Fertility Predictors in Intrauterine Insemination (IUI)

Abstract

(1) Background: Intrauterine insemination (IUI) is considered a first-line procedure for infertile or hypo-fertile couples among assisted reproductive techniques. In our retrospective study, we identified variables associated with a successful IUI and the probability of obtaining a pregnancy. This is useful to identify couples with a good chance of obtaining a pregnancy through an IUI procedure (2) Methods: The study was conducted at a university-level fertility clinic in Oradea, Romania. Patients eligible to participate in the study were infertile couples who underwent IUI treatment in the interval between January 2015 and October 2020. (3) Results: In our study, we found that duration of infertility, couple age, endometrium thickness, sperm concentration, and motility are important factors in determining the outcome of IUI. Several demographics were measured for each couple including maternal and paternal age, the type and duration of infertility, the number of procedures, the type of ovarian stimulation, number of follicles, endometrial thickness, the type and day of ovulation induction, associated pathology, tubal patency, and pre/post washes sperm count and progressive sperm motility. (4) Conclusions: Fertility prediction studies are necessary, and an individualized prognostic score should be applied for each couple for tailoring their expectations and better counseling.

Low Estradiol Level and Endometrial Thickness on the Day of Endometrial Transformation Influence Clinical Pregnancy After Intrauterine Insemination

“…29 Studies have shown that endometrial thickness was positively correlated with pregnancy rate after IUI. 16,[30][31][32] Li et al found that the increase of endometrial thickness can significantly improve the clinical pregnancy rate after IUI. 33 In addition, study has shown that endometrial thickness has no predictive value for IUI outcomes.…”

“…30,[41][42][43] Huniadi et al found that sperm concentration and motility are important factors in determining IUI outcome. 32 Most studies agree that high sperm motility is the key to pregnancy after IUI, but different studies have shown different thresholds for total motile sperm count. Most data agree that IUI is appropriate for men with a total motile sperm count of more than 5 million and a post-wash sperm count of more than 1 million.…”

Perioperative Analgesia and Patients’ Satisfaction in Spinal Anesthesia for Cesarean Section: Fentanyl Versus Morphine

“…In a recent systematic review completed with a Bayesian network meta-analysis conducted by Hiroyuki Seki and colleagues [12], clinically relevant opioid-related adverse effects were investigated, but the results concerning the vomiting were inconsistent. They concluded that, while lipophilic opioids might decrease intraoperative nausea and/or vomiting associated with uterine exteriorization, hydrophilic opioids might exacerbate these side effects [12,36].…”

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

“…Genetic markers not only have the potential to aid in the diagnosis of UI, but they could also play a crucial role in personalized treatment. Currently, the standard treatment for UI is assisted reproductive technology (ART), which includes procedures such as in vitro fertilization (IVF) and intrauterine insemination (IUI) [130]. These treatments can be expensive, time-consuming, and emotionally taxing.…”