Fertility of Patients with Solitary Testes

Woodhead, David M.; Pohl, Donald R.; Johnson, Douglas E.

doi:10.1016/s0022-5347(17)60351-3

Cited by 48 publications

(10 citation statements)

References 6 publications

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“…Approximately 25-30% of patients with a history of unilateral cryptorchidism and up to 50% of patients with a history of bilateral cryptorchidism were found to have oligospermia [35][36][37]. Defective spermatogenesis has been documented to occur in the contralateral testis in men with unilateral cryptorchidism, which suggests a genetic defect inherent to both testicular descent and spermatogenesis [19,38]. However, it is still unclear as to whether the genetic factor(s) that controls testicular descent also directs spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

Do microdeletions in the AZF region of the Y chromosome accompany cryptorchidism in Turkish children?

et al. 2007

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Studies on Y chromosome microdeletions are important due to a potential for the transmission of genetic abnormalities to offspring. Assisted reproduction techniques may cause the transmission of genetic abnormalities to offspring because the physiological fertilisation mechanism is bypassed. It was found that there was probably no aetiologic correlation between microdeletions in gene loci on the AZF-a, AZF-b and AZF-c regions of the Y chromosome and cryptorchidism.

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Section: Discussionmentioning

confidence: 99%

Do microdeletions in the AZF region of the Y chromosome accompany cryptorchidism in Turkish children?

et al. 2007

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“…Spermatogenesis in unilateral cryptorchids is often impaired. Woodhead, Pohl and Johnson (1973) found 17 out of 47 men with unilateral cryptorchidism and palpably normal solitary scrota1 testes to be oligozoospermic. Lipshultz et al (1976) showed that men operated on for unilaterally undescended testis at the age of 4 to 12 years had abnormal spermatogenesis when they were 21 to 35 years old, and their FSH-response to gonadotropin releasing hormone was significantly greater than in controls.…”

Section: Discussionmentioning

confidence: 99%

The Testes After Torsion

Krarup

1978

British Journal of Urology

248

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In torsion of the testis a large proportion of testes saved by surgery develop secondary atrophy. External manual reduction may be used as a first treatment, but surgical fixation is mandatory before the patient leaves the hospital. Prophylactic fixation of the contralateral testis should always be performed as 30% of the patients will otherwise develop symptoms. The preventive operation causes no discomfort to the patient and no harm to the testis. The fertility of the torsion patients is reduced. Patients treated for unilateral testicular torsion seem to have bilateral testicular abnormality resulting in decreased spermatogenesis.

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“…Thus testes prone to torsion seem to have a subtle pre-existing abnormality of spermatogenesis. The situation is analogous to the bilateral impairment of sperm production that explains low sperm counts in unilateral cryptorchids (Woodhead et al, 1973). Since cryptorchidism itself predisposes to torsion (Anderson and Williamson, 1988), congenital anomalies of the testis appear to be multiple.…”

Section: A Testis That Has Undergone Torsion Mightmentioning

confidence: 99%