Fertility control

Yuehchukene, a Novel Anti-implantation Indole Alkaloid fromMurraya paniculata

“…More interesting is the synthesis of structural analogues that can fully exploit the pharmacoligical potentials in the natural molecular design of yuehchukene. A recent review of the new development of fertility control agents concerned only established reproductive hormones (14). There is virtually a total absence of any lead or effort to develop postcoital interceptives.…”

Effects of gossypol on the motility of mammalian sperm

“…Contraceptive agents may interfere with the continual process of spermatogonia production by the seminiferous germinal epithelium or with the development and maturation of epididymal sperm (Hinton, 1980). In the search for a reversible male contraceptive, the focus of many investigators has been the suppression of sperm production (Harper, 1982;Jackson and Schnieden, 1982;Aitken, 1983;Bernstein, 1984;Diczfalusy, 1985). Attempts a t pharmacological male-fertility control in laboratory animals and humans have mainly made use of hormones (Swerdloff and Heber, 1983;Lohiya and Sharma, 1985;Rousseau et al, 1985;Wong and Lee, 1985).…”