].…”

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confidence: 99%

Assisted reproductive technology in reproductive medicine — possibilities and limitations

Szamatowicz

2016

Ginekol Pol

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Infertility has become an increasingly common health problem and has been estimated to affect approximately 10% of women in the reproductive age. Due to its high prevalence, it has been deemed a social disease by the World Health Organization (WHO). The causes of infertility are numerous and vary from person to person. As for treatment, the three main therapeutic strategies include pharmacological therapy, surgical therapy -mostly endoscopy, and assisted reproductive technology (ART). Recent decades have witnessed great progress in ART, resulting in successful treatment of the previously untreatable cases, particularly in the field of fertility preservation, preimplantation screening for aneuploidy, uterine transplantations and mitochondrial replacement techniques as prevention against a number of severe diseases. Regardless, ART treatment does not guarantee pregnancy and live birth. The success rate is much smaller as compared to the failure rate, it being among its most important limitations. Embryo implantation is an extremely complex process and represents the most critical step of the reproduction process in humans. Attempts to evaluate endometrial receptivity and strategies for its correction have been discussed. The search for new effective predictors of an individual prognosis remains a crucial challenge for the contemporary reproductive medicine.

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“…Surgery can be performed at every stage of pregnancy and in every anatomic region except the uterus and the ovaries in the first trimester [12].…”

Section: Surgical Treatmentmentioning

confidence: 99%

Overview Tumour Disease and Oncologic Therapy During Pregnancy

Findeklee

2018

Z Geburtshilfe Neonatol

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Newly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour prognosis is not negatively affected by pregnancy and gestation does not disclude oncologic therapy it is important to plan treatment immediately. Oncologic surgery preserving the uterus is not at all limited. Chemotherapy with anthracyclines, taxanes or platinum derivates is possible from the second trimenon on. Only radiotherapy should be avoided during pregnancy. Before initiating therapy, fertility preserving methods like cryopreservation of oocytes and/or ovarian tissue should be offered to the patient. Preterm birth is more common in women with a first diagnosis of cancer during pregnancy. Other negative effects on the child's future are not yet known. Treatment of pregnant cancer patients should be handled by experienced centres with a multi-professional team.

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Fertility preservation in women with cervical, endometrial or ovarian cancers

Cited by 41 publications

References 150 publications

Factors associated with frequency of discussion of or referral for counselling about fertility issues in female cancer patients

Factors associated with frequency of discussion of or referral for counselling about fertility issues in female cancer patients

Assisted reproductive technology in reproductive medicine — possibilities and limitations

Overview Tumour Disease and Oncologic Therapy During Pregnancy

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