Fertility in Males With Sickle Cell Disease

Osegbe, D N; Akinyanju, O. O.; Amaku, E O

doi:10.1016/s0140-6736(81)90525-0

Cited by 71 publications

(45 citation statements)

References 7 publications

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“…lower percentage of normal morphology than healthy controls [126], all features that contribute to infertility. In another comprehensive evaluation of semen in 34 men with SCD, Berthaut et al evaluated semen quality based on WHO criteria for fertility based on normal values for four semen parameters including at least 20 million/ml sperm concentration, 50% minimum forward motility, greater than 60% sperm viability, and greater than 30% morphologically normal spermatozoa.…”

Section: Reproductive Health In Adults With Scdmentioning

confidence: 81%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

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Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimistic that the next 40 years will be focused on meeting current challenges in SCD by addressing chronic complications of SCD to reduce mortality and improve quality of life in a growing population of adults with SCD in high-income countries, while simultaneously decreasing the disparity of medical care between high and low-income countries.

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Section: Reproductive Health In Adults With Scdmentioning

confidence: 81%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

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“…15,16 Although some reports suggest that delayed puberty in males contributes to sperm abnormalities in those ,25 years of age, these abnormalities improve in older men as testosterone levels increase.…”

Section: Sperm Abnormalitiesmentioning

confidence: 99%

Reproductive issues in sickle cell disease

Smith‐Whitley

2014

Blood

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As medical advances improve survival, reduce disease-related morbidity, and improve quality of life, reproductive issues will take higher priority in the sickle cell disease (SCD) community. A wide variety of topics are addressed in this chapter, including fertility, gonadal failure, erectile dysfunction, and menstrual issues in SCD. Etiologies of impaired male fertility are multifactorial and include hypogonadism, erectile dysfunction, sperm abnormalities, and complications of medical therapies. Much less is known about the prevalence and etiology of infertility in women with SCD. Other reproductive issues in women included in this review are pain and the menstrual cycle, contraception, and preconception counseling. Finally, long-term therapies for SCD and their impact on fertility are presented.Transfusional iron overload and gonadal failure are addressed, followed by options for fertility preservation after stem cell transplantation. Focus is placed on hydroxyurea therapy given its benefits and increasing use in SCD. The impact of this agent on spermatogenesis, azoospermia, and the developing fetus is discussed. (Blood. 2014;124(24):3538-3543) IntroductionReproductive issues in women and men with sickle cell disease (SCD) include a wide array of complications that are relatively common; however, data from well-designed, large clinical studies are limited. Many studies are quite old, but remain relevant because they describe clinical complications and problems that persist in the SCD population today despite advances in medical therapy. Not unexpectedly, some of the reproductive issues in SCD arise due to chronic medical therapies that are used increasingly to prevent or manage SCD-related morbidity. Fertility in menInfertility in men with SCD has been studied more frequently than infertility in women and appears to have multiple causes, including hypogonadism, sperm abnormalities, and erectile dysfunction (ED) due to priapism. Although a delay in sexual maturation of 1.5-2 years, on average, occurs in adolescents and young adults with SCD, 1,2 most go on to have normal sexual maturation. However, up to 24% of men with SCD may develop hypogonadism, a clinical syndrome associated with poor testosterone production, infertility, ED, and poor libido.3 Clinical characteristics include sparse facial, pubic, and axillary hair and small testicular size. Clinical laboratory findings are low testosterone levels with variable follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. 4 Possible underlying pathophysiologic mechanisms of hypogonadism include disruptions in the hypothalamic-pituitary-gonadal axis leading to primary testicular failure. However, studies are inconsistent as to whether primary testicular failure 5,6 or secondary hypothalamic-pituitary dysfunction 3,4,[7][8][9] is the cause. A recent report found low serum testosterone levels in 8 of 34 men with SCD and all 8 had low FSH and LH levels, suggesting a central mechanism.3 Multiple theories as to why these abnormalities develop in ma...

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“…Although in this study, any intention of paternity has not been directly investigated, no young adult with sickle-cell anaemia in this sample, with normal testosterone levels in the group, has experienced paternity, thereby highlighting the need to investigate aspects related to male fertility. Men with sickle-cell anaemia may have fertility issues related to quantitative and/or qualitative changes in semen, or sexual problems, such as impotence, priapism and frequent episodes of premature ejaculation as previously reported 27 . The literature reports that infertility seems to be a bigger problem among men than among women with sickle-cell anaemia 14 .…”

Section: Discussionmentioning

confidence: 71%

Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Gomes

Melo

et al. 2017

J. Hum. Growth Dev.

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Suggested citation: Gomes ICP, Melo HI, Melo SIA, Menezes NV, Dantas TVP, Cipolotti R. Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years. J Hum Growth Dev. 2017; 7(1): 91-98 AbstractIntroduction: Hereditary haemoglobinopathies are the most common group of monogenic hereditary diseases in the world. Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands.

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Fertility in Males With Sickle Cell Disease

Cited by 71 publications

References 7 publications

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Reproductive issues in sickle cell disease

Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

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