Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review

Corkum, Kristine S.; Rhee, Daniel S.; Wafford, Q. Eileen; Demeestere, Isabelle; Dasgupta, Roshni; Baertschiger, Reto M.; Malek, Marcus M.; Aldrink, Jennifer H.; Heaton, Todd E.; Weil, Brent R.; Madonna, Mary Beth; Lautz, Timothy B.

doi:10.1016/j.jpedsurg.2018.12.021

Cited by 61 publications

(36 citation statements)

References 92 publications

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“…The common forms of childhood cancers that may require aggressive gonadotoxic anticancer therapy and hence necessitate prior fertility preservation measures are leukemia, central nervous system cancers, lymphoma, and sarcomas. Unique medical challenges in oncofertility programs for childhood cancer exist and include the following: (1) freezing of gonadal tissues is the only suitable cryopreservation option before puberty, and (2) autotransplantation of frozen gonadal tissue may carry the risk of reintroducing malignant cells, especially in leukemia which is the most common childhood cancer [36][37][38][39][40][41][42].…”

Section: Installing Oncofertility Programs For Childhood Cancer In Opmentioning

confidence: 99%

Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion

2021

J Assist Reprod Genet

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Purpose The main objective of Repro-Can-OPEN Study Part 2 is to learn more about oncofertility practices in optimum resource settings to provide a roadmap to establish oncofertility best practice models. Methods As an extrapolation for oncofertility best practice models in optimum resource settings, we surveyed 25 leading and wellresourced oncofertility centers and institutions from the USA, Europe, Australia, and Japan. The survey included questions on the availability and degree of utilization of fertility preservation options in case of childhood cancer, breast cancer, and blood cancer. Results All surveyed centers responded to all questions. Responses and their calculated oncofertility scores showed three major characteristics of oncofertility practice in optimum resource settings: (1) strong utilization of sperm freezing, egg freezing, embryo freezing, ovarian tissue freezing, gonadal shielding, and fractionation of chemo-and radiotherapy; (2) promising utilization of GnRH analogs, oophoropexy, testicular tissue freezing, and oocyte in vitro maturation (IVM); and (3) rare utilization of neoadjuvant cytoprotective pharmacotherapy, artificial ovary, in vitro spermatogenesis, and stem cell reproductive technology as they are still in preclinical or early clinical research settings. Proper technical and ethical concerns should be considered when offering advanced and experimental oncofertility options to patients. Conclusions Our Repro-Can-OPEN Study Part 2 proposed installing specific oncofertility programs for common cancers in optimum resource settings as an extrapolation for best practice models. This will provide efficient oncofertility edification and modeling to oncofertility teams and related healthcare providers around the globe and help them offer the best care possible to their patients.

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Section: Installing Oncofertility Programs For Childhood Cancer In Opmentioning

confidence: 99%

Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion

2021

J Assist Reprod Genet

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“…Another review reported on 1019 patients undergoing OTCP with ages ranging from 0.4 to 20.4 years, with 298 aged younger than 13 years. Eighteen patients underwent auto-transplantation of thawed ovarian cortical tissue that was cryopreserved before the age of 21 years, resulting in 10 live births (Corkum et al, 2019). An update paper on worldwide OTCP activity and on the Danish cohort reported a total of 93 children born, and 51% pregnancies were achieved by natural conception.…”

Section: Otcp For Girls With Tsmentioning

confidence: 99%

Time to consider ovarian tissue cryopreservation for girls with Turner’s syndrome: an opinion paper

Jeve

Gelbaya

Fatum

2019

Human Reproduction Open

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Turner’s syndrome (TS) is the most common sex chromosome abnormality in women. In addition to short stature and gonadal dysgenesis, it is associated with cardiac and renal anomalies. Due to rapid follicular atresia, the majority of women with TS suffer from primary ovarian insufficiency around puberty. Thus far, donor oocyte conception has been the key fertility option for these women. With advancing technology, ovarian tissue cryopreservation (OTCP) has emerged as a clinically justifiable option especially for pre-pubertal girls with cancer. Recently published results following the use of cryopreserved ovarian tissue are reassuring. It would be prudent to consider the extension of these technological and scientific advances to other conditions, such as TS, where accelerated follicular atresia is suspected. It is possible to obtain competent oocytes from cryopreserved ovaries of girls with TS provided the ovaries were preserved before ovarian failure. However, it is a complex decision whether and when to offer OTCP as a fertility preservation (FP) option for girls with TS. The rate of decline in fertility is variable in girls with TS and can be more complex in cases with mosaicism. On the other hand, OTCP has shown some promising results in patients with cancer, which can potentially be replicated in TS and other benign indications of patients at risk of premature ovarian failure. There are proven psychological and clinical benefits of FP. Thus, an argument could be made for offering OTCP to these patients to endow these girls with the option of having biological fertility using this innovative technology. Ethical, clinical and psychological dilemmas should be considered, discussed and addressed before considering such a novel approach. We believe that the time has come to start this discussion and open this avenue of FP for girls with TS.

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“…Following the data collection of about 2000 specialized studies, the following results were found: most patients underwent ovarian tissue cryopreservation, followed by oocyte sampling, ovarian transposition and ovarian tissue self-transplantation. However, statistical data on the evolution of these patients are limited, so the conclusions could not be drawn [12].…”

Section: B Ovarian or Embryonic Preservation Without Ovarian Stimulamentioning

confidence: 99%

Preserving Fertility in Ovarian Cancer

Dinca¹,

Dinca²,

Bîrlă³

et al. 2019

Rev. Chim.

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In the last decades, by improving the oncological treatment, the life expectancy of the adolescent patients with ovarian cancer has been increased and more than that they have succeeded by a real chance of obtaining a future pregnancy. Thus, the problem of preserving fertility becomes paramount both for patients who have suffered from an oncological disease and for those up to the age of 40 who have fertility problems.

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Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review

Abstract: Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review.

Cited by 61 publications

References 92 publications

Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion

Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion

Time to consider ovarian tissue cryopreservation for girls with Turner’s syndrome: an opinion paper

Preserving Fertility in Ovarian Cancer

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