Fertility Preservation in Women: Indications and Options for Therapy

Abstract

Fertility preservation (FP) is a vital issue for individuals in either reproductive or prepubescent stage of life when future fertility may be compromised. The objective of any FP intervention is to minimize or eliminate primary disease burden and to ensure maintaining or preserving reproductive health. Fertility potential can be affected by cancer therapy and numerous other factors, including advancing age, metabolic conditions, autoimmune diseases, specific surgical interventions, and sex affirmation procedures. A paradigm shift focusing on quality-of-life issues and long-term survivorship has emerged, especially because of advances in cancer diagnostics and treatment. Several FP techniques have been widely distributed, while others are still in the research stage. In addition, specific procedures and some potentially fertoprotective agents are being developed, aiming to minimize the hazards of gonadal damage caused by cancer therapy and decrease the need for more costly, invasive, and time-consuming FP methods. This review highlights the advances, indications, and options for FP, both experimental and well-established, in females of various age groups. An electronic search in PubMed, Embase, and Google Scholar databases was conducted, including retrospective studies, prospective clinical trials, meta-analyses, original reviews, and online abstracts published up to June 30, 2019. The search terms used included fertility preservation, oncofertility, embryo cryopreservation, oocyte cryopreservation, and ovarian tissue cryopreservation. The meeting proceedings of the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology were also hand searched.

Juvenile Dermatomyositis: New Clues to Diagnosis and Therapy

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Ovarian Tissue Culture for Fertility Preservation in Male Transgender Patients After Hormonal Treatment

“…The methods currently used to preserve the fertility of patients undergoing cytotoxic and hormonal treatments are the cryopreservation of embryos, oocytes and ovarian tissue. However, the available techniques have an indication limited to the patient's age and clinical status [4,5].…”

Preserving fertility in patients malignant

“…And most importantly, its desire to preserve future reproductive potential. (Waimey, 2015) [22] , (Hussein, 2020) [6,7] . It is highlighted that chemotherapy and radiotherapy have greatly improved the life expectancy of these patients in cancer patients who develop cancer at a young age.…”

“…This presented study focuses on the effects of cancer treatment on fertility and the various innovations offered medically, assisted reproduction, and surgery that patients can use to ~ 266 ~ achieve future pregnancy options and preserve fertility in a variety of medically foolproof and successful methods. (Hussein, RS, 2020) [6,7] . Whereas, given the great and increasing interest in the new fertility reserves that medicine provides to women.…”