Fertility preservation in the male pediatric population: factors influencing the decision of parents and children

Wyns, Christine; Collienne, Charlotte; Shenfield, Françoise; Robert, Annie; Laurent, Pascale; Roegiers, Luc; Brichard, Bénédicte

doi:10.1093/humrep/dev161

Cited by 92 publications

(72 citation statements)

References 49 publications

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“…Additionally, fertility preservation options vary by a child's age and sex, and remain experimental for young children . Families can also be overwhelmed by fertility‐related and cancer‐related information, or parents may choose not to share such information with their child . Due to the interplay of such factors, some survivors grow up knowing that they could be at‐risk for infertility, whereas others may be surprised to learn about such risk in survivorship …”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Families can also be overwhelmed by fertility-related and cancer-related information, or parents may choose not to share such information with their child. 11,12 Due to the interplay of such factors, some survivors grow up knowing that they could be at-risk for infertility, whereas others may be surprised to learn about such risk in survivorship. 11,[13][14][15][16] Such differences in risk awareness and/or fertility status may affect whether and how childhood cancer survivors engage in romantic relationships, but the available evidence is mostly anecdotal.…”

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confidence: 99%

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The perceived impact of infertility on romantic relationships and singlehood among adult survivors of childhood cancer

et al. 2019

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Objective To examine whether adult survivors of childhood cancer perceive a direct impact of potential/confirmed infertility on their romantic relationships/singlehood. Methods Open‐ended qualitative phone interviews were conducted with 57 adult survivors of childhood cancer and analyzed through thematic content analysis until saturation was reached (N = 30). Results Interviews revealed three major themes: (1) impact on survivors, (2) impact on partners/romantic relationships, and (3) alternative routes to parenthood. An overarching theme related to (4) timing also emerged. In describing the impact on themselves, survivors shared subthemes of (1.1) becoming aware of infertility as potential late effect of childhood cancer treatment and (1.2) their emotional reactions (ie, worries/concerns, distress, guilt, no emotional reaction). The impact on partners/romantic relationships also included subthemes: (2.1) partner communication, (2.2) partner reactions, and (2.3) the journey of active family planning. Conclusions The perceived impact of potential/confirmed infertility on romantic relationships of adult survivors of childhood cancer varied across individuals and time. Its presence or absence depends on life circumstances (eg, marital status, life goals), and if present, negative effects were typically resolved over time by having a pregnancy. Other survivors found joy and comfort in step‐children, considering adoption, or embracing a life without children. While more research is needed, findings indicate that discussions about infertility and fertility testing should be tailored to individual survivors and their needs, which may change over time. Timely referrals to reproductive specialists or adoption agencies are recommended for those who want children and have difficulties conceiving.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

The perceived impact of infertility on romantic relationships and singlehood among adult survivors of childhood cancer

et al. 2019

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“…The increasing efficacy of these treatments, with more than 80% of patients surviving their disease [1,2], places higher priority on fertility preservation techniques, as this becomes a major quality-of-life issue for patients [3,4]. Since no spermatozoa are produced before puberty, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells is the only option for fertility preservation in prepubertal patients, with a view to future autotransplantation or in vitro maturation [5,6].…”

Section: Introductionmentioning

confidence: 99%

Transplantation of testicular tissue in alginate hydrogel loaded with VEGF nanoparticles improves spermatogonial recovery

Poels

Abou-Ghannam

Decamps

et al. 2016

Journal of Controlled Release

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“…64,66 Paradoxically, even those TYAs who do not prioritize future parenthood value information regardless of their decision to proceed with FP or not. 14,21,63,67 This suggests that further explanatory communication with parents about the 486 NORTON AND WRIGHT value of a FP discussion, as advocated in this study, is indeed required to facilitate the TYAs' reproductive priorities to be voiced. Potential difficulties should be skillfully anticipated and managed by nurses.…”

Section: Discussionmentioning

confidence: 82%

Barriers and Facilitators to Fertility-Related Discussions with Teenagers and Young Adults with Cancer: Nurses' Experiences

Norton

Wright

2020

Journal of Adolescent and Young Adult Oncology

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Introduction: Improvements in cancer survival rates for teenagers and young adults (TYAs) have resulted in quality-of-life issues into survivorship becoming increasingly important. However, infertility is a potential late side effect of cancer treatment, which can negatively impact on quality of life. Advances in assisted reproductive technologies have resulted in increasingly effective fertility preservation (FP) options. Purpose: This study aimed to explore nurses' experiences of undertaking fertility-related discussions with TYAs with cancer aged 13-24 years. Methods: An interpretive phenomenological analysis (IPA) approach was used. Eleven purposively selected nurses working on a specialist TYA cancer unit participated in semistructured interviews. Data were analyzed using IPA. Results: Parents/family were experienced as self-appointed informal gatekeepers who were perceived to hold the power to control nurses' access to communicate with young people about fertility issues. Nurses adopted a supportive role, which was enhanced by the positive nature of their relationship with the TYA. Uncertainty was expressed over whether the TYA had been fully informed of their infertility risk and potential FP options. Conclusions: Nurses should manage parental involvement sensitively if TYAs are to make informed decisions regarding their future reproductive health. There is a need for clear role delineation in fertility discussions to ensure that TYAs are provided with the opportunity to discuss infertility risk and be referred to a specialist before initiating cancer treatment. Nurses should cultivate the primacy of the nurse-TYA relationship to improve fertility care. Further research into the factors that TYAs may consider beneficial within the nursepatient relationship is required.

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Fertility preservation in the male pediatric population: factors influencing the decision of parents and children

Abstract: NCT02411214.

Cited by 92 publications

References 49 publications

The perceived impact of infertility on romantic relationships and singlehood among adult survivors of childhood cancer

The perceived impact of infertility on romantic relationships and singlehood among adult survivors of childhood cancer

Transplantation of testicular tissue in alginate hydrogel loaded with VEGF nanoparticles improves spermatogonial recovery

Barriers and Facilitators to Fertility-Related Discussions with Teenagers and Young Adults with Cancer: Nurses' Experiences

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