Fertility and blood progesterone levels following LHRH-induced superovulation in FSH-treated anestrous goats

Akinlosotu, B.A.; Wilder, Cailin

doi:10.1016/0093-691x(93)90357-b

Cited by 19 publications

(4 citation statements)

References 25 publications

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“…Similar consideration should be taken when using hormones to induce ovulation (i.e., GnRH and LH). In previous studies, the use of GnRH after sponge removal concentrated the time to ovulation and increased the ovulation rate in ewes subjected to SOV (AKINLOSOTU & WILDER, 1993). However, in the current study, the use of LH was insufficient to concentrate the time to ovulation of the follicles from the same ewe and among the ewes, but it also seems to anticipate ovulation.…”

Section: Veigacontrasting

confidence: 45%

Does supplemental LH changes rate and time to ovulation and embryo yield in Santa Ines ewes treated for superovulation with FSH plus eCG?

et al. 2012

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Section: Veigacontrasting

confidence: 45%

Does supplemental LH changes rate and time to ovulation and embryo yield in Santa Ines ewes treated for superovulation with FSH plus eCG?

et al. 2012

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“…However, additional evidence has demonstrated that a high concentration of progesterone might impair uterine receptivity and implantation (Liang et al, 2018) and that an aberrant progesterone/estrogen ratio is also harmful to early pregnancy (Maclin et al, 1990), indicating that the concentration of progesterone should be in a suitable range to support implantation. Here, we discovered that a routine superovulation operation increases progesterone and the progesterone/estrogen ratio in mice, which was consistent with previous studies (Akinlosotu and Wilder, 1993). Considering the neutralization effects between E2 and P4, the adjustment of the serum P4/E2 ratio might be helpful in clinical treatments under a similar situation.…”

Section: Discussionsupporting

confidence: 91%

Three-Dimensional Visualization of Mouse Endometrial Remodeling After Superovulation

Zhang

Guo

et al. 2022

Front. Cell Dev. Biol.

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Uterine status determines pregnancy success. Although it is well known that superovulation operations can disrupt uterine function, our understanding of the morphological changes in the uterine endometrium at the three-dimensional (3D) level is limited. Here, combining the tissue clearing with 3D deep imaging, we reveal an increase in epithelial density and angiogenesis after ovarian stimulation, which is accompanied by a circulating surge in P4 levels. Using an ovariectomized mouse model, we further detected the separate regulatory effects of P4 and E2 on the uterine endometrium, with P4 promoting endothelial cell growth and E2 inducing epithelial proliferation. Additionally, we observed that the effects of E2 can be partially neutralized by P4, and vice versa. By analyzing the 3D uterine imaging, we discovered an interesting phenomenon in which the growing blood vessels closely surround the remodeling uterine epithelium, indicating a close relationship between angiogenesis and epithelial growth. These findings provide new insight into the uterine epithelial changes and angiogenesis at the 3D level, and explain a potential reason for endometrial changes due to the low implantation rate in patients undergoing clinic super-ovulation.

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“…Successful fertilization of donor females depends on synchronization of ovulation and on the method used to inseminate the females. A reduction in the range in ovulation timing (that is, the time elapsed between the first and the last ovulation) and an increase in ovulation rate was obtained using GnRH injections at a fixed time after the end of the progestagen treatment (Akinlosotu and Wilder, 1993;Krisher et al, 1994). Another alternative is the use of a GnRH antagonist, 12 h after sponge removal, followed by an intravenous injection of 3 mg pLH 24 h later, which mimics the preovulatory LH surge and allows the artificial insemination of the females only once, 16 h after LH injection (Baril et al, 1996a).…”

Section: Embryo Production Collection Freezing and Transfermentioning

confidence: 99%

Implications of recent advances in reproductive physiology for reproductive management of goats

Chemineau

Baril²,

Leboeuf³

et al. 2019

Proc

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The control of reproduction in goats is interesting for technical reasons (synchronization of kiddings, adjustment to forage availability or to economy), and for genetic reasons (identification and dissemination of improved genotypes). The use of short-light rhythms leads to markedly increased production of semen per buck and prevents occurrence of a 'resting' season. Recent identification of a bulbourethral lipase in goat spermatozoa opens new perspectives in sperm preservation. Light plus 'short day' treatments also allow induction of out-of-season oestrous cycles and ovulations leading to enhanced fertility. Repeated use of eCG provokes the production of antibodies, delays the timing of ovulation and causes a reduction in fertility after fixed-time artificial insemination. All steps of embryo production, freezing and transfer are now controlled and allow the attainment of satisfactory numbers of kids born per donor female, which are compatible with the development of the technique for exchanging genotypes between countries. In vitro production of embryos allows high development rates to be achieved after in vitro maturation and fertilization of oocytes, and will ensure the production of synchronous populations of one-cell zygotes at the stage required by new biotechnologies.

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Fertility and blood progesterone levels following LHRH-induced superovulation in FSH-treated anestrous goats

Cited by 19 publications

References 25 publications

Does supplemental LH changes rate and time to ovulation and embryo yield in Santa Ines ewes treated for superovulation with FSH plus eCG?

Does supplemental LH changes rate and time to ovulation and embryo yield in Santa Ines ewes treated for superovulation with FSH plus eCG?

Three-Dimensional Visualization of Mouse Endometrial Remodeling After Superovulation

Implications of recent advances in reproductive physiology for reproductive management of goats

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